Now showing items 1-20 of 248

    • On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex 

      Ährlund-Richter, Sofie (Inst för neurovetenskap / Dept of Neuroscience, 2019-12-13)
      This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a ...
    • Single cell analysis of iPS derived neural stem cells and neurons 

      Lam, Matti (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-21)
      In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell ...
    • On the evolutionary origin of the vertebrate cortex 

      Suryanarayana, Shreyas M (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-07)
      The aim of this thesis is to dissect out the minimalistic ancestral neural hardware, which has been conserved in homologue structures of the cerebral cortex and in particular the neocortex, across vertebrates. For this ...
    • Human induced pluripotent stem cells in regenerative medicine 

      Uhlin, Elias (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-29)
      Human induced pluripotent (iPS) cells offer a theoretically inexhaustible cell source for the derivation of any cell type and are a promising tool in regenerative medicine. Cells can be derived from the recipients own ...
    • Generation and investigation of neural microenvironment in health and disease 

      Lewicki, Jakub (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-09)
      Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
    • Is modulation of glucocerebrosidase a viable new treatment for Parkinson's disease? 

      Zurbruegg, Mark (Inst för neurovetenskap / Dept of Neuroscience, 2019-09-30)
      Background: Parkinson`s disease is the second most prevalent neurodegenerative disorder. There are currently no treatments that cure Parkinson’s disease (PD) or slow its progression. There is therefore an urgent need for ...
    • Home-cage monitoring of mouse behaviours across life-span 

      Pernold, Karin (Inst för neurovetenskap / Dept of Neuroscience, 2019-04-25)
      Background and aim: The academic research involving animal testing is struggling with problems of reproducibility and a few of the specific reasons pointed out are for example insufficient reporting of animal strains and ...
    • Investigations into the distribution and function of nucleobindin 1 

      Williams, Paul (Inst för neurovetenskap / Dept of Neuroscience, 2019-03-14)
      The nucleobindin proteins (NUCB1 and NUCB2) are both characterised by DNA- and calcium-binding motifs. The functionality of these motifs has been demonstrated, but has not yet led to the identification of a role for either ...
    • Molecular regulation of somatosensory neuron development 

      Wang, Yiqiao (Inst för neurovetenskap / Dept of Neuroscience, 2019-01-30)
      The somatosensory system of vertebrates perceives and transmits a variety of information from both external and internal environments to the central nervous system where an integrated response is established leading to ...
    • Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery 

      Lundin, Anders (Inst för neurovetenskap / Dept of Neuroscience, 2018-12-12)
      Human brain evolution has resulted in a cognitive superiority compared to all other animals. Unique cortical structures and expanding progenitor populations have been associated with the possibility for developing a ...
    • Novel technologies for studies of structural and functional connections 

      Migliori, Bianca (Inst för neurovetenskap / Dept of Neuroscience, 2018-11-30)
      To understand the mechanisms underlying the correct functioning of an organ it is important to study its architecture and how the interactions between cells are leading to a specific function. Specifically, the connections ...
    • Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland 

      Hellysaz, Arash (Inst för neurovetenskap / Dept of Neuroscience, 2018-11-23)
      The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome ...
    • On innate behaviors : focus on parental behavior and aggression 

      Stagkourakis, Stefanos (Inst för neurovetenskap / Dept of Neuroscience, 2018-10-26)
      The neural substrates orchestrating a number of social behaviors, including parental behavior and aggression, are known to exist in the hypothalamus. Through the control of the pituitary gland, the hypothalamus regulates ...
    • Novel tools for the study and diagnosis of bacterial infections : exploring the intersection of microbiology and microfabrication 

      Antypas, Charalampos (Inst för neurovetenskap / Dept of Neuroscience, 2018-09-18)
      The alarming increase in antibiotic resistance calls for new approaches to study and diagnose bacterial infections. In my thesis, I worked at the intersection of microbiology, microfabrication, and optical probes to ...
    • The development and potential of spinal cord stem and progenitor cells 

      Li, Xiaofei (Inst för neurovetenskap / Dept of Neuroscience, 2018-08-28)
      Spinal cord injury (SCI) is an incurable condition, which is mainly due to the highly limited regenerative potential of the adult spinal cord. The discovery of ependymal cells as the source of spinal cord stem cells raises ...
    • Interneuron diversity and function in the zebrafish locomotor circuits 

      Björnfors, Eva Rebecka (Inst för neurovetenskap / Dept of Neuroscience, 2018-05-23)
      One of the most essential features of an animal’s behavior is the ability to navigate and interact with its environment. The generation of the locomotor rhythm is carried out by networks of neurons in the spinal cord, so ...
    • Non-motor symptoms in Parkinson’s disease : modeling and mechanisms 

      Masini, Débora (Inst för neurovetenskap / Dept of Neuroscience, 2018-04-26)
      Parkinson’s disease (PD) is a common neurodegenerative disorder, typically characterized by the progressive death of midbrain dopaminergic neurons projecting from the substantia nigra to other areas within the basal ...
    • Cellular models of human brain disorders from skin to brain 

      Shahsavani, Mansoureh (Inst för neurovetenskap / Dept of Neuroscience, 2018-04-12)
      Studying human brain development and disorders is very challenging. In the absence of comparable model organisms, human-related models, and limitations to obtain live cells from the human brain, induced Pluripotent Stem ...
    • Mapping brain circuits : anatomy, connectivity and function 

      Xuan, Yang (Inst för neurovetenskap / Dept of Neuroscience, 2018-04-06)
      To decipher neural circuits anatomy is the central basis for all kinds of neurobiological studies. Here in this thesis, I will start with extensive overview of the current methods that have been intensively employed in ...
    • Transcriptional regulation of neural development and degeneration 

      Gaudenzi, Giulia (Inst för neurovetenskap / Dept of Neuroscience, 2018-03-07)
      The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, ...