Doktorsavhandlingar / Doctoral Theses - H7 (MedH)
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Recent submissions
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Immune cell-derived adipokines : role in white adipose tissue function and link to metabolic health
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-01-17)The white adipose tissue (WAT) is home to a vast array of immune cells that control local homeostasis and metabolism by engaging in intricate crosstalk with adipocytes and their precursors through secreted factors (adipokines). ... -
The role of liver myeloid cells in obesity and metabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-24)Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, ... -
Hereditary hypercholesterolemia and cardiovascular disease : functional and epidemiological aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-20)Background. Individuals with familial hypercholesterolemia (FH) and/or high levels of lipoprotein(a) [Lp(a)] are genetically predisposed to develop early cardiovascular disease (CVD). We aimed to study the subclinical and ... -
Phenotyping of severe asthma in a clinical context
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-17)Severe asthma is a chronic heterogeneous inflammatory disease characterized by several clinical phenotypes and molecular endotypes. Although it affects a relatively small proportion of the asthma population (approximately ... -
Regulation of cytotoxic lymphocyte effector functions
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-06)Studies of patients with inborn errors of immunity provide an important opportunity to understand the human immune system in a natural context. The articles in this thesis are a compilation of such investigations. With ... -
Cellular and molecular mechanisms in the pathogenesis of irritable bowel syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-23)Irritable bowel syndrome (IBS) is part of the functional bowel disorder spectrum with no single accepted theory of its development and no biological marker for diagnosis. Today the diagnosis is defined by the ROME criteria, ... -
Novel vaccines and antiviral treatments for enterovirus induced infections and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-16)Enterovirus infections are common around the world and can impact people’s lives in various ways, causing pancreatitis, myocarditis, common cold and more. This thesis is focused on testing the effectiveness of new vaccines ... -
Strategies to optimize natural killer cell functions in the tumor microenvironment
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-13)Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer ... -
Improving prognostication for patients with myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-25)Background and aims: MDS constitute a heterogenous group of myeloid malignancies mainly characterized by dysfunctional hematopoiesis. Although cytopenia, dysplastic features and evidence of clonality are essential criteria ... -
Redox and epigenetic modulators regulate cardiac function and remodeling in health and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-22)Oxidative species are a divergent group of cellular metabolites with a wide variety of functions. Together with reductants, they regulate almost all cellular functions, from mediating cellular communications to catalyzing ... -
Liver transplantation, cancer risk and comorbidity in acute porphyria
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-11)The porphyrias are a group of rare, mostly genetic, metabolic diseases caused by alterations in the eight enzymatic steps of the heme biosynthesis pathway. This thesis focuses on three of these diseases, acute intermittent ... -
Natural killer cell development and function in the context of allogenic stem cell transplantation and cell therapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-07-27)Natural killer (NK) cells play a crucial role in the control of viral infections and transformed, cancerous cells. These innate cells have high cytotoxic capacities and use a multitude of receptors to interact with ... -
Risk of hepatocellular carcinoma, liver-related complications, and death in persons living with chronic hepatitis B and D
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-07-21)Chronic hepatitis B virus (HBV) infection affects 257 million individuals and is a leading cause of liver-related morbidity and mortality. Hepatitis D virus (HDV) is a satellite virus, that needs HBV for packing and ... -
Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-25)Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival ... -
Cell shape determines gene expression in cardiomyocytes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-04)The fundamental biological processes involve sensing biophysical stress, strain and forces along with conversion of these stimuli into chemical signals. These processes are linked to the atrophic and hypertrophic responses. ... -
Improving NK cell-based immunotherapy of cancer by exploration of migration and inhibitory receptor-ligand interactions
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-03)The possibility to utilize the immune system as a mean to target malignantly transformed cells has emerged as a novel treatment modality during the last decades and is a field that is under rapid development. Natural ... -
Human innate lymphoid cell trafficking and function in vivo
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-04-14)Human organs and tissues, such as the lung, are composed of various spatially distinct anatomical compartments. Each compartment represents a different tissue environment within the organ, performs specific functions and ... -
Magnetic resonance imaging as a tool for diagnosis, evaluation, and prognosis in patients with primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-01-24)Primary sclerosing cholangitis (PSC) is a chronic liver and bile duct disease of unknown etiology. It usually progresses to liver failure and need for liver transplantation. Additionally, patients with PSC have an increased ... -
Understanding the heterogeneity of the hematopoietic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-11-25)The hematopoietic system is replenished and maintained throughout life by rare hematopoietic stem cells (HSCs) that reside in the bone marrow (BM) of adult mammals. Over the last 20 years, the advancement in the field lead ... -
Innate lymphocyte responses in inflammatory diseases
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-31)The immune system is a highly sophisticated system that has evolved to protect the host from external and internal threats. However, under some circumstances the immune response can get dysregulated and cause inflammatory ...