Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 141-160 of 330
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Novel aspects of metabolic regulation and inflammation in human adipocytes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-04-28)The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. The aim of this thesis was to investigate the ... -
Influenza specific T- and B-cell responses in immunosuppressed patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-04-15)Influenza, known as the ‘flu’, is a recurrent acute viral infection that might cause severe inflammation, particularly in vulnerable individuals, i.e. young children, the elderly, and immune-suppressed patients, such as ... -
Clinical and molecular effects of azacitidine in the myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-02-12)The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia and increased risk of leukemic progression. In higher-risk MDS, Azacitidine has ... -
Biliary epithelial cells, the immune system and PSC pathogenesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-01-30)Primary sclerosing cholangitis (PSC) is a chronic, inflammatory liver disease that leads to destruction of the bile duct system. PSC is strongly associated with inflammatory bowel disease, and PSC patients have an increased ... -
Diversity and dynamics of Plasmodium falciparum malaria
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-05-10)The epidemiology of genetic diversity of malaria parasites in relation to clinical parameters, acquisition of immunity and malaria transmission has implications for the development and evaluation of control measures such ... -
Thyroid hormone receptor expression in cardiovascular disease and pharmacology
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-11-19)The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid ... -
Pelvic pouch in ulcerative colitis : surgical refinement and long-term mucosal outcome
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-11-05)The surgical technique in performing restorative proctocolectomy has been extensively developed since its introduction in 1978. Recurrent attacks of inflammation in the neorectal ileal pouch mucosa, pouchitis, well known ... -
Human polymorphonuclear granulocytes in inflammation : studies with an emphasis on nitric oxide
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-04-16)The function of the polymorphonuclear neutrophil granulocyte (PMN) is of vital importance in inflammation. For the defense against infections PMNs are armored with different weapons such as chemotaxis, phagocytosis and ... -
Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-02-19)Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk ... -
Treatment of helicobacter pylori infection : experimental and clinical studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1997-05-23)The general aims of the present study were to investigate the reason for failed H. pylori eradication, and to improve the recommendations for treating H. pylori infection. Our in vitro studies are based on microscopy, ... -
Cholesterolinduced changes in macro- and microvessels in rabbits : effects of antioxidants
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1997-05-09)A hyperlipidemic state induced by cholesterol feeding results in changes in both the structure and function of macro- and microvessels in rabbits. It has been proposed that oxidative modification of lipoproteins might be ... -
Optimization of cyclophosphamide therapy based on pharmacogenetics
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-11-03)Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by ... -
Impaired glucose tolerance in ischemic heart disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-11-18)Background: Diabetes mellitus (DM) and impaired glucose tolerance test (IGT) are well known risk factors for cardiovascular disease (CVD). Individuals with IGT, a prediabetic state, are asymptomatic during many years ... -
Studies on fat cell function in human obesity and insulin resistance
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-09-30)Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ... -
Prevention and treatment of hepatitis B virus infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-06)Despite 25 years of effective vaccines and availability of treatment options for 15 years, hepatitis B virus (HBV) infections continue to be a major global health problem. In Sweden, selective screening and vaccination ... -
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-27)High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as ... -
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-11-05)Obesity has become an important health problem worldwide. It increases the medical risks and affects daily living. Environmental factors such as diet and sedentary lifestyle are likely to be the cause. In Sweden, the number ... -
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-09-03)Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe ... -
Modulation of bile acid and cholesterol metabolism in health and disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-05-07)An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ... -
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-04-02)Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of ...