Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 281-300 of 330
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Studies of anemia in the myelodysplastic syndromes
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-08-15)Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). ... -
Evaluations of measurement techniques in functional dyspepsia : electrogastrography, satiety drinking test and 14C-urea breath test
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-08-20)The overall aim of this thesis was to evaluate the clinical usefulness of certain measurement techniques that may be helpful in the understanding of functional dyspepsia (FD). Electrogastrography (EGG) parameters were ... -
Therapeutic potential of natural killer cells in multiple myeloma
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-11-03)Multiple Myeloma (MM) is an incurable plasma cell neoplasm with a median length of survival after diagnosis of approximately three years; therefore new treatment modalities to eradicate the disease are needed. Although the ... -
Infectious endocarditis, aspects on pathogenesis, diagnosis and prognosis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-04-22)The incidence of infectious endocarditis (IE) is estimated to 5.9/100.000 inhabitants and year. In recent years there has been an improvement in prognosis mainly due to more sensitive echocardiographic methods and surgery ... -
Gallbladder and pancreatic disease in patients with primary sclerosing cholangitis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-05-21)The aims of this study were to assess the occurrence of gallbladder abnormalities and dysfunction, to evaluate clinically useful biomarkers for premalignancy and malignancy in gallbladder epithelium and to assess presence ... -
Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-01-16)Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish ... -
Molecular specificities of NK cell-mediated recognition of human tumor cells
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-01-22)Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well ... -
Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2006-05-12)The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) ... -
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-03-17)Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ... -
On the immunopathogenesis of HIV infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-08-25)CD8+ T-cell dependent clearance of microbial infections by perforin mediated killing of infected cells is a central component in the combat against viral infections. In HIV-1 infected individuals the incidence of virus ... -
On the role of HMGB1 and resistin in severe sepsis and septic shock
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-12-21)Severe sepsis and septic shock are serious manifestations of infectious diseases. Mortality ranges from over 30 % in severe sepsis up to 60% in septic shock. Early antibiotic treatment and intensive care are mainstays of ... -
DNA methylation and 5-azacytidine in myelodysplastic syndromes : pharmacodynamic, mechanistic and clinical studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-26)Promoter DNA hypermethylation and hence silencing of e.g. tumour suppressor genes is considered to be an important step in carcinogenesis and has been associated with poor outcome in patients with myelodysplastic syndromes ... -
Angiogenesis in myeloproliferative disorders
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-20)The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in ... -
Interferons in antiviral defense and autoimmunity : focus on type 1 diabetes
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-01-04)Type 1 diabetes (T1D) is a disease characterized by the loss of insulin producing beta-cells in the pancreatic islets of Langerhans. Interferons (IFNs), produced by immune cells and infected parenchymal cells, may ... -
Natural antibodies against phosphorylcholine as potential protective factors in atherosclerosis, cardiovascular disease and systemic lupus erythematosus
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2009-05-15)Atherosclerosis is the most important contributor to cardiovascular disease (CVD). Although it was initially considered as a bland lipid storage disease, processes of inflammation and autoimmunity are now considered to ... -
Structural enzymology of oxalate degradation in Oxalobacter formigenes
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2008-01-04)Oxalic acid, as one of nature's most highly oxidised compounds, is toxic to most organisms. It is introduced in the human body in the diet but also as a waste product of cellular metabolism. Mammals do not posses ... -
Antimicrobial peptides and pathogenic Neissera : experimental studies in mouse, man and rat
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2005-08-19)Antimicrobial peptides are important effector molecules of innate immunity. In this thesis, the focus is on antimicrobial peptides of the cathelicidin family, i.e. LL-37 in man, CRAMP in mouse and rCRAMP in rat. Expression ... -
Drug resistance in acute myeloid leukemia : clinical and experimental studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-11-07)The long-term result of chemotherapy in acute myeloid leukemia (AML) is poor, even though a majority of AML patients initially respond to chemotherapy and achieve complete remission (CR). Initially resistant disease as ... -
Genetic modification and mesodermal differentiation of human embryonic stem cells
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2008-10-17)Background: Pluripotent human embryonic stem cells (hESCs) are a resource of great potential, available for research. Their capability to differentiate into any cell of the human body and an unlimited in vitro expansion ... -
Genetic modification of human natural killer cells and possible applications thereof
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-08-25)Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear ...