Doktorsavhandlingar / Doctoral Theses - H2 (BioNut): Recent submissions
Now showing items 41-60 of 298
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Transcriptional control of liver metabolism and disease by nuclear receptor-corepressor networks
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-05-03)Liver lipid metabolism is coordinated via transcriptional networks composed of transcription factors and coregulators. Disturbance of such networks leads to metabolic dysregulation and is linked to the progression of ... -
Decoding the heterogeneity of skin in homeostasis and regeneration at single-cell resolution
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-12-20)The skin plays a critical role in securing homeostasis in the mammalian body. Its epidermis forms a tight barrier, which separates the internal from the external environment, thereby shielding the body from physical and ... -
Role of GPS2 in epigenome alterations linked to metaflammation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ... -
Objective quantification and analysis of eating behaviour associated with obesity development : from lab to real-life
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)Introduction: The last four decades have seen a marked increase in childhood and adult obesity prevalence, attributed to an “obesogenic” environment. Several genetical, environmental and behavioural factors have been ... -
Regulation and function of ciliary dyslexia candidate genes
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-09-20)Dyslexia is defined as an unexpected difficulty in reading despite normal intelligence, senses and instruction. It is the most common learning disability with estimated 5-10% of the population affected. Its heredity is ... -
Structural studies of proteins essential for fertilization
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-24)Where do babies come from? Even though it sounds like a fairly obvious question, it took more than 200 years to discover that sperm, whose first observation dates back to the 17th century, can penetrate into the oocyte and ... -
The role of RFX transcription factors in neurons and in the human brain
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-15)RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX ... -
Genetics of irritable bowel syndrome and associated gastrointestinal symptoms
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-05-07)Irritable bowel syndrome (IBS) affects more than one in ten individuals worldwide and is the most common cause of gut illness. It is classified according to the symptom-based Rome criteria as a functional gastrointestinal ... -
Understanding the interplay between gut microbiota, gut function and host genes in the generation of gastrointestinal symptoms and disease
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-11-27)Irritable bowel syndrome (IBS) is a multifactorial and complex disease categorized in the functional gastrointestinal disorders (FGIDs) with an intricate pathogenesis yet far from understood. The prevalence and burden of ... -
Role of PAK4 in pancreas development and breast cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-31)PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality ... -
A web- and mobile phone-based obesity prevention intervention in 4-year-olds : a population-based randomized controlled trial
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-27)Background: Childhood overweight and obesity has increased significantly over the past two decades. Many well-conducted obesity prevention trials have been conducted in pre-school aged children but the majority have not ... -
Understanding structural features of biomolecular interactions : from classical simulations to ab initio calculations
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-17)The structures of biomolecules and their interactions dictate their functions. In this thesis, five papers are presented to illustrate how the dynamics of biomolecules can be investigated and derivation of desired thermodynamic ... -
Insight into 5-lipoxygenase biocatalysis and interaction with membrane components
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-05-12)Inflammation is one of the innate defence mechanisms exerted by the human body for protection and to initiate the healing process. Chronic inflammatory reactions can lead to several disease conditions like asthma, allergic ... -
Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-04-12)Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further ... -
The role of estrogens and the microenvironment in lymphoma progression and drug sensitivity
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-03-08)Lymphomas are a group of cancers which originate from lymphatic cells. More than 90% of the lymphomas belong to the group of Non-Hodgkin lymphoma (NHL), which in itself is a non-homogeneous group consisting of different ... -
Stem cells and development : studies on SUFU and LGR5
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-12-16)Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT ... -
GLI1 modulation of the output of hedgehog signaling in human cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-11-11)The Hedgehog (HH) signaling pathway has critical roles in embryonic development and tumorigenesis. Aberrant activation of HH signaling has been known to be involved in several types of malignant tumors. GLI1 is a transcription ... -
Molecular modeling and thermodynamics simulation of nucleic acids
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-11-04)Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures ... -
Identification and functional characterization of gastrointestinal disease genes
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-09-21)The inflammatory bowel diseases (IBD) Crohn’s disease (CD) and ulcerative colitis (UC) are conditions characterized by chronic and relapsing inflammation of the gastrointestinal tract. IBD affects around 2.5 million people ... -
Potential novel molecular targets for breast cancer diagnosis and treatment
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-09-09)Breast cancer possesses the highest incidence among cancers in women worldwide, accounting for approximately 26% of all cancers in women. Due to the discovery of specific predictive and prognostic biomarkers, breast ...