Doktorsavhandlingar / Doctoral Theses - C8 (MEB): Recent submissions
Now showing items 221-240 of 250
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Epidemiologic studies of amytrophic lateral sclerosis
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2010-01-08)Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, ... -
Family studies of schizophrenia and pregnancy outcomes
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-12-26)Why do psychiatric diseases run in families? Why do some women tend to have similar obstetric complications in subsequent pregnancies? The overall aim of this thesis was to investigate how genes and environments contribute ... -
Physical activity from the epidemiological perspective : measurement issues and health effects
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-05-26)The aim of this thesis was to increase our understanding of links between physical activity and health. The relationships between physical activity and breast cancer risk and between current physical activity and overall ... -
Exposures in utero and chronic disease : an alternative methodological approach
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2002-08-30)The aims of this thesis were to evaluate maternal and birth characteristics as risk factors for breast cancer and cardiovascular disease later in life, and to assess maternal serum concentrations of insulin-like growth ... -
Factors of importance for self-related health
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-03-10)Even though self-rated health is increasingly accepted as an important measure of health status, there are several uncertainties as to why people differ in their health perception. The extent of age differences across the ... -
Optimization of compliance in epidemiologic research and disease prevention : with special emphasis on PAP-smear screening
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2003-03-14)The aim of this thesis was to investigate factors affecting attendance in screening for cervical cancer, and to evaluate various measures aimed at increasing compliance to self-administered postal questionnaires and screening ... -
Etiology of gastroesophageal reflux
(Institutionen för kirurgisk vetenskap / Department of Surgical Science, 2004-04-16)Although gastroesophageal reflux disease is among the most common disorders at all in Western populations, the etiology is largely unknown. The objective of this thesis is to increase the knowledge of the etiology of reflux ... -
Reasons for non-vaccination
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-05-25)Vaccines are among the most effective public health interventions used today. Population based vaccination programmes are mainly aimed at protecting against common childhood diseases, but other population groups are also ... -
Truncation and missing family links in population-based registers
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-03-07)Studies of familial aggregation of disease routinely use linked population registers to construct retrospective cohorts. Although such resources have provided numerous estimates of familial risk, little is known regarding ... -
Recent trends in the epidemiology of gonorrhoea in Sweden : the role of importation and core groups
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-05-18)In 1997 the gonorrhoea incidence in Sweden started to rise from a low-prevalent level after some 25 years of steady decline. The rise has continued and coincides with similar trends in other sexual transmitted infections ... -
Barrett's oesophagus and metaplasia at the oesophagogastric junction : an epidemiological approach
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-11-03)The aims of this thesis were to estimate the prevalence of Barrett's oesophagus (B0) and related histological aberrations, to investigate agreement between endoscopy and histology regarding the diagnosis of BO and to ... -
Factors affecting attendance at population-based mammography screening
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2002-01-11)The aim of the studies described in this thesis was to explore factors affecting attendance at outreach mammography screening, and to assess possible associations between socioeconomic factors and breast cancer ... -
Genetic epidemiological studies of the functional somatic syndromes : chronic widespread pain and chronic fatigue
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2007-02-02)Fibromyalgia and chronic fatigue syndrome are two symptom-defined conditions with many physical symptoms in common, such as muscle pain, fatigue, unrefreshing sleep, and impairment in memory or concentration. These two ... -
Pregnancy related risk factors for breast cancer
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2003-12-19)Pregnancies offer a life-long reduction in breast cancer risk. It has repeatedly been shown that both number of pregnancies and age at first birth affect the future breast cancer risk. The mechanisms for this protection ... -
Epidemiological studies of the etiology of pancreatic cancer
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-01-11)Pancreatic cancer is one of the most lethal human cancers with less than 5% of patients surviving 5 years. Despite an urgent need for primary prevention, little is known about the etiology of this cancer. This thesis was ... -
The use of the world wide web in epidemiological research
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2006-10-06)The world is becoming smaller. Through technical innovations all kind of communication is simplified, people come closer, and borders are erased. The Internet plays a major part in this process not only through the ... -
Causal inference in epidemiological research
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2009-01-16)Traditionally, statistics has been viewed as the branch of science which deals with association. Many epidemiological research questions, however, are concerned with causation, not association. In this thesis we ... -
Statistical methodology for testing genetic association in family-based studies
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-04-25)This thesis is concerned with family-based studies of association between genetic markers and binary traits. A special point of interest in family-based association studies is to separate the within family correlation and ... -
Short and long term effects of bacterial gastrointestinal infection
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-05-09)The objectives of this thesis were to increase our understanding of the mortality and complications associated with bacterial gastrointestinal infections, with focus on Salmonella and Campylobacter enteritis. The effect ... -
Population-based family studies : genetic contribution to cancer development and survival?
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2008-10-09)Cancer affects essentially everyone, directly or indirectly. The aim of this thesis was to study the genetic and environmental factors in cancer development and survival. Our studies were based on a record linkage between ...