Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 161-180 of 330
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Biophysical aspects of contact dermatitis and its prevention
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-03-05)The skin, one of the largest organs of the body, is composed of three layers: the epidermis, dermis and subcutis. The outer most part of the epidermis i.e., the stratum corneum - serves as a protective barrier between the ... -
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-12-26)Since the start of treatment with allogeneic haematopoietic stem cell transplantation (SCT), cytomegalovirus (CMV) has been one of the most feared complications. With the help of different CMV-protective strategies, the ... -
Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-09-26)This thesis developed a method for economic evaluation in non-fatal chronic progressive diseases, applied to multiple sclerosis (MS) and rheumatoid arthritis (RA). In economic evaluation different treatment strategies are ... -
Rheumatoid arthritis in male patients : sex hormones, bone mineral density and clinical characteristics
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-04-25)The aims of this study were to investigate sex hormones in men with RA and the relation of these hormones with disease characteristics including bone mineral density, as well as to study gender differences in rheumatoid ... -
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-01-24)In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity ... -
Use of primary human hepatocytes for the elucidation of bile acid synthesis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-01-03)In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made: · The major steroid products excreted ... -
In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-11-08)Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity ... -
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-08-30)This thesis investigates the influence of HIV on childhood tuberculosis (TB) in a high TB and HIV endemic setting. It is based on four studies involving the same study population of 522 tuberculous children and their 25 ... -
Undergoing stem-cell transplantation : patients perceptions of symptoms, functional status and health-related quality of life
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-05-24)Stem-cell transplantation (SCT) is one therapy alternative in cases of cancer diseases. The SCT process begins with a course of high-dose chemotherapy with or without irradiation, which results in side- effects that can ... -
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-05-17)The overall aim of this study was to elucidate the influence of HIV infection on the occurrence, clinical presentation, diagnostic yield and transmission of M tuberculosis among consecutive out-patients with symptoms ... -
Skin sensitivity testing : a biophysical approach
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-04-12)The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures. Its large surface area is constantly ... -
Infections in allogeneic stem cell transplanted patients : clinical and immunological aspects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-05-11)In allogeneic haematopoietic stem cell transplantation (HSCT), 30 to 40 % of transplant related mortality is associated with infection complications. This includes invasive bacterial and fungal infection, and interstitial ... -
Immunological properties of dendritic cells in HIV-1 infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-04-20)Dendritic cells (DCs) capture antigens for intracellular processing to form MHC-peptide complexes involved in the generation of antigen specific T cell responses. After encountering microbes, DCs migrate from the periphery ... -
Hidradenitis suppurativa : with special reference to carbon dioxide laser surgery
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-04-13)Hidradenitis suppurativa (HS) is a chronic inflammatory disease with recurrent abscesses. In most cases, it involves the axillar and anogenital regions. In industrialised countries, the prevalence is of 0.3% to 4%, and ... -
Drug resistance in acute myeloid leukemia : pharmacokinetic and in vitro studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-03-16)Chemotherapy has improved clinical outcome in adult acute myeloid leukemia (AML) but still the majority of the patients die of their disease. One important explanation is transport mediated drug resistance resulting in ... -
Metabolic and endocrine function of human adipose tissue with focus on regional differences
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-03-16)The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also ... -
Tick-borne encephalitis : prognosis, immunization and virus strain characterization
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-10-20)The aims were to investigate the morbidity associated with tick-borne encephalitis (TBE) both in the acute phase and at long-term follow-up, to develop a rapid neutralization test for confirmation of TBEV-specific antibody ... -
On-line vectorcardiography during coronary angioplasty and unstable coronary artery disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-09-22)This thesis evaluates the usefulness of continuous vectorcardiography (VCG) in patients undergoing elective coronary angioplasty and in patients with unstable coronary artery disease (CAD), for detection and quantitation ... -
Immunopathology and signalling molecules involved during experimental African trypanosomiasis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-09-21)In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. rhodiense. Trypanosomes are transmitted by ... -
Staphylococcus aureus bacteraemia and endocarditis : epidemiology, short- and long-term mortality
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-11-17)Staphylococcus aureus is a major cause of bloodstream infections and endocarditis. S. aureus bacteraemia (SAB) is associated with substantial morbidity and mortality, and endocarditis is a severe complication. Population-based ...