Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions

Now showing items 201-220 of 531

    • Aspects of neoadjuvant therapy in the curative treatment of cancer in the esophagus or gastroesophageal junction 

      Klevebro, Fredrik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-06-09)
      Malignant esophageal tumors are among the most severe cancers. Only about 30% of the patients are suitable for curative treatment at diagnosis. The treatment is extremely demanding and unfortunately has disappointing ...

    • Focal knee resurfacing : a translational study in sheep on the treatment of focal condylar cartilage lesions with metal implants 

      Martinez-Carranza, Nicolas (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-04-29)
      Background: The translational process of introducing a new treatment concept in medicine from innovation to clinical application is a challenging endeavour that often involves animal experiments. Focal cartilage lesion ...

    • Markers of inflammation and cardiovascular disease in dialysis patients : variability and prognostic value 

      Snaedal, Sunna (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-04-15)
      Patients with end-stage renal disease are burdened with a high cardiovascular morbidity and mortality. Inflammation is a common feature in these patients and strongly associates with cardiovascular complications and outcome. ...

    • Cardiopulmonary adaption to one-lung ventilation and neoadjuvant therapy during treatment of esophageal cancer 

      Lund, Mikael (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-04-13)
      Introduction: Esophagectomy is the main form of curative treatment for esophageal cancer and has a high morbidity rate. Neoadjuvant chemo- (CT) or chemoradiotherapy (CRT) is employed to increase long-term survival. To ...

    • Early cardiovascular risk markers and cardiac function in children with chronic kidney disease 

      Tranæus Lindblad, Ylva (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-04-08)
      Children with advanced chronic kidney disease (CKD) have an increased risk of premature death, foremost due to cardiovascular disease (CVD). The cardiovascular (CV) morbidity starts early in the disease process and renal ...

    • Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach 

      Honeth, Louise (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-04-08)
      Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are spread all over the country and come from all socioeconomic groups. Recreational fiearms can produce peak noise levels between 156-164 ...

    • Nicotine and endotoxin in airway hyperreactivity and inflammation 

      Xu, Yuan (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-02-25)
      Active, as well as passive cigarette smoke exposure is detrimental to the human health, negatively affecting the cardiovascular, respiratory and immune systems. In addition, it is also carcinogenic. The present thesis ...

    • Fetal exposure to neurotropic drugs : neonatal effects and long-term outcome 

      Forsberg, Lisa (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-02-05)
      Chronic illness in pregnant women is common. In epilepsy, bipolar disorder (BD) or major depressive disorder (MDD), pharmacotherapy is often necessary. Some neurotropic drugs may have negative effects on children exposed ...

    • Elevated fasting glucose levels in obese children and adolescents : prevalence and long-term consequences 

      Hagman, Emilia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-01-29)
      Background: Obesity in childhood and adolescents is a major concern in Sweden, as in many parts of the world. Already during the pediatric years is obesity associated with several metabolic complications, which often ...

    • Cellular correlates of sensory processing in the mammalian audio-vestibular brainstem 

      Leijon, Sara (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-01-25)
      Efferent projections to the vestibular inner ear organs have remained elusive. To shed light on their physiological role, a first investigation of the vestibular efferent (VE) neurons in the brainstem was undertaken by ...

    • Coronary computed tomography in patients with myocardial infarction and non-obstructed coronary arteries 

      Bacsovics Brolin, Elin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-11-20)
      Cardiovascular disease (CVD) is the number one cause of death worldwide. In Sweden, almost 30 000 people suffer an acute myocardial infarction (AMI) each year and, despite the greatly improved survival after AMI, CVD ...

    • Bilateral cochlear implants in children : clinical and methodological studies 

      Asp, Filip (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-11-16)
      A cochlear implant (CI) restores functional hearing in individuals with bilateral severe- to-profound sensorineural hearing loss. Despite hearing loss in both ears, CIs are usually provided unilaterally, excluding the ...

    • Anaemia, blood loss and colorectal cancer 

      Mörner, Malin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-11-02)
      Introduction: Colorectal cancer (CRC) is the fourth most common cancer worldwide and strikes both sexes. The age-adjusted 5-year survival in Sweden was 60% in the early 21 st century. Approximately 50% of patients are ...

    • A tiny glimpse into the human brain using model-free analysis for resting-state fMRI data 

      Wang, Yanlu (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-10-23)
      Resting-state functional Magnetic Resonance Imaging (fMRI) acquires four dimensional data that indirectly depicts human brain activity. Within these four dimensional datasets reside resting-state functional connectivity ...

    • Cardiovascular development of the preterm infant 

      Schubert, Ulf (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2016-09-16)
      The numbers of preterm births and cardiovascular deaths are increasing in most countries. The causes of both developments are multiple and apparently not related to each other. However, preterm birth might provide an ...

    • Physical activity in Swedish and Chinese young children and their parents 

      Johansson, Elin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-09-24)
      Physical activity is believed to affect health, already in childhood. Studies of physical activity in children under the age of three are, however, sparse. The overall aim of this thesis was to explore physical activity ...

    • Shining a light on organ donation after death : on various aspects influencing organ donation 

      Gyllström Krekula, Linda (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-09-07)
      Introduction: The willingness to donate organs after death is widespread in our country, Sweden. Nevertheless, the donation rate is rather low and patients still die while waiting for an organ. One of the obstacles to organ ...

    • Smoking, smoking cessation and fracture risk in elderly women followed for 10 years 

      Thorin, Mats H; Wihlborg, Axel; Åkesson, Kristina; Gerdhem, Paul (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-09-07)
      Summary: This study examines the impact of smoking and smoking cessation on fracture risk in 75-year-old women followed for 10 years. Smoking increased fracture risk, especially for vertebral fractures. Smoking cessation ...

    • Neuroradiological aspects of multiple sclerosis : from early signs to late disease stages 

      Granberg, Tobias (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-10)
      Background: Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system and a leading cause of neurological disability in young adults. Magnetic resonance imaging (MRI) has ...

    • Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis 

      Grauers, Anna; Wang, Jingwen; Einarsdottir, Elisabet; Simony, Ane; Danielsson, Aina; Åkesson, Kristina; Ohlin, Acke; Halldin, Klas; Grabowski, Pawel; Tenne, Max; Laivuori, Hanne; Dahlman, Ingrid; Andersson, Mikkel; Bach Christensen, Steen; Karlsson, Magnus K; Jiao, Hong; Kere, Juha; Gerdhem, Paul (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-05)
      Background: Idiopathic scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide ...