Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 201-220 of 330
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Clinical studies on the role of eicosanoids in the asthmatic airway inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-10)The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate ... -
Characterization of adipose factors regulated by body weight
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-02)White adipose tissue (WAT) constitutes our most expandable tissue and largest endocrine organ secreting hundreds of polypeptides collectively termed adipokines. Changes in WAT mass induce alterations in adipocyte secretion ... -
Mechanistic studies of APR-246 in leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-04-30)PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore ... -
Roles in innate immune receptors : host – pathogen interactions and strengthening vaccines
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-04-29)During the past decades our knowledge of innate immunology has increased drastically. This has improved our understanding about how innate immune cells can distinguish self from non-self, commensal bacteria from pathogens, ... -
TP53 mutations in myelodysplastic syndromes with deletion of 5q
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-04-18)The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia(s) and increased risk of progression to acute myeloid leukemia (AML). International ... -
Experimental and clinical studies on liver regeneration and hepatocellular carcinoma : roles of redox proteins, iron homeostasis and multikinase inhibition.
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-03-26)Compensatory liver regeneration is triggered by chronic liver injury or surgery and is crucial to maintain tissue homeostasis. The underlying mechanisms which include a whole battery of complex signaling events have been ... -
Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-03-22)Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although ... -
The glucocorticoid receptor as a regulator of cortisol responses in cortisol resistant patients and healthy subjects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-03-18)Glucocorticoids are essential for life, and are involved in growth, reproduction, intermediary metabolism, immune and inflammatory reactions as well as central nervous system and cardiovascular functions. Glucocorticoids ... -
Invariant NKT cells and CD1d in HIV-1 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-12-17)The invariant natural killer T (iNKT) cells are a subset of T lymphocytes that share characteristics of both innate and adaptive immunity. These cells are defined as T cells restricted by the lipid antigen presenting ... -
Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-11-22)Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone ... -
Inflammatory bowel disease, colorectal neoplasia and treatment with ursodeoxycholic acid in primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-11-19)Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease closely associated with inflammatory bowel disease. PSC is progressive and ultimately leads to death or need for liver transplantation. ... -
Addressing cardiovascular risk factors and therapy effects in rheumatoid arthritis : implications for atherosclerosis and cardiovascular disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-11-07)Rheumatoid arthritis (RA) is the prototype of chronic inflammatory disease associated with a 1.5-2 fold increased risk of cardiovascular disease (CVD) and premature mortality. Though traditional CVD risk factors are important ... -
Studies of human dendritic cells in the skin after antigen exposure
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-10-26)Dendritic cells (DCs) act at the interface of innate and adaptive immunity. They are capable of inducing strong effector immune responses to invading pathogens, but also exert important functions in the maintenance of ... -
Rituximab-induced neutropenia : clinical and patophysiological studies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-10-09)Rituximab is a monoclonal antibody directed against the CD20 antigen on normal and neoplastic B-lymphocytes. It was originally developed for treatment of lymphomas as a targeted therapy against CD20 positive non-Hodgkin ... -
Elicitation and enhancement of T and B cell responses
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-10-05)The Major histocompatibility complex class I (MHC-I) has been characterized in such great depth that a number of its key properties are well understood and part of its behavior can even be predicted. It is therefore ... -
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-09-06)The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ... -
Very low energy diets in the treatment of obesity : studies of obstructive sleep apnoea, side-effects, and treatment discontinuation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-05-11)Background: The prevalence of obesity has increased dramatically during the last decades worldwide. Obesity is associated with increased risk of morbidity and mortality, leading to an increased suffering for the individual ... -
Strategies for modulation of dendritic cell responses
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-05-10)With increased knowledge in dendritic cell (DC) biology, innate immune receptors and their ligands, and the shaping of adaptive responses, refined approaches to modulate our immune system are today emerging as treatment ... -
Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-05-07)A century after the initial proposition that the immune system has the capacity to fight against tumors, evading destruction by immune cells is now well recognized as a hallmark of cancer. Recent decades have witnessed ... -
Formation of the inhibitory KIR repertoire in human natural killer cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2012-01-23)Natural killer (NK) cells are lymphocytes of the innate immune system that are able to secrete cytokines and detect virus infected and transformed cells. Contrary to T cells, NK cells recognize targets that lack expression ...