Doktorsavhandlingar / Doctoral Theses - K2 (MedS): Recent submissions
Now showing items 181-200 of 761
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The roles of microRNAs in skin wound healing
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-15)Skin is an essential biological barrier of the human body, and wound healing is the fundamental physiological process to keep its integrity. Chronic non-healing wounds are growing socioeconomic and health concerns, which ... -
Evaluation of immunological markers for the diagnosis of active and latent tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-21)Tuberculosis (TB) is the single deadliest infectious disease in the world and around one fourth of the global population is estimated to be latently infected with Mycobacterium tuberculosis (Mtb). The World Health Organization ... -
On lymph node based immunotherapy of cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-20)Cancer Immunotherapy based on one’s own immune system to fight cancer is emerging as an important treatment option for advanced stage diseases. The earliest attempts of cancer therapy based on the provocation of the immune ... -
What is the function of B cells in experimental atherosclerosis?
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-14)Cardiovascular disease is one of the leading causes of death worldwide. A major cause is atherosclerosis, which is a chronic inflammatory disease of medium and large size arteries characterized by the accumulation of ... -
Patient safety at emergency departments : challenges with crowding, multitasking and interruptions
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)Several challenges with patient safety in the emergency department (ED) context have been previously identified, and some commonly mentioned are crowding, multitasking, and interruptions. The ED is a complex, high-risk ... -
Gene expression profiling in autoimmune diseases : a story of ups and downs
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)Autoimmune diseases are believed to arise from a combination of genetic and environmental factors that affect normal function of immune cells. In this thesis, we studied the functional role of genetic variants, in peripheral ... -
Novel treatment strategies for multidrug-resistant tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug-resistant tuberculosis (MDR-TB) has further ... -
Stable high-sensitivity cardiac troponin T levels and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ... -
Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-09)Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages ... -
Epidemiological studies on diverticular disease of the colon
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)Objective: The aims of this thesis were to evaluate if there is an association between diverticular disease and colorectal cancer (Paper I), to assess any genetic contribution to the occurrence of diverticular disease ... -
Tuberculosis control in Sweden
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)Sweden is a low tuberculosis (TB) incidence country with an incidence of 5.3 cases per 100 000 inhabitants 2017. The majority of new TB cases in Sweden are diagnosed among migrants from high TB incidence countries. Data ... -
Heart failure : role of metabolic biomarkers, ejection fraction, and sex
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-30)Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range ... -
Epidemiological and pathophysiological studies on diverticular disease in the colon
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-30)Background: Diverticular disease of the colon is common and is associated with a high and increasing societal burden with great economical and human costs. Prevalence increases with age and with an overall aging population, ... -
FAM167A-BLK is a susceptibility locus in autoimmune diseases : characterization of the FAM167 gene family
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-26)Autoimmune diseases are complex multifactorial diseases, and their pathogenesis is only partially understood, but both genetic, as well as environmental factors, have been correlated to an increased risk for the diseases. ... -
Anti-citrulline immunity in rheumatoid arthritis : characterization of peptide-HLA interactions and CD4+ T cell responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-25)Rheumatoid Arthritis (RA) is a complex, systemic autoimmune disorder characterized by chronic inflammation in small joints in hands and feet. It is a common disease that if untreated leads to joint destruction, disability, ... -
Effects of a structured lifestyle program for individuals with high cardiovascular risk
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-19)Cardiovascular disease (CVD) is the leading cause of death in Sweden as well as in the rest of the world. CVD is mainly caused by unhealthy lifestyle habits and lifestyle-related risk factors. National and international ... -
Locus specific DNA methylation in human immunological responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-18)All cells in the human body contains the same genome. Yet, there are hundreds of different cell types, with widely different phenotype, and function. The differential gene expression leading to this diversity is tightly ... -
Adaptive immunity in urothelial cancer : molecular and clinical aspects
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-05)In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ... -
Antibody responses to Plasmodium falciparum as markers of exposure and tools to monitor malaria transmission
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-28)Plasmodium falciparum malaria has the highest death toll of all human parasitic diseases and nearly half of the global population is living at risk of infection. Reducing the malaria burden with the goal of achieving ... -
The role of adjuvant-induced innate immune activation in shaping vaccine responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-27)Adjuvants are components added to non-live vaccine formulations to enhance the effect of the vaccine by alerting the immune system to initiate a response against the vaccine. Powerful new adjuvants will be critical for the ...