Doktorsavhandlingar / Doctoral Theses - K2 (MedS): Recent submissions
Now showing items 21-40 of 759
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Prediction and monitoring of in-hospital cardiac arrest
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-16)Background: In-hospital cardiac arrest (IHCA) is a global health concern of major importance, associated with a poor prognosis. IHCA is frequently heralded by a deterioration of vital signs, and many cases are considered ... -
Composition and maintenance of skin resident T-cells in health and disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-13)Tissue-resident memory T cells (TRM) reside in healthy skin at sites of previous infections. Upon re-infection, TRM cells rapidly respond by initiating tissue inflammation and exert effector functions to eliminate ... -
Colorectal cancer in inflammatory bowel disease : aspects on post-colonoscopy colorectal cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-27)Colorectal cancer (CRC) is the third most common cancer in the world. It is diagnosed by and can be prevented with colonoscopy combined with polyp removal. A post-colonoscopy CRC (PCCRC) is a cancer detected within 3 years ... -
"It's not a quick fix" : consequences of weight loss during life and experiences of weight regain after bariatric surgery
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-18)Maintenance of weight loss is challenging for most people who intentionally lose weight. Complex factors interact with each other and obstruct weight management. This thesis focuses on the consequences of weight loss ... -
Etiology and prognosis of spondyloarthropathies using family-based epidemiological methods
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-13)The spondyloarthropathies (SpA) are a group of chronic inflammatory diseases that share several disease characteristics such as inflammation of entheses and extramusculoskeletal manifestations like uveitis, psoriasis, and ... -
Childhood-onset inflammatory bowel disease-health care use, impact on growth and school achievements
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-08-16)The aim of this thesis was to explore the Impact of Inflammatory bowel disease (IBD) on growth and school achievements. We also assessed the Incidence and health care use of patients with very early-onset IBD (VEO-IBD). ... -
Genetic and environmental influences on multiple sclerosis complications and aetiology
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-22)Multiple sclerosis (MS) is an immune mediated, neurological disease that results in a chronic accumulation of disability over time. Many advances in the understanding, diagnosis and treatment of MS have been made, yet ... -
Treatment optimisation of multidrug-resistant tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-22)A successful treatment outcome is seen in only 60% of persons treated for multidrugresistant tuberculosis (MDR-TB) worldwide, defined as resistance to both rifampicin and isoniazid. To improve these disturbingly low ... -
Risk factors and outcomes in inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-05-04)Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available ... -
Studies of pathophysiological mechanisms and oral cavity manifestations in chronic inflammatory diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-04-14)Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a 9:1 female predominance where many genetic and clinical characteristics overlap with other inflammatory conditions such as rheumatoid arthritis (RA). ... -
Studies on autoantibodies and inflammatory markers in patients with idiopathic inflammatory myopathies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-04-05)Idiopathic Inflammatory myopathies (IIM), commonly known as myositis, are chronic autoimmune diseases characterized by low muscle strength and low muscle endurance as main features. However, a high number of patients may ... -
Morbidity and childbirth in myeloproliferative neoplasms
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-31)Myeloproliferative neoplasms (MPN) are a family of chronic hematologic cancers, characterized by excess proliferation of myeloid cell lineages, or fibrosis of the bone marrow. Patients with MPN generally have a long expected ... -
Dysglycaemia and cardiovascular disease. Aspects on screening, management, and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-24)Background: Dysglycaemia, in this thesis defined as impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), is a major risk factor for cardiovascular disease (CVD). International guidelines recommend screening for ... -
Studies of the immunopathogenesis of arthritis, with an emphasis on the alarmin HMGB1
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-20)Dysregulated inflammatory responses are characterized by the excessive release of endogenous inflammatory molecules, which initiate a chain of reactions, including immune cell infiltration, activation, polarization, necrosis, ... -
The T cell phenotype and receptor repertoire in different stages of rheumatoid arthritis : an immunological timeline
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-15)Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by symmetrical inflammation in hands and feet. Antibodies recognizing citrullinated protein (ACPA) and/or rheumatoid factor (RF) are found in most ... -
Agnostic studies in epidemiology
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-24)In epidemiology there has been an consistent effort to construct refined methods aiming towards the ability to draw casual inference between an exposure and an outcome. This thesis, partly inspired by the genome-wide ... -
The effect of Plasmodium infection on cellular aging in humans
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-17)Telomeres play an essential role in maintaining chromosomal integrity and stability. Telomere shortening is part of the natural aging process, nevertheless, accelerated telomere shortening has been linked to chronic diseases ... -
Nutrition in advanced cancer care : a clinical perspective
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-16)Adequate nutrition is an essential part in all stages of cancer care. By optimizing the nutrition care the benefits include increased tolerance to treatment as well as decreased mortality. Understanding how aspects of ... -
Diffuse large B-cell lymphoma : population-based studies of relapse and cardiac complications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-15)Diffuse large B-cell lymphoma (DLBCL) is an aggressive life-threatening disease, but it is often possible to cure with immunochemotherapy. Not responding to primary treatment or having a relapse is associated with poor ... -
Understanding the role of regulatory RNAs in human skin wound healing
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-02-14)Human skin wound healing is characterized by four phases in a timely manner, including hemostasis, inflammation, proliferation, and remodeling. Various cell types are involved in the biological process. Keratinocytes ...