Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 241-260 of 531
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Isolated islets of Langerhans trigger an instant blood mediated inflammatory reaction : a finding with implications for intraportal islet transplantation
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2000-04-14)Islet transplantation offers a logical means to treat insulin-dependent diabetes. However, for reasons poorly understood, the clinical results with islet transplantation have been vastly inferior to those obtained with ... -
Rhinostereometry and laser doppler flowmetry : simultaneous measurements of inflammation and steroid effects in normal and allergic human nasal mucosa
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2000-02-18)This thesis describes the development of a combination of non-invasive methods for measuring different aspects of inflammation simultaneously in a selected part of the human nasal mucosa. It also describes use of this ... -
Isthmic spondylolisthesis in adults : a randomized controlled trial
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1999-11-19)Isthmic spondylolisthesis, i.e. the slipping of one vertebra on another due to a defect in the pars interarticularis, is a common radiological finding in the general population and can sometimes be the source of chronic ... -
Modulation of the inflammatory response in experimental bacterial meningitis
(Institutionen för immunologi, mikrobiologi, patologi och infektionssjukdomar / Department of Immunology, Microbiology, Pathology and Infectious Diseases, 1999-11-19)In bacterial meningitis, tissue damage in the central nervous system (CNS) is inflicted by the host's inflammatory response to invading pathogens, rather than by the bacteria itself. Adjuvant treatment with anti-inflammatory ... -
Regional ventilation, pulmonary perfusion and gas exchange in supine and prone positions
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1999-10-29)The rationale for treating patients with acute lung injury in the prone position springs from a number of observations. Clinical reports have documented improved oxygenation when patients are turned prone. Regional vascular ... -
Neuromuscular effects related to hind limb disuse : experimental studies in the rat
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1999-10-08)Disuse is known to cause skeletal muscle atrophy and a dramatic increase in bone resorption. In this work the effects of disuse were studied in rats after hind limb immobilization for 5 days, 2 weeks, 4 weeks, and 8 weeks. ... -
Hyperlipidaemia : an evaluation of management and attitudes among doctors and knowledge and attitudes in the population
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1999-09-10)An evaluation of management and attitudes among doctors and knowledge and attitudes in the population Coronary heart disease (CHD) is the main cause of death in the western world, and hyperlipidaemia is one of the major ... -
Experimental implant-associated orthopaedic infections
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1999-05-21)Although indispensable in today's medicine, orthopaedic implants may also cause adverse reactions. A foreign body increases the local susceptibility to colonisation by microorganisms, and hence the risk of infections. These ... -
Cataract surgery in patients with diabetes mellitus : clinical studies
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1999-05-14)The aim was to evaluate phacoemulsification cataract extraction with small incision and implantation of heparin-coated intraocular lens (IOL) in the capsular bag in patients with diabetes mellitus (DM). The aqueous ... -
Mucosal regeneration following sinus surgery : an experimental study and clinical study
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1999-02-26)The investigations described in this thesis concerned functional and structural aspects of the regenerated sinus mucosa following sinus surgery. In a biopsy material collected pre- and postoperatively from patients ... -
Back pain in primary care : aspects on treatment and the possible influence of oral contraceptives
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1999-01-08)The general objectives of this thesis were to investigate back pain in a primary-care setting, and especially to study the effect of manual treatment on pelvic-joint dysfunction, the effect of sterile-water injections on ... -
Endocrine and therapeutic aspects of infertile women with the polycystic ovary syndrome
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1998-11-13)Fertility treatment with gonadotrophins in infertile clomiphene resistant women with the polycystic ovary syndrome (PCOS) is troublesome with an unpredictive ovarian response. The purpose of this study was to elucidate ... -
Insulin treatment of elderly type 2 diabetic patients
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1998-11-13)In this study, the effect of improved metabolic control through insulin treatment was investigated in elderly patients with type 2 diabetes with secondary failure of oral treatment. Forty, consecutive, elderly ... -
Neuropeptides in bone and joint tissues : alteration in adjuvant arthitis
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1998-11-13)In this thesis, the localization, distribution and quantification of met-enkephalin (Met-enk), neurokinin-A and somatostatin in normal bone and joint tissues of the rat have been studied. Moreover, concentration alterations ... -
Liver protein metabolism in man
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1998-11-06)Protein depletion is a determinant of clinical outcome in catabolic states. Consequently studies of protein metabolism are necessary to understand the underlying mechanisms. Since the regulation of the synthesis and breakdown ... -
Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 1998-10-30)Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In ... -
Glutathione metabolism of human skeletal muscle in surgical trauma
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 1997-03-14)Glutathione Metabolism of Human Skeletal Muscle in Surgical Trauma Jia-Li Luo Dissertation from the Department of Anesthesiology and Intensive Care, Huddinge University Hospital, KARO Institution, Karolinska Institutet. ... -
Gender-related small artery function : implications for estrogenic compounds
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-11-17)Background: Vascular effects of estrogens have been shown to be mediated by estrogen receptor (ER)α. The discovery of ERβ, which shares many similarities with ERα, brought about a reevaluation of the role of the ER subtypes ... -
Diastolic heart function in hypertension-induced left ventricular hypertrophy
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-09-15)Hypertensive left ventricular (LV) hypertrophy is an independent strong risk factor for cardiovascular morbidity and mortality. An abnormal diastolic relaxation in the absence of systolic impairment is often seen in patients ... -
Laparoscopic and open surgery for colon cancer : studies on costs and health related quality of life
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-05-19)Colon cancer is one of the most common forms of cancer in the Western world, and the basis for treatment is surgery. Laparoscopic colon resection (LCR) has been developed since the early 1990s. Short- and longterm outcomes ...