Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 281-300 of 531
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Intrathecal adenosine for treatment of acute pain : safety assessments and evaluation in experimental, surgical and labour pain
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-11-21)Adenosine is an endogenous compound present in all cells in the body with a wide range of physiological effects. Exogenous administration of adenosine is used clinically as an antiarrytmic agent and as a vasodilator. In ... -
On the clinical value of genetic analysis in colorectal cancer patients
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-11-14)In Sweden, the incidence of colorectal cancer (CRC) is about 5000 new cases every year and this number has not changed markedly during the past twenty years. 90-95% of all CRC appear spontaneously, but there are also ... -
Monitoring and prevention of ischaemia-reperfusion injury in liver transplantation : experimental and clinical studies
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-11-07)Liver function after transplantation is determined not only by the quality of the donor organ or recipient related factors, but also by factors associated with organ preservation. During preservation, the liver graft is ... -
On loosening and revision in total hip arthroplasty
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-10-10)Periprosthetic bone resorbtion (osteolysis) and aseptic loosening constitute the major long-term complication in total hip arthroplasty. It has been suggested that osteolysis is the result of the action of osteoclasts ... -
Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2003-10-03)Aim: To study the natural history of Human Papillomavirus (HPV) infection in the general population and among women with acquired immunosuppression as well as to evaluate possible uses of human papillomavirus testing in ... -
Studies of prognostic and functional outcomes in surgery for rectal cancer
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-09-26)The order of priorities in surgery for rectal cancer are firstly to achieve local control and cure from the disease, secondly to minimise perioperative discomfort and complications, and thirdly to obtain the best possible ... -
Insulin resistance in pancreatic cancer
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-05-16)The dismal prognosis of pancreatic cancer (PC) is related to metabolic complications of the tumor. Impaired glucose tolerance or diabetes due to insulin resistance, and cachexia are observed early and frequently in these ... -
Effects of perioperative nutrition on insulin action in postoperative metabolism
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-04-25)Surgical operations are a fundamental part of contemporary treatment of disease. For example, 43 % of in-patients in Sweden undergo a surgical operation. Surgery is not yet without significant risks. Infectious complication ... -
Allogeneic stem cell transplantation in children : identification and prevention of complications : adoptive transfer of EBV-immunity
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2003-01-24)Allogeneic stem cell transplantation (SCT) can cure leukaemia, aplastic anaemia, and some inborn errors of metabolism and immunodeficiencies in children. As only 113 of patients who need SCT have an HLA-identical sibling, ... -
Surgery and recurrence in Crohn’s disease
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2002-01-11)Previous studies on risk factors for resection and postoperative recurrence in Crohn's disease (CD) have given inconclusive results. The aim of this study is to assess the probability of resection and recurrence in the ... -
Smoking cessation during pregnancy
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-11-02)Smoking habits, attitudes to smoking, and sources of information were monitored at three antenatal clinics (ANC) in suburban Stockholm, Sweden, during 1987-88. A questionnaire was mailed to pregnant women and their partners ... -
Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-05-25)Uterine fibroids, or leiomyomas, are the most common benign tumors in the female genital tract.They represent a major cause of gynaecologic morbidity. The etiology of these tumors is largely unknown but the levels of ... -
Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-05-25)Uterine fibroids, or leiomyomas, are the most common benign tumors in the female genital tract.They represent a major cause of gynaecologic morbidity. The etiology of these tumors is largely unknown but the levels of ... -
Intracellular free amino acids and nutritional status in children with chronic renal failure on different treatments
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-05-21)In untreated adult patients with chronic renal failure (CRF), and in chronic ambulatory peritoneal dialysis (CAPD) and kidney-transplanted patients, typical plasma and muscle intracellular amino acid (AA) patterns have ... -
Studies on the regulation and in vitro metabolic effects of leptin in children and adults
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-04-27)Leptin is a protein hormone secreted by adipocytes, which binds to receptors in the brain to affect food intake and energy expenditure. The leptin receptor is a member of the cytokine receptor family and is widely distributed ... -
The femoral component in total hip arthroplasty : results of uncemented and cemented fixation
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2001-04-05)There is no general agreement on whether hip prostheses should be implanted with or without cement. In Sweden over 90% of primary hip replacements are performed with the use of cement while in other countries uncemented ... -
Congenital adrenal hyperplasia, CYP21 deficiency, screening and clinical aspects
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-03-30)Congenital adrenal hyperplasia (CAH) is a group of recessively inherited disorders. More than 90% of all cases of CAB are caused by 21-hydroxylase deficiency. This enzyme deficiency results in reduced ability to synthesize ... -
Bacterial colonisation and infection of the lower airways in cystic fibrosis : a microbiological and clinical study
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-03-02)Pulmonary deterioration has remained the major cause of mortality in cystic fibrosis (C17) patients despite the considerable improvement of their survival due to more efficient therapy and centralised care. The progression ... -
Insulin action and secretion after surgical trauma : an experimental study in the rat
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2001-02-22)Physical injury or surgical trauma leads to an endocrine-metabolic response that causes a catabolic state designed to promote the healing process. Insulin resistance and mobilization of endogenous fuel stores are prominent ... -
Semantic analysis of irrelevant speech in dementia
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2001-01-19)This thesis demanded for studies within an interface between semantics, interaction and neuropsychology. The topic for the thesis was irrelevant discourse caused by dementia and foremost so called confabulation. Systematic ...