Now showing items 1-20 of 261

    • In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides 

      Bakker, Joanne (Inst för neurovetenskap / Dept of Neuroscience, 2020-09-10)
      A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, ...
    • Limb ownership and voluntary action: human behavioral and neuroimaging studies 

      Abdulkarim, Zakaryah (Inst för neurovetenskap / Dept of Neuroscience, 2020-08-05)
      To be able to interact with our surroundings in a goal directed manner, we need to have sense what our body is made up of as well as a sense of being able to control our body. These two experiences, the sense of body ...
    • Neuromodulation shapes interneuron communication in the mouse striatum 

      Dorst, Matthijs Constantijn (Inst för neurovetenskap / Dept of Neuroscience, 2020-07-24)
      A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of ...
    • Idiopathic intracranial hypertension in Sweden : epidemiological studies focused on incidence and risk factors 

      Sundholm, Anna (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-07)
      Idiopathic intracranial hypertension (IIH) is a disorder which is not that unusual for neurologists and ophthalmologists to meet in clinical practice even though it only affects around 1 per 100,000 individuals. It gives ...
    • Inter- and intracellular resistance and vulnerability in motor neuron diseases 

      Nijssen, Jik (Inst för neurovetenskap / Dept of Neuroscience, 2020-05-06)
      Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are fatal diseases presenting with degeneration and loss of lower motor neurons in the brainstem and spinal cord. However, oculomotor and trochlear ...
    • The role of dopaminergic and cholinergic modulation on the striatal network : a computational investigation 

      Lindroos, Robert (Inst för neurovetenskap / Dept of Neuroscience, 2020-04-16)
      The famous words from the French philosopher René Descartes (1596-1650), “I think therefore I am”, proclaims that since we are thinking we must also exist. At the time when this was stated, very little was known ...
    • Membrane mechanisms during exo- and endocytosis in excitable cells 

      Arpino, Gianvito (Inst för neurovetenskap / Dept of Neuroscience, 2020-04-09)
      Excitable cells, like endocrine cells and neurons release hormones and transmitters through exocytosis to mediate many important functions, such as stress responses, immune responses, control of blood glucose, and synaptic ...
    • The functional organisation of basal ganglia inputs 

      Johansson, Yvonne (Inst för neurovetenskap / Dept of Neuroscience, 2020-04-07)
      The basal ganglia allow organisms to adjust their behaviour according to changes in their internal state or their environment. One essential prerequisite for the selection and execution of appropriate movements is the ...
    • Regulations of neuronal plasticity by the Nogo system 

      Smedfors, Gabriella (Inst för neurovetenskap / Dept of Neuroscience, 2020-04-02)
      Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons ...
    • Molecular and functional neuroanatomy of mood disorder circuits 

      Märtin, Antje (Inst för neurovetenskap / Dept of Neuroscience, 2020-03-26)
      The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for ...
    • Brain development in a dish 

      Pronk, Robin Johan (Inst för neurovetenskap / Dept of Neuroscience, 2020-03-06)
      This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole ...
    • Analysis of basic motor behaviors in quadrupeds 

      Vemula, Manideep Gupta (Inst för neurovetenskap / Dept of Neuroscience, 2020-01-30)
      Ability to perform locomotion in different directions and maintain upright body posture is crucial for normal life. At present, mice, which allows employing genetic approaches, are widely used in studying the locomotor ...
    • Organization of brain circuits that control motivated behaviors 

      Tzortzi, Ourania (Inst för neurovetenskap / Dept of Neuroscience, 2020-01-22)
      Eudemonia (Greek: εὐδαιμονία) is an anthropocentric term describing the absolute well-being in the Aristotelian ethics, along with the terms “arête” (virtue) and “phronesis” (wisdom from an ethical and practical point ...
    • On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex 

      Ährlund-Richter, Sofie (Inst för neurovetenskap / Dept of Neuroscience, 2019-12-13)
      This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a ...
    • Single cell analysis of iPS derived neural stem cells and neurons 

      Lam, Matti (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-21)
      In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell ...
    • On the evolutionary origin of the vertebrate cortex 

      Suryanarayana, Shreyas M (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-07)
      The aim of this thesis is to dissect out the minimalistic ancestral neural hardware, which has been conserved in homologue structures of the cerebral cortex and in particular the neocortex, across vertebrates. For this ...
    • Human induced pluripotent stem cells in regenerative medicine 

      Uhlin, Elias (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-29)
      Human induced pluripotent (iPS) cells offer a theoretically inexhaustible cell source for the derivation of any cell type and are a promising tool in regenerative medicine. Cells can be derived from the recipients own ...
    • Generation and investigation of neural microenvironment in health and disease 

      Lewicki, Jakub (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-09)
      Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
    • Is modulation of glucocerebrosidase a viable new treatment for Parkinson's disease? 

      Zurbruegg, Mark (Inst för neurovetenskap / Dept of Neuroscience, 2019-09-30)
      Background: Parkinson`s disease is the second most prevalent neurodegenerative disorder. There are currently no treatments that cure Parkinson’s disease (PD) or slow its progression. There is therefore an urgent need for ...
    • Home-cage monitoring of mouse behaviours across life-span 

      Pernold, Karin (Inst för neurovetenskap / Dept of Neuroscience, 2019-04-25)
      Background and aim: The academic research involving animal testing is struggling with problems of reproducibility and a few of the specific reasons pointed out are for example insufficient reporting of animal strains and ...