Now showing items 1-20 of 654

    • Inflammatory arthritis and pregnancy 

      Remaeus, Katarina (Inst för medicin, Solna / Dept of Medicine, Solna, 2021-01-14)
      The aim of this thesis was to add to the existing knowledge of how inflammatory arthritis disease affects pregnancy outcomes. In particular, the aim was to describe and study the effects of a diagnosis of juvenile idiopathic ...
    • Long-term survival and survivorship in non-Hodgkin lymphoma patients in Sweden 

      Ekberg, Sara (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-12-11)
      Non-Hodgkin lymphoma (NHL) is one of the top ten most common cancer types in Sweden. Although sometimes referred to as one disease, NHL is truly an umbrella term representing a heterogeneous group of diseases with varying ...
    • Common medications in the risk and prognosis of lymphoid neoplasms and epidemiology of primary CNS lymphoma 

      Brånvall, Elsa (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-30)
      Lymphoid neoplasms are malignancies arising from the lymphocyte, and include lymphoma subtypes, chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). It is a heterogenous group of diseases, with different molecular ...
    • Dispatch of lay responders to out-of-hospital cardiac arrests 

      Berglund, Ellinor (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-27)
      Background and aim Out-of-hospital cardiac arrest (OHCA) remains a major public-health problem affecting around 300 000 Europeans each year. If treatment is not started within a couple of minutes the chances of ...
    • Genetics of systemic autoimmunity and comorbidities 

      Thorlacius, Guðný Ella (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-26)
      Sjögren‘s syndrome (SS) is a systemic autoimmune disease that typically affects the salivary and lacrimal glands leading to dry eyes and dry mouth, but the patients may also have systemic involvement. Most patients with ...
    • Viral infections in immunosuppressed patients with hematological malignancies 

      Gustafsson, Igge (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-12)
      Acute or reactivated viral infections are common in patients who are immunosuppressed because of hematopoietic stem cell transplantation (HSCT) or chemotherapy due to hematological malignancies. The severity of the ...
    • Lung cancer in Sweden : incidence, diagnosis and survival 

      Löfling, Lukas (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-29)
      Globally, lung cancer is the most commonly diagnosed form of cancer, as well as the number one cancer-related cause of death. This thesis includes four population-based studies that considered different aspects of ...
    • The role of the G protein-coupled receptor ChemR23 in cardiovascular inflammation 

      Artiach Castañón, Gonzalo (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-28)
      Cardiovascular inflammation is a biological process characterized by the immune cell response to harmful stimuli within the cardiovascular system, wherein homeostasis is reestablished by neutralizing the insult and promoting ...
    • Studies on pathogenesis, clinical features and comorbidities of idiopathic inflammatory myopathies 

      Notarnicola, Antonella (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-28)
      Idiopathic inflammatory myopathies (IIM), a group of rare chronic inflammatory disorders, are characterized by a broad spectrum of clinical manifestations with high morbidity and mortality. The pathogenesis of IIM is ...
    • Socioeconomic status and out-of-hospital cardiac arrest 

      Jonsson, Martin (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-15)
      Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of death. Around 6000 people in Sweden suffer OHCA each year and only about 10% survive. Historically, the focus of OHCA research has been on different ...
    • The oncogenic role of histone chaperone ASF1 proteins in solid tumors 

      Wu, Yujiao (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-02)
      Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment ...
    • Implantable cardioverter defibrillator treatment in patients with hypertrophic cardiomyopathy 

      Magnusson, Peter (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-17)
      Background: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with various clinical manifestations, including sudden cardiac death, which can be prevented by an implantable cardioverter defibrillator (ICD). Aims: ...
    • Malaria in travellers and migrants : disease severity and long term effects 

      Wyss, Katja (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-11)
      Malaria is a potentially fatal infection, where prompt and correct management is crucial for the outcome. Despite international efforts to reduce transmission, there are over 200 million new malaria cases with approximately ...
    • Immunometabolic regulation of atherosclerosis 

      Berg, Martin (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-31)
      Ischaemic heart disease and stroke are the most common causes of death in the world, both diseases being manifestations of atherosclerotic cardiovascular disease. Atherosclerosis is a slow process initialized by the retention ...
    • Etiology and risk factors of febrile neutropenia in children during cancer treatment 

      Wahlund, Martina (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-26)
      Side effects due to chemotherapy is still a major issue during cancer treatment. Febrile neutropenia and associated microbiological defined infections (MDIs) are dreaded complications, and still a cause of death during ...
    • Prostate cancer prognostication based on clinical and histopathological tumor features 

      Zelić, Renata (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-25)
      Prostate cancer is the second most common cancer in men worldwide. Of almost 1.3 million newly diagnosed men per year, up to 80% will have localized disease with a characteristically prolonged natural history. Risk ...
    • Respiratory mononuclear phagocytes during steady state and sarcoidosis 

      Lepzien, Rico (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-25)
      Each day, our lungs inhale thousands of liters of air containing not only essential oxygen but also smoke particles, dust, allergens, and potentially dangerous pathogens. In order to tolerate harmless antigens and initiate ...
    • Next in bariatric surgery : the role of lifestyle and adequate information to improve patients’ quality of life and health 

      Hult, Mari (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-12)
      Aim: The overall aim of this doctoral thesis is to increase the knowledge about how behavioral modification and information can improve the individual results following bariatric surgery or conventional weight loss ...
    • Bridging innate and adaptive immunity in cardiovascular disease 

      Karadimou, Glykeria (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-10)
      Cardiovascular disease is the leading cause of death and morbidity in the world. Myocardial infarction and stroke constitute the main manifestations of atherosclerosis that lead to the majority of cardiovascular events. ...
    • Understanding the role of non-coding RNAs in skin homeostasis and cancer 

      Das Mahapatra, Kunal (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-04)
      The epidermis is a stratified epithelium with continuous self-renewing capacity. As the outermost layer of our body, it provides a protective barrier against external trauma, produces pigmentation, and keeps the skin ...