Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 241-260 of 330
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Structure and biological properties of scavenger receptor MARCO
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2002-09-06)Macrophages are monocyte-derived cells that play an important role in the innate immune response against invading pathogens. These cells express several host defense receptors that can be divided into two classes; those ... -
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-04-30)The aim of this thesis is to evaluate the influence of renal dysfunction on the presentation for myocardial infarction (MI), its treatment and outcome. Patients between 2003 and 2006 were selected from the nationwide Swedish ... -
Family history and breast cancer susceptibility : clinical and molecular studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-09-15)Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of ... -
Pathogenesis and immunotherapy of streptococcal septicemia and shock
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-10-03)Streptococei have been recognized as important causes of severe sepsis. Increased frequencies of streptococcal toxic shock syndrome caused by group A streptococcus (GAS) have been noted worldwide during the last 15 years. ... -
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-10-28)In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis ... -
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-04-29)Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ... -
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-03-26)Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and ... -
Studies on arterial endothelial function and intima-media thickness using ultrasound technique
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-05-09)Background: The development of ultrasonographic arterial imaging, high-resolution B-mode ultrasonography, has created a technical basis for a new diagnostic approach to atherosclerotic disease by offering the possibility ... -
Studies of specific immunity against viral infections in patients after stem cell transplantation
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-10-12)Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) experience a prolonged period of immune deficiency, resulting in significant morbidity and mortality from the infections. Viruses such as ... -
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-10-31)Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ... -
Immune evasion of human cytomegalovirus : studies of UL18 and US2 function
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-05-04)The β-herpes virus cytomegalovirus (HCMV) infects human populations at a high frequency worldwide. Primary infection with HCMV, usually asymptomatic, is followed by lifelong latency. During the long co-evolution of virus ... -
Modulation of invariant NKT cell activity by cytokines and receptors in human disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-08-27)Invariant natural killer T (NKT) cells are innate-like lymphocytes with both immunoregulatory and cytotoxic functions that play a role as activators and regulators of the immune response in many diseases. NKT cells are ... -
Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-11-27)Background: Therapeutic angiogenesis using i.e. VEGF and FGF have shown beneficial effects, however, delivery routes and other modulating agents have not been thoroughly investigated. In this study the efficacy of adenovirus ... -
p53 guardian of the genome and target for improved treatment of leukemia
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-03-02)P53 acts in several cellular processes as cell cycle checkpoints, DNA repair senescence and the surveillance of genomic integrity. Wt p53 inhibits cancer processes by causing cell cycle arrest and apoptosis. P53 is ... -
Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-03-05)Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant ... -
Physical activity in the severely obese : studies on measurement and promotion
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-03-26)Background: The amount and quality of evidence on how to effectively promote physical activity (PA) is low compared to what is known about the health effects of regular PA, especially in obese individuals. Aim : ... -
Neural crest in development and repair
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2007-10-19)This thesis is focused on several aspects of neural crest biology, largely related to two main issues: 1) understanding its mechanisms of migration and 2) analyzing the potential of neural crest stem cells or their derivatives ... -
Hidradenitis suppurativa : clinical studies with focus on evaluation
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-04-02)Hidradenitis suppurativa (HS) is a chronic inflammatory disease of mainly unknown aetiology which in most cases involves axillae or groins and that can last for decades. In this thesis different clinical aspects of HS ... -
Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2007-02-16)Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and ... -
Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2010-05-28)Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I ...