Doktorsavhandlingar / Doctoral Theses - K2 (MedS): Recent submissions
Now showing items 101-120 of 761
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Thrombotic and cardiac disease in the antiphospholipid syndrome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-04-16)The antiphospholipid syndrome (APS) is a highly heterogeneous disease that presents with obstetric complications and/or thromboembolic events that can hit any side of the vascular tree in an unpredictable way. The common ... -
Neural control of inflammation
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-03-31)Pioneering research on neural control of inflammation has paved the way for new and exciting developments in the growing field of bioelectronic medicine. In the past couple of decades, pre-clinical research on the role of ... -
Immunopathogenic mechanisms in primary Sjögren’s syndrome
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-03-30)Primary Sjögren’s syndrome is a systemic autoimmune disease primarily affecting salivary and lacrimal glands, but patients may also have other organ involvement. Development of Sjögren’s syndrome has been associated with ... -
Exploring lymphocyte subsets, autoantibodies and the effect of B cell targeted therapies in rheumatic diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-03-12)Nowadays, around 100 different diseases sort under the umbrella of rheumatic diseases(1). They involve different mechanisms and symptoms engaging joints, tendons, ligaments, bones, muscles but also vital organs like the ... -
Sex and gender aspects in drug utilization
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-03-04)Drug prescribing is one of the most important processes in healthcare and drugs are also commonly used in the population. Drug use differs between men and women and descriptive reports of sex differences in drug use have ... -
Molecular insights into the pathogenesis of B-cell and myeloid malignancies : therapeutic implications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-03-03)Hematological malignancies originate from hematopoietic cells in the bone marrow or the lymphatic system. In this thesis, I study the molecular pathogenesis of Hodgkin lymphoma (HL), mantle cell lymphoma (MCL), and ... -
Demand and capacity imbalance in the emergency department, and patient outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-02-16)Background: An emergency department (ED) is always open and continuously needs to balance the inflow and demand for emergency service with available capacity. When demand exceeds the available capacity of an ED, it is ... -
Epidemiological aspects of sarcoidosis : risk factors and long-term consequences
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-01-27)Sarcoidosis is a systemic inflammatory disease of unknown etiology in which granulomatous lesions form mostly in the lungs and the lymphatic system of patients. Although more than a century has passed since sarcoidosis was ... -
Inflammatory arthritis and pregnancy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-01-14)The aim of this thesis was to add to the existing knowledge of how inflammatory arthritis disease affects pregnancy outcomes. In particular, the aim was to describe and study the effects of a diagnosis of juvenile idiopathic ... -
Long-term survival and survivorship in non-Hodgkin lymphoma patients in Sweden
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-12-11)Non-Hodgkin lymphoma (NHL) is one of the top ten most common cancer types in Sweden. Although sometimes referred to as one disease, NHL is truly an umbrella term representing a heterogeneous group of diseases with varying ... -
Common medications in the risk and prognosis of lymphoid neoplasms and epidemiology of primary CNS lymphoma
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-30)Lymphoid neoplasms are malignancies arising from the lymphocyte, and include lymphoma subtypes, chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). It is a heterogenous group of diseases, with different molecular ... -
Dispatch of lay responders to out-of-hospital cardiac arrests
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-27)Background and aim: Out-of-hospital cardiac arrest (OHCA) remains a major public-health problem affecting around 300 000 Europeans each year. If treatment is not started within a couple of minutes the chances of survival ... -
Genetics of systemic autoimmunity and comorbidities
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-26)Sjögren‘s syndrome (SS) is a systemic autoimmune disease that typically affects the salivary and lacrimal glands leading to dry eyes and dry mouth, but the patients may also have systemic involvement. Most patients with ... -
Viral infections in immunosuppressed patients with hematological malignancies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-12)Acute or reactivated viral infections are common in patients who are immunosuppressed because of hematopoietic stem cell transplantation (HSCT) or chemotherapy due to hematological malignancies. The severity of the ... -
Lung cancer in Sweden : incidence, diagnosis and survival
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-29)Globally, lung cancer is the most commonly diagnosed form of cancer, as well as the number one cancer-related cause of death. This thesis includes four population-based studies that considered different aspects of lung ... -
The role of the G protein-coupled receptor ChemR23 in cardiovascular inflammation
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-28)Cardiovascular inflammation is a biological process characterized by the immune cell response to harmful stimuli within the cardiovascular system, wherein homeostasis is reestablished by neutralizing the insult and promoting ... -
Studies on pathogenesis, clinical features and comorbidities of idiopathic inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-28)Idiopathic inflammatory myopathies (IIM), a group of rare chronic inflammatory disorders, are characterized by a broad spectrum of clinical manifestations with high morbidity and mortality. The pathogenesis of IIM is largely ... -
Socioeconomic status and out-of-hospital cardiac arrest
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-15)Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of death. Around 6000 people in Sweden suffer OHCA each year and only about 10% survive. Historically, the focus of OHCA research has been on different ... -
The oncogenic role of histone chaperone ASF1 proteins in solid tumors
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-02)Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment ... -
Implantable cardioverter defibrillator treatment in patients with hypertrophic cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-17)Background: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with various clinical manifestations, including sudden cardiac death, which can be prevented by an implantable cardioverter defibrillator (ICD). Aims: ...