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  • Prediction of individuals at high absolute risk of esophageal squamous cell carcinoma 

    Wang, Qiaoli; Lagergren, Jesper; Xie, Shao-Hua (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgerySchool of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom, 2020-03-18)
    Background and Aims: This study aimed to develop a prediction model for identifying individuals at high absolute risk of esophageal squamous cell carcinoma (ESCC) for endoscopic screening at a curable stage based on readily ...
  • Global time trends in the incidence of esophageal squamous cell carcinoma 

    Wang, Qiao-Li; Xie, Shao-Hua; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)
    Background & Aims: Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer worldwide (90%). We aimed to provide an update of the global temporal trends in the incidence of ...
  • Association between levels of sex hormones and risk of esophageal adenocarcinoma and Barrett’s esophagus 

    Xie, Shaohua; Fang, Rui; Huang, Mingtao; Dai, Juncheng; Thrift, Aaron P.; Anderson, Lesley A.; Chow, Wong-Ho; Bernstein, Leslie; Gammon, Marilie D.; Risch, Harvey A.; Shaheen, Nicholas J.; Reid, Brian J.; Wu, Anna H.; Iyer, Prasad G.; Liu, Geoffrey; Corley, Douglas A.; Whiteman, David C.; Caldas, Carlos; Pharoah, Paul D.; Hardie, Laura J.; Fitzgerald, Rebecca C.; Shen, Hongbing; Vaughan, Thomas L.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)
    Background & Aims: Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that regulate levels of sex hormones associated ...
  • Association between metformin use and risk of esophageal squamous cell carcinoma in a population-based cohort study 

    Wang, Qiao-Li; Santoni, Giola; Ness-Jensen, Eivind; Lagergren, Jesper; Xie, Shao-Hua (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, NorwayMedical Department, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, NorwaySchool of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom, 2020-03-11)
    Objectives: Esophageal cancer is a highly fatal malignant neoplasm, with two etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal ...
  • Ageing, deep vein thrombosis and male gender predict poor outcome after acute Achilles tendon rupture 

    Domeij-Arverud, Erica; Anundsson, Per; Hardell, Eva; Barreng, Gunilla; Edman, Gunnar; Latifi, Ali; Labruto, Fausto; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patients with acute Achilles tendon rupture (ATR) exhibit prolonged healing, high incidence of deep venous thrombosis (DVT) and a wide variation of functional outcome. This extensive discrepancy in outcome may ...
  • Reduced time to surgery improves patient-reported outcome after achilles tendon rupture. 

    Ackermann, Paul; Edman, Gunnar; Juthberg, Robin; Svedman, Simon (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols, however, ...
  • Prognosis following cancer surgery during holiday periods 

    Lagergren, Jesper; Lagergren, Pernilla; Mattsson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-19)
  • Weekday of cancer surgery in relation to prognosis 

    Lagergren, Jesper; Mattson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced ...
  • Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia ...
  • Recurrence of reflux after laparoscopic antireflux surgery : reply 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
  • Nordic registry-based cohort studies : possibilities and pitfalls when combining Nordic registry data 

    Maret-Ouda, John; Tao, Wenjing; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    Aims: All five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have nationwide registries with similar data structure and validity, as well as personal identity numbers enabling linkage between registries. ...
  • Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux 

    Maret-Ouda, John; Wahlin, Karl; El-Serag, Hashem B.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...
  • Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo) 

    Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)
    PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare ...
  • Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...
  • Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma. 

    Kauppila, Joonas Henrikki; Bogdanoff, Sara; Leppänen, Joni; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo; Huhta, Heikki; Helminen, Olli (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is ...
  • Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer. 

    Kauppila, Joonas Henrikki; Xie, Shaohua; Johar, Asif; Markar, Sheraz; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: The aim of this systematic review and meta-analysis was to compare health-related quality of life (HRQoL) outcomes between minimally invasive and open oesophagectomy for cancer at different postoperative time ...
  • All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study) 

    Ness-Jensen, Eivind; Gottlieb-Vedi, Eivind; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-11)
    OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of ...
  • Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loc 

    Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and ...
  • Quality of life and psychological and gastrointestinal symptoms after cholecystectomy : a population-based cohort study 

    Talseth, Arne; Edna, Tom-Harald; Hveem, Kristian; Lydersen, Stian; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    OBJECTIVE: The study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy. DESIGN: This is a prospective population-based cohort study based ...
  • Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease 

    Ness-Jensen, Eivind; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include ...

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