Doktorsavhandlingar / Doctoral Theses - H2 (BioNut): Recent submissions
Now showing items 121-140 of 299
-
The rhomboid family of intramembrane proteases, conserved regulators of cell communication
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2004-05-14)The development of multicellular organisms relies heavily on cell communication. Cells send and receive complex sets of signals, harmonising their growth and differentiation with that of other, often distant, cell ... -
STAT5 expression and regulation in mammary epithelial cells
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2004-01-09)The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). ... -
Effects of 1,25-dihydroxyvitamin D3 and growth hormone on osteoblast-like cells
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2003-10-03)Bone remodeling, which occurs throughout life in both cancellous and cortical bone, involves mainly the osteoblasts and osteoclasts. The osteoblast is responsible for the production of matrix, which later becomes mineralized. ... -
NF-kB in epidermal signal transduction and tumor development
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2002-11-15)The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology ... -
Estrogen receptor b in the urogenital tract of both male and female
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2002-05-24)The central finding of this thesis is that estrogen receptors regulate androgen receptor expression: ERalpha unpregulates AR and ERbeta down-regulates AR. With this theme, we explored the physiological role of an ER-AR ... -
Molecular dynamics studies of water and biomolecules
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2002-05-24)This thesis concerns different areas of molecular dynamics (MD) simulations. In the first part of the thesis the ability of liquid water models to mimic the real bulk water properties and the accuracy of the methods to ... -
Molecular changes in the tumour suppressor genes p53 and CDKN2A/ARF in human urinary bladder cancer
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2002-01-25)Urinary bladder neoplasm is the ninth most common cancer in Europe and the United States. The incidence in Sweden is approximately 32 for men and 9 for women per 105 subjects and year and almost all cases are transitional ... -
Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-12-31)Benzodiazepine alkaloids exhibit a multitude of interesting pharmacological activities. This thesis deals with the development of synthetic methods towards such alkaloids, of which the main efforts can be divided into three ... -
Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-12-21)The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents ... -
Studies on the atypical orphan receptor SHP
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-11-23)Nuclear receptors (NRs) comprise the largest family of transcription factors in eukaryotes and play critical roles in nearly every aspect of vertebrate development and adult physiology. In general, they function as ... -
Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-10-26)Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction ... -
Functions of estrogen receptor b in the metabolism of rodent bone
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-08-31)Estrogens are important for widespread biological functions including regulation of development and maintenance of skeletal tissue. The effects of estrogens are thought to be mediated via two intracellular proteins, estrogen ... -
Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2001-05-25)Late lung development is characterised by extensive cellular differentiation, resulting in a variety of specialised epithelial cell types. Although much is known of the extracellular signalling involved in lung ... -
Toxicological aspects of bile acids and human fecal water on cultured human colon carcinoma cells
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2001-05-11)Colorectal tumorigenesis involves activation of mutations in proto-oncogenes, such as ras and c-myc, as well as mutations that inactivate tumor suppressor genes including the APC and the p53 gene. These genetic events, ... -
HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2001-01-05)The HLA (Human Leukocyte Antigen) region is the most polymorphic in the human genome. The extended polymorphism contributes to the ability both of individuals and populations to combat diversity in the pathogens to which ... -
Expression and regulation of Rad51 in human cells
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2000-11-24)Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in ... -
Cytochrome P450 in the rat brain : characterization and regulation
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2000-11-24)Cytochrome P450s (CYPs) are key enzymes in the metabolism of cholesterol and fatty acids and their derivatives in the body. In the adrenals and gonads these enzymes are involved in steroid hormone biosynthesis, in the liver ... -
Repression of transcription factor NF-[kappa]B by glucocorticoids : a molecular mechanism for their anti-inflammatory and immuno-modulatory effects
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2000-11-21)It has been known since the late 1940s that glucocorticoids (GCs) possess anti-inflammatory activity. Their various uses in the clinic include treatment of, rheumatoid arthritis, asthma and AIM skin diseases and also as ... -
DNA adducts formed by ethene and butadiene : quantitative analysis in rats and humans
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2000-10-20)The present study has focused on DNA adduct formation by two important industrial and environmental chemicals, ethene and butadiene, in rats and humans. Ethene and butadiene are among the 50 chemicals produced in greatest ... -
Molecular progression and clonality or urinary bladder cancer
(Biovetenskaper och näringslära / Biosciences and Nutrition, 2000-09-29)The general aim of this work was to investigate the clonality of multifocal bladder tumours, chromosomal deletions and model the initiation-progression of bladder tumours at a molecular level using microsatellite analysis. ...