Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent Submissions
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Cell signaling and regulation of smooth muscle contraction from a physiological and a pathophysiological perspective
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-24)The aim of this thesis was to examine the cell signaling and regulation of smooth muscle in different smooth muscle tissues and under pathophysiological conditions. The thesis is based on 4 papers and the experimental ... -
Hepatic 3D spheroids as a model system for drug-induced liver injury and cytochrome P450 induction
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-21)Drug-induced liver injury (DILI) is a major cause of post-marketing drug withdrawals and restricted-use warnings. In addition, unexpected adverse hepatic drug reactions occurring in the clinical phases of development are ... -
Striatal glutamatergic neurotransmission and plasticity in Parkinson's disease and aging
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-15)Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. Affected motor ... -
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-04-12)Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on ... -
Severe trauma : risks and outcomes
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-04-05)Trauma, “the neglected disease of modern society”, is a global health concern of enormous proportions. Knowledge about factors associated with trauma occurrence, complications and outcome is highly valuable for the improvement ... -
Deciphering the interplay between peripheral and central cytokine- and kynurenine pathways : importance for the pathophysiology of schizophrenia
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-03-26)Growing evidence suggests a role of low-grade inflammation in the pathophysiology of schizophrenia, giving rise to a dysregulation in neurons containing dopamine and glutamate as well as γ-aminobutyric acid (GABA). In ... -
Survival and renal function after acute kidney injury : epidemiological and biomarker studies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-01-10)Acute Kidney Injury (AKI) occurs frequently in the critically ill and has an extremely high short-term mortality. The long-term risks of death, Chronic Kidney Disease (CKD) and End Stage Renal Disease (ESRD) have not been ... -
Skeletal muscle plasticity and energy metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-24)Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, ... -
Novel aspects on osmolality and plasma sodium during pregnancy and labour
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-21)This thesis was designed to study causes and effects of changes in plasma sodium and osmolality during pregnancy and labour. The physiological changes of early pregnancy include reduction in plasma sodium ... -
Polycystic ovary syndrome (PCOS) : role of androgens and obesity on placental function and fetal development
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-07)Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women in childbearing age with a prevalence of up to 17.8%. The syndrome is characterized by hyperandrogenism, irregular cycles and ... -
Pathological responses of glial cells in spinal cord injury and rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-02)Scientists have considered glia as mere passive allies of neurons for a long time. As a consequence, their functions have been greatly underestimated. Major discoveries made in the last three decades have changed our ... -
Role of spinal and peripheral HMGB1 in arthritis-induced pain
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-10-03)Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain ... -
Exercise and regulation of metabolic function in human skeletal muscle: with special reference to PGC-1α and the mitochondria
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-04-26)Regular physical activity is highly associated with many health benefits and regular exercise training is used in the prevention and treatment of a large number of disease conditions, including type 2 diabetes, cardiovascular ... -
Molecular aspects of WNT/Frizzled signalling in brain angiogenesis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-04-07)The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate. WNTs induce signalling cascades by binding the seven ... -
The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-03-08)Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These ... -
A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s)
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-02-28)The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, ... -
Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-01-10)Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in ... -
Circadian rhythms in the auditory system
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-12-27)Circadian clocks have been found in numerous cell types and tissues of the body, allowing organisms to coordinate their daily biological functions. They generate cycles of behavioral and physiological processes with a ... -
NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-11)Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of ... -
Aspects on extracorporeal life support for severe acute respiratory failure with special reference to the influenza A/H1N1 2009 pandemic
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-03)Extracorporeal membrane oxygenation provides pulmonary and circulatory support. First abandoned from the majority of the intensive care community because of disappointing results in several trials (with questionable ...