Now showing items 1-20 of 253

    • Regulations of neuronal plasticity by the Nogo system 

      Smedfors, Gabriella (Inst för neurovetenskap / Dept of Neuroscience, 2020-04-02)
      Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons ...
    • Molecular and functional neuroanatomy of mood disorder circuits 

      Märtin, Antje (Inst för neurovetenskap / Dept of Neuroscience, 2020-03-26)
      The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for ...
    • Brain development in a dish 

      Pronk, Robin Johan (Inst för neurovetenskap / Dept of Neuroscience, 2020-03-06)
      This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole ...
    • Analysis of basic motor behaviors in quadrupeds 

      Vemula, Manideep Gupta (Inst för neurovetenskap / Dept of Neuroscience, 2020-01-30)
      Ability to perform locomotion in different directions and maintain upright body posture is crucial for normal life. At present, mice, which allows employing genetic approaches, are widely used in studying the locomotor ...
    • Organization of brain circuits that control motivated behaviors 

      Tzortzi, Ourania (Inst för neurovetenskap / Dept of Neuroscience, 2020-01-22)
      Eudemonia (Greek: εὐδαιμονία) is an anthropocentric term describing the absolute well-being in the Aristotelian ethics, along with the terms “arête” (virtue) and “phronesis” (wisdom from an ethical and practical point ...
    • On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex 

      Ährlund-Richter, Sofie (Inst för neurovetenskap / Dept of Neuroscience, 2019-12-13)
      This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a ...
    • Single cell analysis of iPS derived neural stem cells and neurons 

      Lam, Matti (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-21)
      In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell ...
    • On the evolutionary origin of the vertebrate cortex 

      Suryanarayana, Shreyas M (Inst för neurovetenskap / Dept of Neuroscience, 2019-11-07)
      The aim of this thesis is to dissect out the minimalistic ancestral neural hardware, which has been conserved in homologue structures of the cerebral cortex and in particular the neocortex, across vertebrates. For this ...
    • Human induced pluripotent stem cells in regenerative medicine 

      Uhlin, Elias (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-29)
      Human induced pluripotent (iPS) cells offer a theoretically inexhaustible cell source for the derivation of any cell type and are a promising tool in regenerative medicine. Cells can be derived from the recipients own ...
    • Generation and investigation of neural microenvironment in health and disease 

      Lewicki, Jakub (Inst för neurovetenskap / Dept of Neuroscience, 2019-10-09)
      Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
    • Is modulation of glucocerebrosidase a viable new treatment for Parkinson's disease? 

      Zurbruegg, Mark (Inst för neurovetenskap / Dept of Neuroscience, 2019-09-30)
      Background: Parkinson`s disease is the second most prevalent neurodegenerative disorder. There are currently no treatments that cure Parkinson’s disease (PD) or slow its progression. There is therefore an urgent need for ...
    • Home-cage monitoring of mouse behaviours across life-span 

      Pernold, Karin (Inst för neurovetenskap / Dept of Neuroscience, 2019-04-25)
      Background and aim: The academic research involving animal testing is struggling with problems of reproducibility and a few of the specific reasons pointed out are for example insufficient reporting of animal strains and ...
    • Investigations into the distribution and function of nucleobindin 1 

      Williams, Paul (Inst för neurovetenskap / Dept of Neuroscience, 2019-03-14)
      The nucleobindin proteins (NUCB1 and NUCB2) are both characterised by DNA- and calcium-binding motifs. The functionality of these motifs has been demonstrated, but has not yet led to the identification of a role for either ...
    • Molecular regulation of somatosensory neuron development 

      Wang, Yiqiao (Inst för neurovetenskap / Dept of Neuroscience, 2019-01-30)
      The somatosensory system of vertebrates perceives and transmits a variety of information from both external and internal environments to the central nervous system where an integrated response is established leading to ...
    • Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery 

      Lundin, Anders (Inst för neurovetenskap / Dept of Neuroscience, 2018-12-12)
      Human brain evolution has resulted in a cognitive superiority compared to all other animals. Unique cortical structures and expanding progenitor populations have been associated with the possibility for developing a ...
    • Novel technologies for studies of structural and functional connections 

      Migliori, Bianca (Inst för neurovetenskap / Dept of Neuroscience, 2018-11-30)
      To understand the mechanisms underlying the correct functioning of an organ it is important to study its architecture and how the interactions between cells are leading to a specific function. Specifically, the connections ...
    • Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland 

      Hellysaz, Arash (Inst för neurovetenskap / Dept of Neuroscience, 2018-11-23)
      The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome ...
    • On innate behaviors : focus on parental behavior and aggression 

      Stagkourakis, Stefanos (Inst för neurovetenskap / Dept of Neuroscience, 2018-10-26)
      The neural substrates orchestrating a number of social behaviors, including parental behavior and aggression, are known to exist in the hypothalamus. Through the control of the pituitary gland, the hypothalamus regulates ...
    • Novel tools for the study and diagnosis of bacterial infections : exploring the intersection of microbiology and microfabrication 

      Antypas, Charalampos (Inst för neurovetenskap / Dept of Neuroscience, 2018-09-18)
      The alarming increase in antibiotic resistance calls for new approaches to study and diagnose bacterial infections. In my thesis, I worked at the intersection of microbiology, microfabrication, and optical probes to ...
    • The development and potential of spinal cord stem and progenitor cells 

      Li, Xiaofei (Inst för neurovetenskap / Dept of Neuroscience, 2018-08-28)
      Spinal cord injury (SCI) is an incurable condition, which is mainly due to the highly limited regenerative potential of the adult spinal cord. The discovery of ependymal cells as the source of spinal cord stem cells raises ...