Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 221-240 of 330
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Studies of LXR and CIDEA function in human adipocytes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-01-18)Obesity, defined as a body mass index of 30 or above, is the result of an imbalance of energy intake and energy expenditure. In the last decade, the obesity prevalence has truly reached epidemic proportions with major ... -
Prognostic and biological implications of epigenetic changes in leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-12-23)The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce. We conducted two retrospective studies in AML. The ... -
On HIV-1 restriction in human dendritic cells and peripheral blood mononuclear cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-12-16)Dendritic cells (DCs) are one of the first cells to encounter HIV-1 during sexual transmission. They may transmit the virus to CD4+ T-cells either locally or in the draining lymph nodes. In the present work, we have focused ... -
Toll-like receptor activation induced changes in dendritic cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-11-14)Dendritic cells (DC) are professional antigen-presenting cells that act as a “bridge” between innate and adaptive immunity by the induction and subsequent orchestration of immune responses. The ligation of Toll-like receptors ... -
Towards a bacterial origin of irritable bowel syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-11-01)Background: The irritable bowel syndrome (IBS) is one of the most prevalent disorders and affects about 15% of the Swedish population. Patients with IBS suffer from abdominal pain and disturbed bowel function. Despite being ... -
Cryoablation of cardiac arrhythmias
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-10-18)This thesis evaluates the safety and efficacy of cryoablation in supraventricular tachyarrhythmias. In Study I, the acute and long-term outcome of cryoablation therapy of typical atrioventricular nodal reentrant ... -
Embryonic and adult cardiac stem cells : molecular, electrophysical and immunological characteristics for cardiac repair
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-09-27)Background: The concept of myocardial regeneration by means of stimulating the endogenous regenerative potential in situ is an attractive approach. This offers distinct advantages to stem cell implantation where the problems ... -
Molecular pathogenesis of refractory anemia with ring sideroblasts (RARS) : role of the mitochondrial iron transporter gene ABCB7
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-08-18)Refractory anemia with ring sideroblasts (RARS) is characterized by anemia, erythroid apoptosis, and mitochondrial ferritin (FTMT) accumulation. Granulocyte-colony-stimulating factor (G-CSF) inhibits some of these features ... -
Human natural killer cell activation and differentiation in health and viral infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-07-28)Natural killer (NK) cells are lymphocytes that belong to the innate immune system. They are important for the early defense against viral infections and provide tumor Immune surveillance against both solid tumors and ... -
Studies on PCSK9 in the regulation of cholesterol metabolism
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-05-26)Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic ... -
Studies on novel interactors in human adipose tissue
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-05-19)Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, ... -
Regulation of human dendritic cells and T cells by adenovirus vectors types 5 and 35 : implications for vaccine design
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-05-19)Following viral infection or vaccination dendritic cells (DC) perform an intricate series of roles at the interface of innate and adaptive immunity. Peripheral DC recognition of pathogen associated molecular patterns ... -
Clinical prognostic markers in chronic lymphocytic leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-05-13)Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. The clinical course for the individual patient is still unpredictable despite ... -
Regulation of B cell function by plasmacytoid dendritic cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-05-06)Dendritic cells (DCs) are early sentinels of pathogen exposure and central in the initiation and orchestration of adaptive immune responses. Apart from the prominent role of DCs in the activation of T cells, DCs have been ... -
Prognostic information from nonmalignant and malignant lymphocytes in follicular lymphoma in relation to therapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-04-19)Follicular lymphoma is the most common indolent lymphoma. It is composed of centrocytes and centroblasts, residing in follicles that also harbour nonmalignant immune and stroma cells. Follicular lymphoma is graded according ... -
Role of cellular immune functions through the course of HIV-1 natural infection in Ugandans
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-04-15)HIV‐1 infection remains a major crisis in sub‐Saharan Africa and more information about disease pathogenesis and immune correlates of protection are needed. Uganda, with a population of approximately 33 million people, has ... -
Streptococcus pyogenes : life within the macrophage
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-03-17)Streptococcus pyogenes is a versatile human pathogen causing a wide array of diseases ranging from uncomplicated throat and skin infections to invasive life- threatening diseases with a mortality rate of up to 60%. It is ... -
Streptococcus pyogenes infections and toxic shock syndrome : molecular epidemiology and immunotherapy
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-03-08)Streptococcus pyogenes, also known as group A streptococcus (GAS), is an important human pathogen causing a wide variety of diseases. One of the most severe diseases is streptococcal toxic shock syndrome (STSS), which is ... -
Immune dysregulation in HIV-1 infected lymphoid tissue
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-04-26)Lymphoid compartments are major sites for HIV-1 replication. We evaluated cytokines, chemokines and immunological effector function at the single cell level in lymphoid tissues in chronically HIV-1 infected patients. HIV-1 ... -
Role of inflammatory and mitochondria genes in adipose tissue and obesity
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-09-28)Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). ...