Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 61-80 of 531
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Biomarkers and outcome in children with hypoxic ischemic encephalopathy
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-11-04)Approximately 1-6 per 1000 born infants will develop hypoxic-ischemic encephalopathy (HIE) with significant associated mortality and morbidity. For the past 45 years, severity of HIE has been stratified into mild, moderate, ... -
Leukocyte scintigraphy, SPECT/CT and PET/CT in prosthetic joint infection
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-22)Background: A known complication of arthroplasty is prosthetic joint infection (PJI). It can be challenging to diagnose and treat PJI due to the formation of a biofilm protecting the bacteria in chronic infections from the ... -
Orofacial function in children with speech sound disorders
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-21)Speech sound disorder (SSD) is one of the most common neurodevelopmental disorders in children and can have different aetiologies and outcome. Speech difficulties often co-exist with other disorders, such as motor difficulties ... -
Adult patients with severe-to-profound hearing impairment : a clinical, register-based, and interview study
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-20)In Sweden, roughly 25,000 individuals in the adult population have severe-to-profound hearing impairment, a prevalence rate of 0.2-0.3%. This patient group often needs extended audiological rehabilitation. The general aim ... -
Abdominal wall complications after urological surgery
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-18)Background: Abdominal wall complications such as incisional hernia, bulging, and pain are known complications of surgery in the abdominal cavity. Most previous studies have been conducted on general surgical procedures, ... -
Antisecretory factor in the perinatal period
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-01)Preterm birth is the major cause of neonatal morbidity and mortality. Human milk, especially mothers’ own milk, has many health benefits for infants, especially infants born preterm. The causes of preterm birth are not yet ... -
Cholestasis in infants at risk
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-09-03)Cholestasis is a condition when bile flow from the liver to the intestines is impaired. Unresolved, it may lead to liver transplantation or death. Overall, it affects 1 out of 2500 term infants, but is far more common in ... -
Optimizing treatment : tumor markers and sclerotherapy in head and neck lesions
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-05-06)Treatment of malignant and benign lesions in the head and neck area is challenging, due to complex anatomy and function. It is thus urgent to find ways to individualize treatment, in order to reduce side-effects, but with ... -
Chronic kidney disease : a clinical model of premature vascular aging
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. ... -
Mapping the immune landscape in solid tumors : implications for immunotherapy
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)Our cells are programmed with various safety mechanisms to avoid transformation into tumor cells. In case these fail, we have a guarding immune system ready to recognize and eliminate these cells. Despite these safety ... -
Complications due to acute rhinosinusitis in children
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-15)Background: There is a lack of population-based studies of complications to acute rhinosinusitis in children. Previous studies have demonstrated a possible effect of the conjugate pneumococcal vaccine (PCV) on hospital ... -
Insulin resistance in children and adolescents : mechanisms and clinical effects
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-15)Background: Insulin resistance is a condition in which insulin does not achieve appropriate response in different target tissues, it is associated with obesity and one of the main culprits in the development of type 2 ... -
Prostate cancer : population-based screening and markers for long-term clinical outcome
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-12)In 1988 and 1989 a large screening study for prostate cancer was launched in Stockholm, Sweden. At the time approximately 27 000 men between 55 and 70 years of age resided within a defined area of southern Stockholm. 2400 ... -
To cut or not to cut : the association between weight loss and cardiometabolic health in adolescents and adults after Roux-en-Y gastric bypass
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-31)Energy cannot be destroyed, and in humans excess energy is stored as fat in adipose tissue. Accumulation of fat is thus the result of a positive energy balance, and obesity is defined as an excess amount of adipose tissue. ... -
Nutritional status and dysphagia in patients with oesophageal cancer : the impact of oncological and surgical treatment
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-18)The most common symptom of oesophageal cancer is difficulty swallowing, dysphagia, due to the tumour obstructing the oesophageal lumen often resulting in weight loss. In patients diagnosed with oesophageal cancer malnutrition ... -
Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)Background: Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30– 70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine ... -
Early vascular ageing and cellular senescence in chronic kidney disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular dis- ease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process ... -
Circulating proteins as predictors of cardiovascular mortality in endstage renal disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-24)Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Neurophysiological conditions for hearing in children using hearing aids or cochlear implants : an intervention and follow-up study
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-19)OBJECTIVES: The four studies in this thesis examine the central auditory pathways in children with hearing loss (HL) through recording event-related potentials (ERP) and mismatch negativity (MMN). The design of the project ...