Now showing items 1-20 of 448

  • Smoking cessation and risk of esophageal cancer by histological type : systematic review and meta-analysis 

    Qiao-Li, Wang; Shao-Hua, Xie; Wen-Tao, Li; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-06)
    Background Tobacco smoking strongly increases risk of esophageal squamous cell carcinoma and moderately increases risk of esophageal adenocarcinoma. How smoking cessation influences esophageal cancer risk across ...
  • Quality of life in patients with thyroid cancer 

    Hedman, Christel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-02)
    Background: The prevalence of differentiated thyroid cancer (DTC) is increasing as a consequence of rising incidence, young age at diagnosis and excellent survival. The established treatment is surgery, followed by radioiodine ...
  • Locally recurrent rectal cancer: aspects on management, surgery and outcome 

    Westberg, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-01)
    Locally recurrent rectal cancer (LRRC) is a severe condition associated with a high morbidity and mortality, affecting about 150-200 people/year in Sweden. After improvements in management and treatment of primary rectal ...
  • Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells 

    Daraio, Teresa (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ...
  • Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity 

    Nylén, Carolina (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ...
  • Health‑related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma 

    Ringborg, Cecilia; Johar, Asif; Lagergren, Jesper; Lagergren, Pernilla; Kauppila, Joonas H (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-04)
    BACKGROUND: The postoperative health-related quality of life (HRQOL) outcomes in patients with gastroesophageal junction (GEJ) adenocarcinoma after gastrectomy and esophagectomy are unclear. The aim was to ...
  • Bone disease and diabetes mellitus 

    Ugarph-Morawski, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-01)
    Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently ...
  • In vivo and in vitro studies of apolipoprotein CIII in diabetes 

    Åvall, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-08-23)
    Apolipoprotein CIII (apoCIII) is an important regulator of lipid metabolism and it is also known to have pro-inflammatory properties. From the point of view of diabetes it is interesting that both insulin deficiency and ...
  • Menopausal hormone therapy and the risk of esophageal and gastric cancer 

    Brusselaers, Nele; Maret-Ouda, John; Konings, Peter; El-Serag, HB; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-24)
    A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ...
  • Diagnosis, treatment and evaluation of chronic venous disease 

    Sinabulya, Helen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-19)
    BACKGROUND AND AIMS: Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) in the Western hemisphere. Recent research shows that the disease encompasses the global population and with ...
  • The risk of mortality following secondary fundoplication in a population-based cohort study 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-16)
    BACKGROUND: Mortality following laparoscopic fundoplication has been found to be negligible. However, some patients require secondary fundoplication, and the risk of mortality following such procedure is ...
  • Psychological distress following oesophageal cancer treatment : is there a need for psychological support? 

    Hellstadius, Ylva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-12)
    Oesophageal cancer is associated with a poor prognosis, an extensive treatment pathway and a difficult recovery process. Previous studies have shown that oesophageal cancer patients suffer from great physical impact of the ...
  • Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site 

    Lagergren, Jesper; Andersson, Gunnar; Talbäck, Mats; Drefahl, Sven; Bihagen, Erik; Härkönen, Juho; Feychting, Maria; Ljung, Rickard (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-10)
    BACKGROUND: Marital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these ...
  • Why oesophageal adenocarcinoma is occurring more frequently 

    Doorakkers, Eva; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)
    The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk ...
  • Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma 

    Kauppila, Joonas; Huhta, Heikki; Helminen, Olli; Palomäki, Sami; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-25)
    Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in ...
  • Extent of lymphadenectomy and prognosis after esophageal cancer surgery 

    Lagergren, Jesper; Mattsson, Fredrik; Zylstra, Janine; Chang, Fuju; Gossage, James; Mason, Robert; Lagergren, Pernilla; Davies, Andrew (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    IMPORTANCE: The prognostic role of the extent of lymphadenectomy during surgery for esophageal cancer is uncertain and requires clarification. OBJECTIVE: To clarify whether the number of removed lymph nodes influences ...
  • Weekday of oesophageal cancer surgery in relation to early postoperative outcomes in a nationwide Swedish cohort study 

    Lagergren, Jesper; Mattsson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    Objectives: Later weekday of surgery for oesophageal cancer seems to increase 5-year mortality, but the mechanisms are unclear. We hypothesised that early postoperative reoperations and mortality might explain this ...
  • On preoperative treatment selection and magnetic resonance imaging in rectal cancer 

    Hansson Elliot, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-20)
    In Sweden, 2000 patients are diagnosed with rectal cancer annually. Developments in surgery have improved survival and the addition of preoperative radiotherapy (RT) or chemoradiotherapy (CRT) has reduced local recurrence ...
  • Appetite control : genetic, immunological and neurobiological aspects 

    Lindfors, Charlotte (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-31)
    The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. The correct regulation of appetite is crucial, ...
  • Breast cancer in young women : aspects on mortality and local recurrence 

    Fredholm, Hanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-17)
    The general aim of the thesis was to gain increased insight into the long-term prognosis for young women with breast cancer. In a population-based cohort of 22,017 women with breast cancer, we studied prognosis by ...