Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 141-160 of 472
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Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-07-25)The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ... -
Tumour microenvironment in serous ovarian cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-30)Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the ... -
Studies on microglia in tumor biology and neurobiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-24)Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain ... -
Biological and therapeutic aspects of breast cancer progression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-11)Breast cancer is the second leading cause of cancer related death in women worldwide1. Although majority of primary breast cancers are curable with current treatment strategies, treatment outcome of metastatic breast cancer ... -
Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-28)The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, ... -
Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-07)Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of ... -
Exploring disease biomarkers and mechanisms using metabolomics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-03-14)A metabolome is the complete set of small molecules or metabolites present in a biological system. It is the result of internal, genetically determined processes, as well as external factors. The metabolome can consequently ... -
Molecular aspects of tumor development and treatment for small intestinal neuroendocrine tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-01-09)Small intestinal neuroendocrine tumors (SI-NETs) may cause symptoms due to excess secretion of hormones and peptides. The molecular mechanisms behind development of SINETs are not well understood. Copy number alterations, ... -
Ductal adenocarcinoma of the prostate : a morphological, immunohistochemical and genetic study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-11-16)Ductal adenocarcinoma of the prostate (DAC) is the second most common prostate cancer subtype. Patients with DAC often present at an advanced clinicopathological stage, with or without metastases. Patients have a high rate ... -
Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-10-05)Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through ... -
Stroma and vessel characteristics in cancer : impact on prognosis and response to treatment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-09-26)A series of pre-clinical and clinical studies imply vessel and pericyte status as determinants of tumor growth, metastasis and response to treatment. These studies thus imply biomarkerpotential of these features. Earlier ... -
Unravelling molecular mechanisms underlying therapy resistance in cutaneous melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-09-07)For many years the standard treatment of advanced metastatic melanoma with chemotherapeutic agents, including temozolomide (TMZ) and dacarbazine (DTIC), has been unsuccessful. The paradigm shift in melanoma treatment ... -
Stereotactic body radiation therapy of lung tumours : clinical and dosimetric aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-08-29)The general aim of this thesis was to increase the knowledge regarding some clinical and methodological aspects, relevant in view of toxicity as well as tumour control, in stereotactic body radiation therapy (SBRT) of lung ... -
Therapeutic response in human cancers : the dual role of STAT signalling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-08-08)STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects ... -
Studies on the roles of stromal CXCL14 in tumor growth, progression and metastasis formation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-05-27)Cancer consists of several diseases that are characterized by accumulation of genetic and epigenetic alterations that provide cells with certain capabilities to form tumors. Among these acquired capabilities are enhanced ... -
Radiotherapy in prostate cancer : information, quality of life and prostate volume
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-05-04)Prostate cancer (PC) is the most widespread form of cancer among men in Sweden, with an annual incidence of approximately 10,000 new cases. Treatment of localized prostate cancer is controversial. Curative intended treatments ... -
Unwrapping the role of WRAP53β in DNA damage response
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-04-29)WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal ... -
Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-04-29)Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases ... -
Human papillomavirus infection in healthy youth and in hypopharyngeal cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-04-22)The aim of this thesis was to follow the prevalence of human papillomavirus in the oral cavity and in the cervix in youth during the period of 2008-2015, a period when HPV vaccination was gradually introduced to young girls ... -
Regulatory mechanisms contributing to the homeostasis of normal and malignant hematopoietic cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2016-04-19)Bone marrow is the site of origin of diverse population of hematological cells with lineage specific function. The different lineages of cells originate from a common progenitor that has a strong self-renewable capability ...