Now showing items 1-20 of 611

  • New insights on type 2 immunity key drivers : mast cells and group 2 innate lymphoid cells 

    Ravindran, Avinash (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)
    Type 2 immune responses are characterized by the production of cytokines IL-4, IL-5 and IL-13. They are known to have crucial physiological and pathophysiological functions in the body. Data from recent studies indicate ...
  • Gene environment-interaction and cardiovascular phenotype in obesity and diabetes 

    Hussain, Shafaat (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)
    Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical ...
  • Following the white rabbit : release and regulation of HMGB1 in inflammation 

    Sowinska, Agnieszka (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-21)
    Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein ...
  • Drug utilization in children with asthma : methodological approaches and practical implications 

    Dahlén, Elin (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-12)
    There is limited research on drug utilization among children, despite them representing 20% of the total population in Europe. In the Priority Medicines report, the World Health Organization suggested that drug utilization ...
  • Mechanisms of type I interferons in autoimmunity and cancer 

    Nyberg, William (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-01)
    Interferons (IFNs) were first described in the 1950’s and has since been characterized as potent inducers of pathogen defense mechanisms. Since then, researchers have uncovered a depth of mechanisms in the IFN system ...
  • Sex differences in adverse drug events from cardiovascular medicines in routine care 

    Rydberg, Diana (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-31)
    In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature ...
  • Immunological aspects of migration and tolerance 

    Arkestål, Kurt (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-25)
    The actions of the immune system are highly dependent on locality for development, memory imprinting, surveillance and effector functions. Migratory processes are therefore essential for maintaining immunological integrity ...
  • Screening strategies for dysglycaemia in relation to cardiovascular risk 

    Shahim, Bahira (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-16)
    Background: Dysglycaemia, defined as type 2 diabetes (T2DM) or impaired glucose tolerance (IGT), is a major risk factor for cardiovascular disease (CVD). Dysglycaemia and CVD together account for more than half of worldwide ...
  • The roles of microRNAs in skin wound healing 

    Li, Xi (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-15)
    Skin is an essential biological barrier of the human body, and wound healing is the fundamental physiological process to keep its integrity. Chronic non-healing wounds are growing socioeconomic and health concerns, which ...
  • Evaluation of immunological markers for the diagnosis of active and latent tuberculosis 

    Wahren Borgström, Emilie (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-21)
    Tuberculosis (TB) is the single deadliest infectious disease in the world and around one fourth of the global population is estimated to be latently infected with Mycobacterium tuberculosis (Mtb). The World Health Organization ...
  • On lymph node based immunotherapy of cancer 

    Zhang, Lu (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-20)
    Cancer Immunotherapy based on one’s own immune system to fight cancer is emerging as an important treatment option for advanced stage diseases. The earliest attempts of cancer therapy based on the provocation of the ...
  • What is the function of B cells in experimental atherosclerosis? 

    Centa, Monica (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-14)
    Cardiovascular disease is one of the leading causes of death worldwide. A major cause is atherosclerosis, which is a chronic inflammatory disease of medium and large size arteries characterized by the accumulation of ...
  • Patient safety at emergency departments : challenges with crowding, multitasking and interruptions 

    Berg, Lena (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)
    Several challenges with patient safety in the emergency department (ED) context have been previously identified, and some commonly mentioned are crowding, multitasking, and interruptions. The ED is a complex, high-risk ...
  • Gene expression profiling in autoimmune diseases : a story of ups and downs 

    Houtman, Miranda (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)
    Autoimmune diseases are believed to arise from a combination of genetic and environmental factors that affect normal function of immune cells. In this thesis, we studied the functional role of genetic variants, in ...
  • Novel treatment strategies for multidrug-resistant tuberculosis 

    Davies Forsman, Lina (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)
    Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug- resistant tuberculosis (MDR-TB) has further ...
  • Stable high-sensitivity cardiac troponin T levels and outcomes 

    Roos, Andreas (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)
    Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ...
  • Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections 

    Isendahl, Joakim (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-09)
    Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages ...
  • Epidemiological studies on diverticular disease of the colon 

    Granlund, Johan (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)
    Objective: The aims of this thesis were to evaluate if there is an association between diverticular disease and colorectal cancer (Paper I), to assess any genetic contribution to the occurrence of diverticular disease ...
  • Tuberculosis control in Sweden 

    Jonsson, Jerker (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)
    Sweden is a low tuberculosis (TB) incidence country with an incidence of 5.3 cases per 100 000 inhabitants 2017. The majority of new TB cases in Sweden are diagnosed among migrants from high TB incidence countries. Data ...
  • Heart failure : role of metabolic biomarkers, ejection fraction, and sex 

    Faxén, Ulrika Ljung (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-30)
    Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range ...