Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 221-240 of 531
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An observational study on the outcome after surgery for lumbar disc herniation in adolescents compared to adults based on the Swedish Spine Register
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-05)BACKGROUND CONTEXT: Disc-related sciatica has a prevalence of about 2% in adults, but is rare in adolescents. If conservative treatment is unsuccessful, surgery is an option. PURPOSE: The aim of this study was to ... -
Modeling human germ cell development with pluripotent stem cells and characterizing the putative oogonial stem cells
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-05-19)The current understanding of human germ cell development is limited and is at most parts extrapolated from studies of mice or other model organisms. Particularly, the specification events of human germ cell lineage are ... -
Hepatocyte transplantation : experimental and clinical studies
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-05-13)Hepatocyte transplantation is an experimental treatment for patients with end-stage liver disease and inborn metabolic liver disorders. Studies in animal models and human trials have shown that allogenic hepatocytes infused ... -
The next level : video gaming, cognition and motivation in surgical simulator training
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-05-08)Image guided surgery uses small incisions or existing entry ports of the body in order to decrease surgical trauma which will hopefully lead to less infections, complications and number of days needed in the hospital. ... -
Magnetic resonance imaging in the evaluation of chronic Achilles tendinosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-05-06)The aim of the thesis was to evaluate magnetic resonance imaging (MRI) as an outcome in the evaluation of treatment in mid-portion Achilles tendinosis. Conventional MRI sequences, dynamic contrast enhanced MRI and measurement ... -
Pancreatic ductal adenocarcinoma : computed tomography for diagnosis, local staging and prediction of postoperative complications
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-30)Pancreatic ductal adenocarcinoma (PDAC) is a disease with a dismal prognosis, being the 4th leading cause of cancer deaths in Sweden and worldwide. The only potentially curative therapy is surgery. Unfortunately, by the ... -
The expression of the structural proteins dendrin, Plekhh2 and Neph1 in the glomerular filtration barrier
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-29)Background: The podocytes are injured in many acquired glomerular diseases. This may present as proteinuria or morphological changes such as foot process effacement (FPE) or loss of podocytes in the urine. The exact ... -
Inheritance and genetics in idiopathic scoliosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-29)Idiopathic scoliosis is the most common spine deformity, affecting approximately 3% of children and adolescents. Its aetiology is still unknown. However, relatives of individuals with idiopathic scoliosis have a higher ... -
Studies on hip fracture patients : effects of nutrition and rehabilitation
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-20)Hip fracture in the elderly is a serious condition associated with increased mortality. Survivors experience an increase in morbidity and disability that affect their independence and quality of life; the outcome for ... -
Self and other : socio-emotional aspects of development in children with language impairment
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-17)The thesis comprises four studies that focus on young children with language impairment (LI). The research focus was different aspects of socio-emotional development. In Study I visual check back behaviors were ... -
Pain relief following cesarean section : short and long term perspectives
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-04-17)Background: Postoperative pain treatment in women undergoing cesarean section (CS) needs to be effective to enable fast and smooth recovery without adverse outcomes and to improve breastfeeding and bonding between mother ... -
Vascular and inflammatory markers in chronic kidney disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-03-27)In patients with chronic kidney disease (CKD), inflammation and malnutrition are harmful and highly prevalent conditions with influence on the atherosclerotic process and outcome. The risk of cardiovascular disease (CVD) ... -
Human papillomavirus and cervical cancer : detection of potential markers of disease progression using liquid-based cytology
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-03-27)This protect aims to evaluate alternative strategies to screen for cervical cancer including liquid-based cytology (LBC) with supplementary reflex testing for human papillomavirus (HPV), p16INK4a, HPV-L1 capsid protein, ... -
Pharmacokinetics and inner ear transport of cisplatin
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-02-25)Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible hearing loss. The ototoxic mechanisms of cisplatin ... -
Intravenous contrast media optimization at computed tomography
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-02-19)The administration of intravenous contrast media (IV CM) is essential for detecting lesions at most computed tomography (CT) examinations. The overall aim of this thesis is to investigate different aspects of IV CM ... -
Clinical and molecular studies in ANCA associated vasculitis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2014-12-19)ANCA associated vasculitis (AAV) is a heterogeneous group of diseases characterised by sterile pauci-immune systemic small vessel inflammation and closely associated with the presence of anti-neutrophil cytoplasmatic ... -
Quinine as a model for the study of cochlear hearing loss in humans
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2000-08-18)Quinine has been used for centuries and is still recommended for the treatment of severe falciparum malaria and non-severe chloroquine-resistant malaria. Among its side effects is the concentration-dependent and reversible ... -
Prognostic and epidemiological factors in childhood leukemia : studies of p53 and MDM2 expression and of space-time clustering
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2000-05-05)Although cure rates in acute childhood leukaemias have improved it remains a challenge to understand how molecular aberrations influence the prognosis of leukaemia and thus the choice of optimal therapy. Some studies have ... -
Early diagnosis of diabetic retinopathy by mass examinations in primary health care
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2000-05-09)The general objective of this thesis was to describe a system for fundus photography for early diagnosis of diabetic retinopathy, performed by mobile teams visiting primary health care centres in Stockholm County. Large-scale ... -
Immunological and inflammatory mechanisms in ocular allergy with special reference to vernal keratoconjunctivitis : clinical and experimental studies
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2000-05-19)Ocular allergy encompasses a wide range of conditions, most of which implicate IgE in the pathogenesis. In contrast to the benign nature of seasonal allergic conjunctivitis (SAC), the less common chronic eye diseases vernal ...