Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 261-280 of 531
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Endometrial, embryonic and ovarian aspects of human implantation
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-05-11)The general aim of the studies was to add more understanding to the mechanism of human embryo implantation, which will allow us to improve pregnancy rates in assisted reproduction. The simultaneous positive spatial ... -
Glutathione during stress in man
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-05-12)Glutathione, a tripeptide (gamma-glutamyl, -cysteinyl, -glycine), is quantitatively the most important antioxidant in man, protecting cells from the toxic effects of reactive oxygen species (ROS). These highly reactive ... -
Synovial metabolism after knee joint arthroscopy : a microdialysis study
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-03-03)Postoperative pain and swelling of the knee is a general finding after arthroscopy. In order to optimize and individualize the treatment it is of great importance to increase basic knowledge of perioperative local biochemical ... -
Liver transplantation and the role of adjuvant therapy for advanced primary liver tumours
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2005-11-11)Liver transplantation (LT) for unresectable locally advanced primary liver tumours (aPLT) is associated with an inferior survival compared to other established indications. As organ shortage in most regions is the major ... -
Human experimental pain models : methodological and analgesic studies
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2005-05-13)Pain is an important clinical issue with great impact on society and individuals' well being. It is well established that sensory abnormalities induced by tissue trauma and inflammation are clinically important in various ... -
Amino acid and protein turnover in human skeletal muscle
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2005-03-25)Critically ill patients are characterised by a severe net protein catabolism. The rate of muscle protein loss is in the magnitude of 10% per week. A consequence of muscle wasting is increased weakness, which is associated ... -
Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-11-26)The mechanism behind the vascular adaptation during pregnancy is poorly understood. The fall in peripheral resistance, particularly in the uterine vasculature, is crucial for sufficient increase in uteroplacental blood ... -
Immune reconstitution after allogeneic hematopoietic stem cell transplantation
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-11-05)After treatment with allogeneic hernatopoietic stem cell transplantation (HSCT) the patient suffers from a deficient immune system for at least 12 months or longer. During this period, the patient is susceptible to infections ... -
Estrogen effects on different neurotransmitters in rat hippocampus : implications for cognitive function
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-11-12)The past decade has witnessed a growing interest in estrogens and their activity in the central nervous system, which extends beyond the reproductive functions. Estrogen is known to interact with different neurotransmitter ... -
Dynamic magnetic resonance imaging of the breast : imaging features for diagnosis and prognosis of breast cancer
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-10-29)The general aim of the present thesis was to identify and study dynamic contrast-enhanced magnetic resonance imaging (CE-MRI) features that contribute to the diagnosis and may help in predicting prognosis in breast ... -
Nutritional and functional effects of energy-dense food in the frail elderly
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-10-01)Eating and nutritional problems are common in frail elderly individuals receiving care in municipalities and hospitals. The overall aim of the present thesis was to evaluate the effects of serving additional energy to frail ... -
Foregut motility disorders : a clinical and experimental study
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-08-13)Objective: To investigate some clinical aspects and treatment modalities of foregut motility disorders and to experimentally explore some mechanisms involved. Special emphasis has been put on elucidating and evaluating ... -
Atherosclerosis of the ascending aorta as a risk factor for stroke after cardiac surgery : a study based on epiaortic ultrasound
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-04-23)Postoperative stroke is a dreaded problem in cardiac surgery and atherosclerosis of the ascending aorta (AAA) is an important risk factor. The risk from calcified AAA, the extent and the topography of the disease in the ... -
Human ovarian follicle recruitment : an in vitro approach
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-03-17)Following the first reports of successful cryopreservation of human ovarian tissue, the freezing and banking of such tissue has become common practice worldwide for the preservation of fertility. Patients include those ... -
Molecular aspects of glutathione synthetase deficiency
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-02-27)The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in ... -
Matrix metalloproteinases and their inhibitors in ocular neovascularization
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-01-30)Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part ... -
Haemodynamic and ventilatory effects of laparoscopic surgery
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2004-01-23)Background: It has been shown repeatedly that the establishment of pneumoperitoneum (PP) is associated with increased cardiac filling pressures, as well as increased blood pressure and systemic vascular resistance. Patients ... -
Exposure to birch pollen and development of atopic disease in childhood
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-01-23)Background: In 1993 extremely high levels of birch pollen were recorded in Stockholm, Sweden. This provided an opportunity to evaluate the effects of aeroallergen exposure on the early immune response. Objective To assess ... -
Clinical, histopathologic and genetic diagnosis in osteogenesis imperfecta and dentinogenesis imperfecta
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-01-23)The aims of this thesis were to investigate (1) dental aberrations in a large sample of unrelated patients with different types and forms of OI, (2) degree of dentin dysplasia in relation to type and form of OI and clinical, ... -
Experimental studies on endotoxin infusion in human : evaluation of pharmacological immunomodulation by adenosine and nicotinamide
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2003-11-14)Introduction: Septicaemia and the systemic inflammatory response syndrome (SIRS), is a major cause of mortality among patients in the intensive care units. Inflammation and thrombosis involve multicellular phenomena with ...