Doktorsavhandlingar / Doctoral Theses - C6 (IMM): Recent submissions
Now showing items 61-80 of 321
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Occupational exposure to polycyclic aromatic hydrocarbons and early biomarkers related to cardiovascular disease and cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-03-05)Polycyclic aromatic hydrocarbons (PAH) are omnipresent environmental pollutants composed of fused benzene rings and mainly produced by incomplete combustion of organic material. PAH exposure has been associated with increased ... -
Phospholipid related antigens and protective mechanisms : implications for cardiovascular diseases, human autoimmunity and inflammation
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-02-21)The pathogenesis of chronic inflammation, a common denominator in cardiovascular, metabolic and systemic autoimmune diseases, is influenced by a number of genetic, metabolic and immunological risk factors. Oxidation of ... -
Occupational exposure to chemicals and cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-02-14)We spend a lot of our time at work and the exposures in our work environment have a great influence on our health. Certain occupational groups, like firefighters, are exposed to a large number of chemicals and an increased ... -
Novel immunologic cellular mechanisms in atherosclerosis and potential therapeutic implications
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-01-15)Atherosclerosis, an arterial ailment, is a major cause of cardiovascular diseases (CVD), which cause more than 17 million deaths each year and the number is expected to rise. In recent years atherosclerosis has been shown ... -
Deciphering microglia plasticity in glioma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-01-11)Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ... -
Mitochondria targeting and its consequences for cell death in neuroblastoma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-12-14)Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. ... -
The impact of transcriptional mutagenesis on cellular homeostasis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-16)DNA is exposed to chemical and physical agents that represent a continuous threat to its integrity by formation of DNA lesions. Despite the existence and efficiency of DNA repair systems in cells, some lesions may not be ... -
Early-life selenium status and cognitive development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-12)Selenium is an essential element that is found in food sources such as meat, fish, and cereals. The essentiality of selenium was demonstrated in the 1950s, and the interest in its health effects has been growing ever since. ... -
Cellular effects of nickel and nickel oxide nanoparticles : focus on mechanisms related to carcinogenicity
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-02)There has been a rapid increase in the production and usage of nanomaterials during the last decade and therefore it is of great importance to properly investigate safety of these materials. This thesis specifically focuses ... -
Innate immune airway responses after exposure to ultrafine and ambient particles : in vivo and in vitro models
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-10-04)Inhalation of ultrafine and ambient particles in the air triggers a response in the innate immune system of the airways. This thesis explores measures to reduce exposure to organic dust, to dampen the adverse immune effects ... -
Quantification of inflammatory mediators to explore molecular mechanisms and sub-phenotypes of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-09-07)This thesis summarizes a series of studies using liquid chromatography coupled to mass spectrometry methodologies to quantify metabolites of fatty acids (i.e., oxylipins) and histamine in different samples from experimental ... -
Evidence by interaction : a new role of caspase-2
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-08-10)Caspase-2 is the best conserved member of the caspase family. Although being known to mediate cell death following DNA damage, many studies have implicated that this protease regulates a variety of cellular processes. ... -
Occupational skin exposure to cobalt : origin and fate
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-25)Exposure to cobalt is not without risk. Besides adverse health effects on the respiratory system, cobalt is one of the most important sensitising metals with a contact allergy prevalence of 2.2% in the general population. ... -
Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-17)It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against ... -
Characterizing chemical exposure : focus on children's environment
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-07)Children are constantly exposed to chemicals in food, water, dust, air and consumer products. Compared to adults, children often have a higher exposure to chemicals due to physical and behavioural factors. Because of their ... -
Use of novel statistical methods in assessing particulate air pollution and evaluating its association with mortality in China
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-30)Particle matter (PM) has been associated with numerous adverse health effects including cardiovascular disease, chronic obstructive pulmonary disease and lung cancer in experimental studies and observation studies. The ... -
Long-term exposure to transportation noise in relation to metabolic and cardiovascular outcomes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-26)Transportation noise exposure is increasing because of rapid urbanization and transportation growth. Environmental noise exposure affects a large part of the population and gives rise to widespread annoyance and sleep ... -
Neutrophil extracellular traps : function in infectious and non-Infectious conditions
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-12)Neutrophil extracellular traps (NETs) are composed of a backbone of chromatin, decorated with microbicidal peptides and proteolytic enzymes, and are used by neutrophils as a weapon against pathogens. Since their initial ... -
Overweight in relation to allergic disease in childhood and adolescence
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-03-28)The prevalences of childhood overweight and allergic diseases have increased in parallel during the last decades. The overall aim of this thesis was to investigate the associations between overweight (maternal and childhood) ... -
Mathematical programming for optimal probability weighting
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-03-23)In spite of the fact that probability weighting is widely used in statistics to correct for unequal sampling, control for confounding, and handle missing data, it has two main limitations. First, statistical inferences may ...