Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 161-180 of 472
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Tumor acidosis in malignant progression and therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-04-06)Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies ... -
Studies on caspase signaling in microglia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-03-18)The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous ... -
HLA-A*02 and its prognostic traits in cancer : an immunological biomarker as a tool towards individualised cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-01-15)This thesis is based on the findings that HLA-A*02, a common allele in the Swedish population, has a decreasing frequency in the European continent in relation to geographic latitude. Furthermore, mortality of ovarian ... -
Genetic and molecular background of pheochromocytoma and paraganglioma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-15)Pheochromocytomas (PCC) and abdominal paragangliomas (PGL), collectively denoted PPGL, are neuroendocrine tumors (NET) with a highly diverse genetic and molecular etiology, arisen in the adrenal medulla and abdominal ... -
Hormonal consequences, replacement therapy, and lost workdays after cervical cancer treatment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-11-20)Background: Uterine cervical cancer affects women of all ages and has a generally favorable prognosis. Many survivors live long with the consequences of the disease and its treatment, and therefore it is important to ... -
Hunting the end of the rainbow : prognostic biomarkers and human papillomavirus in tonsillar and base of tongue cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-11-20)Aim: The aim of this thesis was to hunt for additional prognostic biomarkers in HPV positive TSCC and BOTSCC to identify patients that could if they wished, be enrolled in clinical trials for de-escalation of treatment. ... -
The p53-induced Wig-1 protein : identification of mRNA targets and role as a survival factor in development and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-11-09)The tumor suppressor p53 is activated in response to a variety of stress conditions. Upon activation, p53 can trigger apoptosis or cell cycle arrest, or regulate metabolism and other cellular processes by transactivation ... -
Cancer risks and prognosis in familial melanoma kindreds
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-11-04)Malignant melanoma of the skin is one of the most rapidly increasing cancers in many western countries, including Sweden. This incidence rise is mainly attributed to sun-seeking habits with increased intermittent UVR ... -
Graft viability and transfusion related complications in patients undergoing stem cell transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-10-28)Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment strategy for patients with hematopoietic malignancies and inborn errors of metabolism or immunodeficiencies. A successful clinical outcome depends ... -
Characterisation of molecular alterations in diffuse large b-cell lymphoma with respect to transformation, progression and prognostic markers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-10-23)Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma type, and comprises nearly 500 newly diagnosed cases in Sweden every year. DLBCL is a group of aggressive lymphomas that are extremely heterogeneous and ... -
The role of HLA-A*02 and biomarkers in solid malignant tumours
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-10-19)HLA-A*02 genotype generates significantly worse outcome in patients with metastatic serous ovarian cancer and malignant melanoma. HLA-A*02 is common in the Swedish population (about 60 %), but has decreasing frequency in ... -
Postmortem analyses of vitreous fluid
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-10-16)The identification of various various medical conditions postmortem is often difficult. Results from analysis of postmortem blood and urine samples are not as appropriate as in living subjects, due to bacterial contamination ... -
Methodological approaches towards personalised cancer medicine
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-10-02)Despite advances in diagnostics and treatments, many cancer patients have poor survival rates. Tumours develop drug resistance followed by metastasis, and survivors suffer from treatment side-effects. Omics techniques, ... -
Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-09-22)Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general ... -
Telomerase activation and its clinical implications in human thyroid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-09-22)Telomerase is a ribonucleoprotein enzyme. The catalytic and rate-limiting component of telomerase is referred to as telomerase reverse transcriptase (TERT) that plays an important role in telomere maintenance, cell ... -
Identification, validation and clinical application of a three-gene signature for accurate prognosis prediction and treatment selection of newly diagnosed prostate cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-09-16)This thesis presents a complete, comprehensive and stepwise approach of translational molecular research. Starting from whole-genome bioinformatics analyses based on the embryonic stem (ES) cell hypothesis, a three-gene ... -
Self performed treatment in female cancer survivors with secondary lymphedema
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-08-28)Background and aim: Many female cancer survivors who suffer from the consequences of secondary lymphedema experience physical, physiological and social limitations. Many studies have been made of some elements of self-care ... -
Molecular and therapeutic aspects of breast cancer stem cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-08-10)Breast cancer stem cells (BCSCs) are defined as a minor cellular component in the solid tumor, displaying mammary stem cell properties by expressing embryonic stem cell genes. They are usually undergoing self-.‐renewal ... -
Strengthening the pillars of cancer immunotherapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-08-03)The treatment of disease in cancer patients by harnessing the potent mechanisms that exist within the immune system is not a novel approach, and has been first attempted more than a century ago. During the major part of ... -
Evaluation of protein and biological biomarkers in breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-22)Breast cancer is the most common malignancy in women around the world. There have been great improvements in treating the disease and today between 80-90% of the women survive at least 5-years after their primary diagnosis. ...