Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 121-140 of 330
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Dynamic shaping of human NK cell receptor repertoires : implications for NK cell-based immunotherapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-10-20)Natural killer (NK) cells are innate lymphocytes with a potent intrinsic capacity to kill tumor cells, which makes them attractive candidates for cell-based cancer immunotherapy. Advances during the past decade have revealed ... -
Clinical studies in multiple myeloma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-09-23)Multiple Myeloma (MM) is an incurably disease of the bone marrow. It is characterized by the uncontrolled growth of clonal plasma cells (PCs) and leads to production of non-functional gammaglobulin. Clinical features include ... -
Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-08-18)Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined ... -
Studies on cholesterol and bile acid metabolism in relation to plasma lipoproteins
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-06-01)The metabolism of cholesterol and bile acids is tightly controlled but only partially characterized. The liver is responsible for most of the clearance and catabolism of plasma cholesterol, and the hepatocyte expression ... -
The regulatory role of microRNA in human adipocytes and their link to insulin resistance
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-05-30)White adipose tissue (WAT) is a highly plastic organ which secretes a large number of peptide factors termed adipokines. Increased caloric intake increases WAT mass which results in marked alterations in the secretory ... -
Host-pathogen interactions in invasive Staphylococcus aureus infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-05-19)Staphylococcus aureus is a versatile human pathogen causing a wide range of diseases from uncomplicated skin and soft tissue infections to life-threatening invasive diseases like endocarditis, bacteremia, necrotizing ... -
Cell-mediated immunity to flavivirus infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-27)NK cells and T cells constitute a major part of the cell-mediated immune system and play important roles in the host defense against viral infections. Most current knowledge of cell-mediated immune responses to primary ... -
Mechanisms influencing natural killer cell recognition of tumour cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-12)Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ... -
The importance of fat and alcohol for progression and prognosis in chronic liver disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-06)Chronic liver disease is an increasing cause of global morbidity and mortality. The popular belief is that liver disease is caused mainly by alcoholic liver disease or viral hepatitis. However, the most common cause of ... -
Assessment of patients with late diagnosis and missed opportunities in the Swedish HIV-1 epidemic
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-02-22)Discovered in 1983, with a possibility to diagnose since 1985, and with efficient treatment existing now for two decades, HIV-1 still ranks among the top ten causes of death globally. Approximately 40 million people are ... -
Innate immunity in the immunopathogenesis of chronic viral infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-01-27)Natural killer (NK) cells have a key role in control and clearance of viral infections. To carry out this function NK cells are capable of recognising infected cells and responding with induction of apoptosis in these ... -
Antiretroviral drug resistance and treatment outcomes of human immunodeficiency virus type-1 : implications for low and middle income countries
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-12-21)My thesis contains comprehensive studies of antiretroviral treatment (ART) naïve and experienced patients from the beginning of the Swedish HIV-1 epidemic. Paper I was the first study to describe the ART usage and occurrence ... -
Tick-borne encephalitis : clinical and pathogenetic aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-25)The aims of this study were to investigate the morbidity associated with tick-borne encephalitis (TBE) in the acute stage and at long-term follow-up, to identify the possible host risk factors for development of clinical ... -
Optimization of TB/HIV co-treatment in Ethiopian patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-20)Tuberculosis (TB) and HIV infection act with deadly synergy. HIV is the most important risk factor for latent TB reactivation and active TB progression following exposure or reinfection while TB accelerates HIV progression. ... -
Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-02)Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated ... -
Innate immune responses in vivo after antigen administration : implications for vaccine development
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-09-18)Inducing high magnitude of antibodies with epitope breadth over prolonged periods of time is likely a prerequisite to prevent several of the world’s most serious infectious diseases such as HIV-1, malaria and tuberculosis ... -
A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-08-28)HIV is the cause of a chronic, incurable infection in 37 million people worldwide in 2014. This thesis investigates how the immune system detects HIV and how in turn HIV avoids detection by the immune system. The understanding ... -
Biological markers and treatment as prognostic factors in multiple myeloma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-08-10)Multiple myeloma (MM) is an incurable disease with an increasing number of treatment options. The introduction of what are called novel drugs (bortezomib, lenalidomide and thalidomide) was an important step. These ... -
Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-05-21)Exercise-induced bronchoconstriction (EIB) occurs in the majority of asthmatics following vigorous exercise. EIB is caused by a loss of water from the airways creating a hyperosmolar environment in the tissue that in turn ... -
Studies on cholesterol and lipoprotein metabolism : emphasis on diabetes and sugar
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-05-08)Cholesterol has important functions in the body; as a precursor in the synthesis of steroid hormones and bile acids (BAs), and as a component of cellular membranes. However, an elevated level of plasma cholesterol, transported ...