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  • Cellular models of human brain disorders from skin to brain 

    Shahsavani, Mansoureh (Inst för neurovetenskap / Dept of Neuroscience, 2018-04-12)
    Studying human brain development and disorders is very challenging. In the absence of comparable model organisms, human-related models, and limitations to obtain live cells from the human brain, induced Pluripotent Stem ...
  • Mapping brain circuits : anatomy, connectivity and function 

    Xuan, Yang (Inst för neurovetenskap / Dept of Neuroscience, 2018-04-06)
    To decipher neural circuits anatomy is the central basis for all kinds of neurobiological studies. Here in this thesis, I will start with extensive overview of the current methods that have been intensively employed in ...
  • Transcriptional regulation of neural development and degeneration 

    Gaudenzi, Giulia (Inst för neurovetenskap / Dept of Neuroscience, 2018-03-07)
    The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, ...
  • Bacterial physiology and its role in antibiotic refractoriness 

    Gkotzis, Spyridon (Inst för neurovetenskap / Dept of Neuroscience, 2018-01-22)
    The pathological outcome of a bacterial infection depends on the interplay among the host’s innate defenses, the virulence arsenal of the pathogen and antibiotic treatment strategies. Understanding this interplay will ...
  • Studies of amyloid precursor protein trafficking and processing 

    Xu, Shaohua (Inst för neurovetenskap / Dept of Neuroscience, 2018-01-04)
    Alzheimer’s disease (AD) is the most common form of neurodegenerative disease that slowly impairs memory and thinking abilities. Abnormal accumulation and aggregation of amyloid β peptides (Aβ), derived from proteolytic ...
  • On functions of neurotrophic factors in taste buds and teeth 

    Vukmanovic Nosrat, Irina (Inst för neurovetenskap / Dept of Neuroscience, 2017-11-24)
    Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). Among the common ...
  • The role of ABC transporters and inflammation in drug-resistant epilepsy 

    Weidner, Lora Deuitch (Inst för neurovetenskap / Dept of Neuroscience, 2017-11-16)
    This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation. With regard ...
  • Prevention of bacterial colonization in hospital-acquired infections using electrically conducting polymers 

    Gomez-Carretero, Salvador (Inst för neurovetenskap / Dept of Neuroscience, 2017-11-16)
    Biofilms are bacterial assemblies developed as response to adverse environmental conditions and external threats. Within a biofilm, a complex and highly regulated internal architecture is developed, resulting in a network ...
  • Organization of basal ganglia circuits 

    Fürth, Daniel (Inst för neurovetenskap / Dept of Neuroscience, 2017-10-17)
    Anatomical regions and how we define boundaries between and within structures in the brain put a constraint on our understanding of the brain. More than a century of research on the brain has revealed its fundamental ...
  • Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors 

    Conti, Mirko (Inst för neurovetenskap / Dept of Neuroscience, 2017-10-02)
    The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric ...
  • Touching cognition : somatosensory processing and plasticity deficits in mouse barrel cortex 

    Juczewski, Konrad (Inst för neurovetenskap / Dept of Neuroscience, 2017-06-07)
    Senses together with thoughts and experience are key factors that shape our cognition. Touch is an important source of sensory information. Disturbances to the development of the somatosensory system have serious consequences ...
  • Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking 

    Nigam, Saket Milind (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-26)
    Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ...
  • From movement to skill : neural and behavioral mechanisms of motor sequence learning 

    Müβgens, Diana (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-24)
    How do we learn new movements? The simple answer to this question is Through practice! Yet, a better response might be What aspect of motor learning are we talking about? Our capacity for learning new skills and for ...
  • Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions 

    Choong, Ferdinand Xiankeng (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-08)
    A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity. The Tissue Microbiology approach overcomes this by ...
  • Neural circuitry mechanisms in decision-making 

    Wang, Xinming (Inst för neurovetenskap / Dept of Neuroscience, 2017-04-07)
    The brain is the exclusive organ that makes decisions for humans and the society. In this thesis, I will discuss recent advances in the understanding of neuroscientific mechanisms in decision-making. Decision-making is not ...
  • Body-ownership and visual perception 

    Hoort, Björn van der (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-30)
    The idea that our body plays an important role in visual perception has a long history in storytelling and philosophy. Some ideas are very intuitive. For example, few will disagree with the notion that smaller people ...
  • Gut microbes and the developing brain 

    Arentsen, Tim (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-17)
    The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A ...
  • Molecular determinants of endocannabinoid-mediated brain development 

    Calvigioni, Daniela (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-10)
    The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous ...
  • Identification of pathways of degeneration and protection in motor neuron diseases 

    Nichterwitz, Susanne (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-09)
    Motor neuron diseases preferentially affect specific neuronal populations with distinct clinical features even if disease-causing genes are expressed in many cell types. In spinal muscular atrophy (SMA), somatic motor ...
  • Calcium-binding proteins as markers and functional determinants of neurons in pain networks 

    Zhang, Mingdong (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-02)
    The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord ...

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