Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 261-280 of 330
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Nutritional status, body composition and diet in patients with rheumatoid arthritis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-03-13)Rheumatoid arthritis (RA) is a chronic inflammatory disease with higher mortality rate than in the general population, which is largely attributed to cardiovascular disease (CVD). Another consequence of the inflammatory ... -
The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-11-18)Cell and gene therapy of cancers has received much attention in the past decade. A number of applications of cancer treatment have been developed and used. One of the recent applications is immunotherapy of tumours with ... -
Biological pathways in B-cell non-Hodgkin's lymphoma
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-11-20)Non-Hodgkin’s lymphomas have become more prevalent in the past 20 years. They constitute a diverse group of lymphoid tumors that have been understood and classified according to their clinical behaviour, anatomic location, ... -
Pathogenetic mechanisms in irritable bowel syndrome
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-09-21)Aims of the thesis: To study new pathogenetic mechanisms in IBS; to find out if IBS is a neuromuscular disease affecting the small bowel; to study humoral factors in gut dysmotility associated with visceral neuropathy; ... -
Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-09-23)Increased apoptosis of hematopoietic progenitor cells is a hallmark for the myelodysplastic syndromes (MDS), and one of the main reasons for the ineffective hematopoiesis and subsequent cytopenia characteristic for ... -
Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2010-09-24)Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pKa and a high reactivity with many electrophilic ... -
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-05-28)Coxsackievirus group B (CVB) is a common virus that usually causes only mild symptoms in humans. However, occasionally these infections result in severe diseases like meningitis, myocarditis and pancreatitis. In addition, ... -
Immune evasion and dissemination of Toxoplasma gondii
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-08-24)Toxoplasma gondii is an obligate intracellular protozoan parasite which propagates in a complex life cycle where infection of Felidae family-members (Cats) results in sexual recombination whereas all other warm-blooded ... -
Triggering and mechanisms of natural killer cell mediated cytotoxicity
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-08-01)Natural killer (NK) cells are innate immune cells that contribute to defense against infected and transformed cells by target cell killing and cytokine release. In addition, data suggest that NK cells contribute to immune ... -
Atopic dermatitis : aspects of defence defects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-04-24)Atopic dermatitis (AD) is an inflammatory skin disease, typically with a chronic relapsing course and a defective skin barrier function. Recently, mutations of the skin barrier gene encoding filaggrin have been reported in ... -
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-02-24)The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A ... -
Myocardial gene therapy and gene expression in angina pectoris
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-03-31)Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, ... -
Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-11-18)Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within ... -
Somatostatin, dendritic cells and peptide T in psoriasis : a clinical, immunohistochemical and functional study
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-10-13)Peptide T is an octapeptide designed to block the CD4 receptor. In a phase 1 study 9 psoriasis patients were treated with 2 mg peptide T i.v. once daily for 28 days and followed for a further 3 months. Five patients improved ... -
Clinical aspects of Mycoplasma genitalium infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-01-15)The microorganism Mycoplasma (M.) genitalium was first isolated by culture in 1980. Further attempts to culture this mycoplasma were difficult because of its slow growing nature. The development of polymerase chain reaction ... -
Body composition and bone mineral density in rheumatoid arthritis : influence of inflammation and treatment with glucocorticoids and TNF-blocking agents
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-11-20)Rheumatoid arthritis (RA) is a chronic inflammatory disease. Besides symptoms from the joints, changes in body composition and reduced bone mineral are common. Increased fat mass (FM) and loss of muscle mass contribute to ... -
NK cell and dendritic cell interactions in innate immune responses
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-04-24)Natural killer (NK) cells are cytotoxic cells of the innate immune system. They have been found to be critical in the defense against infections and also against some tumors. Recent studies have shown that NK cells ... -
Aspects of nursing care for patients with head and neck cancer receiving radiation therapy
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-12-30)Head & Neck (H&N) cancer accounts for approximately 3 % of all cancer in Sweden. The treatment options include radiotherapy (RT), surgery and/or chemotherapy. Both the disease and the treatment cause side effects that often ... -
Erythropoietic protoporphyria clinical and epidemiological aspects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-02-26)Erythropoietic protoporphyria, EPP, is an inherited disease in which the main clinical manifestations are painful cutaneous sensitivity to intense light and liver disease which in some requires liver transplantation for ... -
Cardiac electrophysiologic effects of mental stress
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-02-13)Background: Mental stress may trigger serious arrhythmias. Mental stress tests cause significant increases in heart rate, blood pressure and cardiac output. When beta-adrenergic inhibition is considered for secondary ...