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Recent submissions

  • Genetic predisposition to immune cell malfunction and inflammation 

    Torralba-Raga, Lamberto J. (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
    Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds ...
  • The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination 

    Widgren, Katarina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
    Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ...
  • Studies of inflammatory responses in hantavirus infection 

    Maleki, Kimia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)
    Throughout the world, orthohantaviruses cause severe, acute infections in humans. Orthohantaviruses, commonly referred to as hantaviruses, are zoonotic viruses with a single stranded RNA genome of negative sense. Hantavirus ...
  • From fatty liver to end-stage liver disease through type 2 diabetes 

    Björkström, Karl (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)
    The past decades have seen a marked increase in the incidence of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Epidemiological studies have clearly demonstrated that there is an association between type 2 ...
  • Clinical consequences of pancreatic exocrine insufficiency 

    Hedström, Aleksandra (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-27)
    Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine ...
  • The antimicrobial role of human MAIT cells 

    Boulouis, Caroline (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-19)
    MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. ...
  • Strategies to assess and improve prognostication of plasma cell disorders 

    Gran, Charlotte (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-01)
    Plasma cell dyscrasias (PCD) are a group of disorders, most of which have the overproduction of monoclonal immunoglobulins (M-protein) in common. Included in the group of PCDs are both benign and treatment demanding ...
  • Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity 

    Mily, Akhirunnesa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)
    Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ...
  • Innate lymphoid cell plasticity and heterogeneity in human tissues 

    Mazzurana, Luca (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-05)
    The human immune system is a vital mechanism that protects the host from outside threats. The two main branches of this system, consisting of innate and adaptive immunity, aid the host when dangers of both imminent and ...
  • Platelet transfusions in hematological disorders 

    Karlström, Cecilia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-01-12)
    Platelets are important for clot formation and vascular integrity. Thrombocytopenic patients with hematological disorders are at risk of bleeding and platelet transfusions are important in supportive care and treatment of ...
  • Chronic bone marrow failure and transfusion patterns : epidemiological studies of blood transfusions and outcomes in patients with myelodysplastic syndromes 

    Rydén, Jenny (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-12-22)
    Myelodysplastic syndromes (MDS) encompass a diverse group of clonal hematological malignancies characterized by dysplasia and ineffective hematopoiesis with an increased risk of leukemic evolution. It is a disease of the ...
  • Mesenchymal niche contribution to normal and malignant hematopoiesis 

    Sandhow, Lakshmi (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-11-05)
    Normal hematopoiesis is tightly regulated by hematopoietic microenvironment/niche in bone marrow (BM) via direct hematopoietic cell-niche cell interaction and factors secreted by various types of cellular niches. The BM ...
  • Human innate lymphocytes in host defense, tissue function and reproduction 

    Strunz, Benedikt (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-23)
    The immune system is present in all tissues of the human body. In order to respond appropriately to infections, cells of the innate and adaptive immune system work in concert. In this thesis, we focused on natural killer ...
  • Viral gastrointestinal infections in allogeneic hematopoietic stem cell transplant patients 

    Swartling, Lisa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-16)
    Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since ...
  • Assessment and prognostic importance of nutritional status and body composition in liver transplantation 

    Lindqvist, Catarina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-09-08)
    Chronic liver disease and liver cirrhosis are progressive diseases closely linked to metabolism and nutritional status. Weight loss is a result of negative energy balance and is therefore a good measure of risk of malnutrition. ...
  • Models of the lung tissue microenvironment for studies of human myeloid cell function 

    Chen, Puran (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)
    Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment ...
  • Interleukin 15 throughout murine natural killer cell biology 

    Luu, Thuy Thanh (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)
    Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate ...
  • Innate-like T cells in the immunopathogenesis of HIV-1 infection 

    Lal, Kerri Guth (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-20)
    The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy. ...
  • Shame and stigma in weight management during pregnancy and post bariatric surgery : perspectives of patients and healthcare providers 

    Christenson, Anne (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-20)
    Background: Body mass index (BMI) increases across the world, yet there is an alarming lack of obesity prevention and treatments that are effective, harmless and available for everyone in need. Stigmatizing attitudes ...
  • Hepatitis C : prevalence, risk factors and implications for screening 

    Millbourn, Charlotta (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-17)
    Hepatitis C is a blood-borne virus that mainly affects the liver. The infection is often contracted early in life and remains as an asymptomatic slowly progressive disease. The World Health Organization (WHO) has set a ...

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