Doktorsavhandlingar / Doctoral Theses - K2 (MedS): Recent submissions
Now showing items 121-140 of 761
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Malaria in travellers and migrants : disease severity and long term effects
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-11)Malaria is a potentially fatal infection, where prompt and correct management is crucial for the outcome. Despite international efforts to reduce transmission, there are over 200 million new malaria cases with approximately ... -
Immunometabolic regulation of atherosclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-31)Ischaemic heart disease and stroke are the most common causes of death in the world, both diseases being manifestations of atherosclerotic cardiovascular disease. Atherosclerosis is a slow process initialized by the retention ... -
Etiology and risk factors of febrile neutropenia in children during cancer treatment
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-26)Side effects due to chemotherapy is still a major issue during cancer treatment. Febrile neutropenia and associated microbiological defined infections (MDIs) are dreaded complications, and still a cause of death during ... -
Prostate cancer prognostication based on clinical and histopathological tumor features
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-25)Prostate cancer is the second most common cancer in men worldwide. Of almost 1.3 million newly diagnosed men per year, up to 80% will have localized disease with a characteristically prolonged natural history. Risk ... -
Respiratory mononuclear phagocytes during steady state and sarcoidosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-25)Each day, our lungs inhale thousands of liters of air containing not only essential oxygen but also smoke particles, dust, allergens, and potentially dangerous pathogens. In order to tolerate harmless antigens and initiate ... -
Next in bariatric surgery : the role of lifestyle and adequate information to improve patients’ quality of life and health
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-12)Aim: The overall aim of this doctoral thesis is to increase the knowledge about how behavioral modification and information can improve the individual results following bariatric surgery or conventional weight loss ... -
Bridging innate and adaptive immunity in cardiovascular disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-10)Cardiovascular disease is the leading cause of death and morbidity in the world. Myocardial infarction and stroke constitute the main manifestations of atherosclerosis that lead to the majority of cardiovascular events. ... -
Understanding the role of non-coding RNAs in skin homeostasis and cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-04)The epidermis is a stratified epithelium with continuous self-renewing capacity. As the outermost layer of our body, it provides a protective barrier against external trauma, produces pigmentation, and keeps the skin ... -
Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-26)Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a ... -
Methods for studying memory B-cell immunity against malaria
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)Plasmodium falciparum malaria remains one of the world’s deadliest infectious diseases and the search for an effective vaccine is highly warranted. Memory B cells (MBCs) and the antibodies they produce, once activated, is ... -
Psoriasis : from transcriptome to miRNA function and biomarkers
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)Psoriasis is a chronic inflammatory, immune-mediated skin condition that affects in average 2 to 3% of the world population, phenotypically characterized by red and scaly plaques on the skin of affected patients. It is a ... -
Factors associated with HIV susceptibility in the female genital tract
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-13)The majority of new HIV infections in women are transmitted through vaginal intercourse where the female genital tract (FGT) functions as the portal of viral entry. The aim of this thesis was to characterize mucosal factors ... -
Epithelial barrier protection : implications for HIV susceptibility
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-04-24)The majority of HIV infections today occur through sexual HIV transmission. The female genital mucosa offers a barrier against incoming pathogens. Although, studies show that the vaginal microbiome, co-current infections ... -
Lifestyle and infections : an epidemiological approach on the role of obesity, physical activity, sleep and stress
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-04-14)The immune system plays a fundamental role in defending the human body from external pathogens. Some individuals, however, have a weaker immune system leading to more frequent infections. Infections are associated with ... -
Social inequalities in access to child healthcare services : an international comparative perspective
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-04-08)Universal access to child healthcare services is of greatest importance and a common goal of many countries in Europe and elsewhere. Thus, every child should be able to receive the healthcare they need, irrespective of ... -
Molecular structure of the human skin’s barrier : elucidation, formation and utilization
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-04-08)The main focus of this study is the permeation barrier of human skin. Original cryo-electron microscopic images from near native samples of human epidermis was used as the guiding reference to assemble in silico molecular ... -
Elucidating the role of DNA damage and human cytomegalovirus in medulloblastoma and glioblastoma
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-03-05)The most common primary malignant brain tumor in children is Medulloblastoma, while Glioblastoma is the most common in adults. Treatment for both include some combination of surgery, radiation therapy, and chemotherapy. ... -
Sarcoidosis : expression of cell regulatory markers and the influence of patient phenotype on bronchoalveolar lavage cell differential counts
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-02-21)Sarcoidosis is a systemic inflammatory disease that can affect almost any organ, but the respiratory system is affected in more than 90% of the cases. To elicit an immune response, an antigen(s) is processed by antigen-presenting ... -
Testosterone : of importance in patients with dysglycemia and cardiovascular disease?
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-02-21)Background: Testosterone has been associated with cardiovascular (CV) health in men and women with or without diabetes. There are however conflicting results which warrant further investigations to understand if testosterone ... -
Hemodynamics, echocardiography, and biomarkers in different heart failure phenotypes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-02-12)Background: Heart failure (HF) is a major health problem affecting millions of patients worldwide and is associated with impaired quality of life and poor prognosis. Different approaches including invasive and non-invasive ...