Doktorsavhandlingar / Doctoral Theses - H2 (BioNut): Recent submissions
Now showing items 61-80 of 299
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Potential novel molecular targets for breast cancer diagnosis and treatment
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-09-09)Breast cancer possesses the highest incidence among cancers in women worldwide, accounting for approximately 26% of all cancers in women. Due to the discovery of specific predictive and prognostic biomarkers, breast ... -
A crystallographic view of egg-sperm interaction
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-08-12)Animal reproduction is a heavily studied biological event, however our knowledge regarding the molecular basis of the recognition between gametes – egg and sperm – still remains very incomplete. In particular, it is currently ... -
Application of next generation sequencing in genetic and genomic studies
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-07-07)Genetic variants that spread along the human genome play vital roles in determining our traits, affecting development and potentially causing disorders. Most common disorders have complex underlying mechanisms involving ... -
Towards smart antisense and antigene therapeutics : design and synthesis of novel oligonucleotide based bioconjugates
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-05-16)The use of nucleic acid technology has been of great importance in life science research. In several clinical trials patients with genetic disease are treated with help of innovations based on oligonucleotide therapy. ... -
Mechanisms of hedgehog signaling activation in cancer development
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-05-02)Hedgehog (HH) signaling has an important role in many physiological processes, and deregulation of this pathway can result in a wide range of malignancies. The aim of this thesis is to identify and evaluate the role of ... -
Epidermal stem cells in physiological tissue regeneration, wound healing and cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-01-29)The mammalian skin is a versatile organ that protects from external harm, regulates the body temperature, and provides the touch sensation. Its epithelium, the epidermis, forms several highly regenerative structures as the ... -
Transcriptional regulation of the human pre-implantation embryo
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-01-07)Millions of couples worldwide have difficulties in conceiving a child. These couples, affected by infertility, suffer from symptoms of stress. The causes of infertility are largely unknown and current available treatment, ... -
Exploring the genome-wide impact of transcription factor AP-1 in breast cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-12-16)AP-1 plays crucial roles in a wide range of cellular processes in breast cancer. Through the dimeric basic leucine zipper (bZIP) domain, the mammalian AP-1 proteins bind to DNA and form homodimers or heterodimers from the ... -
Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-12-10)Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic structural unit of chromatin. Multiple levels of chromatin organization are required to compact DNA into chromosomes, to ensure an accurate ... -
Determination of transcription factor binding specificities
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-11-19)The term "genetic code" refers to the way in which the information encoded in nucleic acids is converted into the amino-acid sequence of proteins. There is however also a second genetic code, one that is used by the cells ... -
Systems microscopy analysis of cell migration
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-11-18)Single cell migration is heterogeneous and a complicated process. It arises from a hugely complex network of multi-scale interactions between molecular and macromolecular entities. Though the full, spatiotemporally resolved ... -
Post-translational modifications in mammary gland development and mammary tumor progression
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-10-09)Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα) signaling and p53 signaling have important roles in breast cancer progression. Therefore, post-translational modifications of ERα and ... -
Mimicking the action of ribonucleases : studies on RNase A and design of PNA based artificial enzymes
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-10-09)A 3’-deoxy-3’-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. Despite that both the vicinal 2-hydroxy ... -
Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-08-21)Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is ... -
Estrogens and lymphoma growth
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-05-25)Lymphomas are generally not considered as endocrine-associated cancers. Nevertheless, most lymphoid malignancies show a gender differencein incidence and prognosis, with males being more affected.The molecular mechanism ... -
Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-05-12)Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence ... -
DNA topoisomerases and nucleosome dynamics in fission yeast
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-05-12)The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, ... -
Toxicity and biocompatibility of nanoparticles, and studies on oxidative stress and DNA damage
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-05-11)Oxidative stress is associated with several diseases, either as a cause or a consequence. Chronic kidney disease (CKD) is one example of a disease in which elevated levels of oxidative stress are frequently reported. ... -
Effects of pharmaceutical modulation of protein aggregation on lifespan in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-02-24)Aging is accompanied by a disruption in various homeostatic networks including those devoted to maintaining protein conformation and integrity. Collectively this maintenance is referred to protein homeostasis or proteostasis. ... -
Epithelial stem cells in Hutchinson-Gilford progeria syndrome
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2015-01-07)Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common ...