Doktorsavhandlingar / Doctoral Theses - H2 (BioNut): Recent submissions
Now showing items 101-120 of 299
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Characterisation of the novel endoplasmic reticulum chaperone ERDJ5
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2006-11-17)Communication between cells depends to a large extent on interactions between secreted proteins and membrane receptors. Therefore their production and release must be strictly regulated. Proteins that are destined for the ... -
Disassembly and reassembly of the nuclear pore complex
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2006-09-22)The nuclear pore complexes (NPCs) are multiprotein communicative channels spanning the nuclear envelope. In higher eukaryotes NPCs reversibly disassemble during mitosis into distinct nucleoporin subcomplexes. Some cell ... -
Fusion activation in murine leukemia virus
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2006-04-21)This thesis describes the fusion activation in Murine leukaemia virus (MLV). During entry of retroviruses into uninfected cells, the viral and cellular membranes fuse. The fusion process is mediated by the viral envelope ... -
Molecular basis of estrogen receptor antagonism
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2006-01-27)Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined ... -
Intake of fruit and vegetables in European children and their mothers, folate intake in Swedish children and health indicators : overweight, plasma homocysteine levels and school performance
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2005-11-18)An adequate fruit and vegetable intake provides essential nutrients and nutritive compounds and is considered an important part of a healthy lifestyle. Within the Pro Children project, an instrument for assessment of ... -
Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2005-11-24)The chemistry developed in this thesis can be divided into two parts. The first part, which is the major part of the thesis, contains syntheses towards analogues to mutagenic heterocyclic amines found in e.g. meat fried ... -
Structural and functional studies of microsomal glutathione transferase 1
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2005-05-13)The microsomal glutathione transferase 1 (MGST1) is present in high amounts in the endoplasmic reticulum (ER) as an integral homo-trimeric membrane protein with a molecular weight of 51.9 kDa. MGST1 possess glutathione ... -
Studies on growth hormone induced female-characteristic gene transcription in rat liver
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2005-05-06)Growth hormone (GH) secretion is sexually dimorphic, which has an impact on hepatic gene expression. This is particularly pronounced in rats but has also been demonstrated in other species, including humans. The male GH ... -
Ancestral influences on health of grandchildren
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2005-03-22)The late effects in adulthood of nutrition during adolescence, childhood, infancy, and the fetal and embryonic stages of development have attracted much attention in research, but less so the time of development of the ... -
Search for susceptibility loci and candidate genes for breast cancer
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-11-26)Breast cancer is the most frequent cancer among women in the western world. Family history is a wellestablished and important risk factor for breast cancer. Both a population-based twin study and a study based on a large ... -
Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-11-19)This thesis deals with the development of new synthetic methods leading to fused tri- and tetracyclic heterocycles, many of which have interesting biological activity such as antiviral and DNA intercalating properties. The ... -
Protein folding, stability and recognition
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-10-29)Proteins make up for most of the dry mass of a cell and they are highly involved in virtually all cellular processes. The importance of the proteins is reflected by frequent association between dysfunctional proteins and ... -
Design and synthesis of steroid mimetic libraries using solid phase techniques
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-09-10)This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one ... -
Modulation of nuclear receptor activity by a unique class of corepressors
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-09-17)Nuclear receptors comprise a unique family of transcription factors that are crucial regulators of gene expression involved in diverse physiological and developmental processes. The nuclear receptor field has undergone a ... -
Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-09-03)This thesis deals with the synthesis and reactions of indoles, bisindoles, indolocarbazoles and their derivatives. New methods for ring formation of planar, heterocyclic quinones, with the indolo[3,2b]carbazole or ... -
Functional analysis of genetic variants in putative low penetrate breast cancer genes
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-09-03)Paper I & II: CDH1 germline mutations predispose individuals to diffuse gastric cancer, but its role in breast cancer is less clear. Somatic CDH1 mutations were reported to be frequent in lobular tumours (ILC), but they ... -
Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2004-09-01)Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important ... -
Molecular complexities of patched signaling in cancer development
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2004-05-21)Basal Cell Cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. BCCs mainly occur as sporadic tumors but can ... -
In vivo studies of cell cycle regulating proteins in rats during liver regeneration and during promotion of liver carcinogenesis
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2004-05-20)There are more than one hundred different types of cancer in humans. However, the major platform for all types of cancer is automous and uncontrolled cell division and though most types of cancer are possible to treat and ... -
Estrogen receptor signalling in mammary epithelial cells
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2004-05-21)The mammary gland is a complex tissue going through cycles of extensive proliferation and differentiation. Many hormones are involved in the regulation of development of the mammary gland, including estrogen, prolactin and ...