Now showing items 1-20 of 284

    • Assessing the importance of rare genetic variants for drug response 

      Zhou, Yitian (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-27)
      Inter-individual variability in drug response is commonly observed in pharmacological treatment, resulting in 40-70% of patients suffering from low drug efficacy or adverse drug reactions. These negative ...
    • Long-term outcomes after trauma and intensive care 

      Oelreich, Erik von (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-25)
      The goals of trauma and critical care are twofold: to prevent short- and long-term mortality and to return the patient to an independent life. With the development of modern trauma care including technical advancements ...
    • WNT/Frizzled signaling : illuminating the road towards pathway selectivity 

      Bowin, Carl-Fredrik (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-21)
      Cells sense and respond to their environment via receptors embedded in the plasma membrane. Receptors allow flow of information from outside to the inside of the cell and are generally regulated by extracellular molecules ...
    • Mechanisms of inter-organ crosstalk mediated by tryptophan metabolism 

      da Silva, Paula Sofia Valente (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-09-28)
      Physical exercise and nutrition balance the “energy in-energy out” equilibrium that keeps the system at a dynamic homeostasis, energetically speaking. However, this is a simplistic vision of a dynamic system that is in ...
    • Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms 

      Rudjito, Resti (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-26)
      Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles ...
    • Sex and gender aspects on intensive care : access, intensity and outcome 

      Zettersten, Erik (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-06)
      There is an underlying assumption in society that critically ill patients are admitted to an intensive care unit (ICU) based on their illness severity coupled with their comorbidities, and that other variables are ...
    • The kynurenine pathway in body and brain : relation with physical exercise and mental health 

      Trepci, Ada (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-04-29)
      The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better ...
    • Prediction of psychological and physical morbidity after critical illness and intensive care unit stay 

      Milton, Anna (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-01-11)
      A large proportion of survivors of critical illness and intensive care unit stay suffer from post- intensive care syndrome (PICS), consisting of psychological, physical and cognitive problems. These problems can persist ...
    • Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides 

      Faka Schulte, Anthi (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)
      Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. ...
    • From brain to muscle and back : novel approaches to harness the benefits of exercise 

      Kelahmetoglu, Yildiz (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)
      As the world population is growing older and more sedentary every day, the need for new approaches to combat chronic diseases grows steadily. Physical exercise improves health and reduces the risk of developing a plethora ...
    • Perioperative risk factors and outcomes 

      Hallqvist, Linn (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-24)
      Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ...
    • MRI sequences for detection of acute pulmonary embolism 

      Vargas Paris, Roberto (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-19)
      In recent years a range of imaging techniques have emerged to help diagnose patients with suspected acute Pulmonary Embolism (PE). This is particularly useful for those who are contraindicated (renal failure or allergies) ...
    • Facilitating precision medicine through analysis of next-generation sequencing projects 

      Xiao, Qingyang (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-18)
      Precision medicine constitutes an emerging strategy that aims at the individualization of healthcare by considering the personal molecular features and environmental factors of the patient in question. Genetic biomarkers ...
    • Dietary nitrate and the microbiota : modulators of metabolic function 

      Moretti, Chiara (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-12)
      Nitric oxide (NO) deficiency represents a known feature of cardiovascular and metabolic diseases as well as natural aging. The NO metabolites nitrate and nitrite have long been considered as health-threatening food components ...
    • SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology 

      Heras Arribas, Gabriel Antonio (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-25)
      The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an ...
    • Exercise-induced molecular mechanisms in untrained and life-long highly trained individuals 

      Reitzner, Stefan Markus (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-21)
      Regular physical activity results in extensive systemic and functional adaptation effects in the human body that contribute to physical performance, such as muscular strength and endurance, and can have beneficial health ...
    • Current diagnostic aspects on acute and chronic pulmonary embolism : MRI in acute pulmonary embolism, CT in chronic thromboembolic pulmonary hypertension and what the radiologists actually know 

      Nordgren Rogberg, Anna (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)
      Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ...
    • Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health 

      Manti, Maria (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-17)
      The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ...
    • The role of dietary nitrate in regulation of blood pressure and metabolism 

      Sundqvist, Michaela (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)
      A diet rich in vegetables is recommended for health in general and is also associated with lower blood pressure. Research suggests that inorganic nitrate present in leafy green vegetables could be a contributing factor ...
    • Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance 

      Tserga, Evangelia (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)
      The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are ...