Doktorsavhandlingar / Doctoral Theses - K2 (MedS): Recent submissions
Now showing items 161-180 of 761
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Tracing the interplay between cellular metabolism and cell cycle
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-13)Cancer cells are more vulnerable to targeting during S-G2-M cell cycle phases due to common deregulations in cell cycle checkpoint mechanisms. Most common cancer drugs target processes in the S-G2-M phases, often causing ... -
Breast cancer : brain metastases and treatment aspects
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)Background: In Sweden breast cancer is the most common malignant cancer disease among women, with 8000 new individual cases each year. The prognosis is generally very good, but nevertheless many patients still die of breast ... -
Identification and functional characterization of irritable bowel syndrome (IBS) risk genes and variants
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)As one of the most prevalent functional gastrointestinal disorders (FGIDs), irritable bowel syndrome (IBS) affects more than 10% of the general population worldwide with a higher prevalence in women. The primary clinical ... -
Remote ischemic conditioning to protect the heart in myocardial infarction : therapeutic intervention and underlying mechanisms
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-03)Background: Urgent reperfusion of the occluded coronary artery halts the ischemic insult to the myocardium and is the single most important action to limit infarct size in ST-elevation myocardial infarction. However, ... -
Cellular and molecular factors in the pathogenesis of systemic autoimmunity and comorbidities
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-02)Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are systemic rheumatic autoimmune diseases having a major impact on patient’s wellbeing. Besides fatigue, pain and direct damage to exocrine glands in SS, and ... -
Suicide, violent crime, divorce and mortality in deployed military veterans
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-30)It has long been known that individuals deployed to war and conflict zones might suffer from mental health problems after returning home. This thesis investigated suicide, violent crime, divorce and marriage in deployed ... -
The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-29)Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, ... -
Mast cell development in health and systemic mastocytosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-24)Hematopoietic progenitors in the bone marrow differentiate into several immune cells, including mast cells. Mast cell progenitors leave the bone marrow, circulate through the blood, and home to the periphery where they ... -
Physical function, physical activity and quality of life in systemic sclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-11)Background and aims: Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by fibrosis, vasculopathy and immune system activation. There is a dearth of knowledge how different subphenotypes such as ... -
The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-05)Background: The rotavirus causes the most severe cases of viral gastroenteritis in small children worldwide, resulting in both high morbidity and mortality. The World Health Organization has recommended vaccination against ... -
Immune mechanisms that determine the quality of antibody responses to vaccines
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-03)Effective vaccines for many dangerous infectious diseases are still lacking. An improved understanding of the mechanisms that determine the quality of vaccine responses is essential to guide future attempts to design ... -
T cell signatures and modulation by regulatory T cells
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-03-22)CD4 T cells are crucial coordinators of protective immune responses against microbes and tumors. However, immune responses misdirected towards self-antigens are the hallmarks of autoimmune diseases. Regulatory T cells ... -
New insights on type 2 immunity key drivers : mast cells and group 2 innate lymphoid cells
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)Type 2 immune responses are characterized by the production of cytokines IL-4, IL-5 and IL-13. They are known to have crucial physiological and pathophysiological functions in the body. Data from recent studies indicate ... -
Gene environment-interaction and cardiovascular phenotype in obesity and diabetes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical ... -
Following the white rabbit : release and regulation of HMGB1 in inflammation
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-21)Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein ... -
Drug utilization in children with asthma : methodological approaches and practical implications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-12)There is limited research on drug utilization among children, despite them representing 20% of the total population in Europe. In the Priority Medicines report, the World Health Organization suggested that drug utilization ... -
Mechanisms of type I interferons in autoimmunity and cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-01)Interferons (IFNs) were first described in the 1950’s and has since been characterized as potent inducers of pathogen defense mechanisms. Since then, researchers have uncovered a depth of mechanisms in the IFN system ... -
Sex differences in adverse drug events from cardiovascular medicines in routine care
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-31)In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature ... -
Immunological aspects of migration and tolerance
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-25)The actions of the immune system are highly dependent on locality for development, memory imprinting, surveillance and effector functions. Migratory processes are therefore essential for maintaining immunological integrity ... -
Screening strategies for dysglycaemia in relation to cardiovascular risk
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-16)Background: Dysglycaemia, defined as type 2 diabetes (T2DM) or impaired glucose tolerance (IGT), is a major risk factor for cardiovascular disease (CVD). Dysglycaemia and CVD together account for more than half of worldwide ...