Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent Submissions
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Exercise and regulation of metabolic function in human skeletal muscle: with special reference to PGC-1α and the mitochondria
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-04-26)Regular physical activity is highly associated with many health benefits and regular exercise training is used in the prevention and treatment of a large number of disease conditions, including type 2 diabetes, cardiovascular ... -
Molecular aspects of WNT/Frizzled signalling in brain angiogenesis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-04-07)The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate. WNTs induce signalling cascades by binding the seven ... -
The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-03-08)Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These ... -
A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s)
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-02-28)The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, ... -
Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-01-10)Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in ... -
Circadian rhythms in the auditory system
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-12-27)Circadian clocks have been found in numerous cell types and tissues of the body, allowing organisms to coordinate their daily biological functions. They generate cycles of behavioral and physiological processes with a ... -
NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-11)Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of ... -
Aspects on extracorporeal life support for severe acute respiratory failure with special reference to the influenza A/H1N1 2009 pandemic
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-03)Extracorporeal membrane oxygenation provides pulmonary and circulatory support. First abandoned from the majority of the intensive care community because of disappointing results in several trials (with questionable ... -
Mechanisms of pain in autoimmunity : the role of antibodies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-10-18)Chronic pain in autoimmune diseases, like rheumatoid arthritis (RA), is a common and life- changing problem for many patients. Treatment is usually aimed at reducing inflammation and preserving the function of affected ... -
Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-09-30)Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in ... -
Transcriptional regulation of ribosome biogenesis in skeletal muscle growth
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-30)Resistance exercise induces skeletal muscle hypertrophy via repeated exercise bouts. The increased muscle protein synthesis together with altered muscle protein degradation contribute to the adaptation of muscle mass. The ... -
Neurally adjusted ventilatory assist : from animal studies to clinical practice
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-20)Patients in the Intensive Care Unit (ICU) undergoing ventilator treatment may experience asynchrony with the ventilator, which has been associated with increased need of sedation, sleep disruption, prolonged mechanical ... -
Colon cancer specific cytochrome P450 2W1 : polymorphism, membrane topology and endogenous roles in development
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-19)Cytochrome P450 2W1 (CYP2W1) belongs to a family of drug metabolizing monooxygenases with an unidentified yet endogenous function. CYP2W1 expression pattern has characteristic features of oncofetal genes. Previous studies ... -
Intravenous induction of anaesthesia in children : aspects on propofol and etomidate
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-29)Propofol is today the most commonly used drug for induction of anaesthesia and for short-term sedation. However, one specific problem is that intravenous injection of propofol often results in quite severe injection pain, ... -
Ionic modulators of stem cell state
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-27)Tissue generation during development and maintenance throughout life relies on the proliferation and sequential specification of a group of cells. Stem cells are defined by the properties of self-renewal (division to produce ... -
Chronic pain and arthritis – studies of mechanisms in the regulation of hypersensitivity
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-15)Chronic pain is one of the most devastating symptoms reported by rheumatoid arthritis (RA) patients. Current treatment strategies are focusing on dampening the inflammatory and immunological aspects of RA, but unfortunately ... -
Abnormal coagulation and platelet function in patients with severe traumatic brain injury
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-03-22)Traumatic brain injury (TBI) is associated with a high mortality and severe long-term morbidity in survivors. TBI often affects previously healthy young persons, and represents one of the most common causes of death among ... -
Skin conductance variability and stressful exposures in critical care
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-02-19)Numerous stressors affect the intensive care unit (ICU) patient. The ICU environment is busy and noisy, with monitoring and treatment around the clock. ICU patients may have problems in getting some sleep, due to lighting ... -
Structural and functional analysis of WNT receptors : with emphasis on FZD6
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-12-17)Many cellular processes are dependent on the activation of G protein-coupled receptors (GPCRs). The development of drugs that can specifically target GPCRs and their corresponding signalling cascades is of high interest. ... -
The search for human skeletal muscle memory : exercise effects on the transcriptome and epigenome
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-11-05)Regular physical activity is an environmental stimulus that is highly associated to many health benefits, while physical inactivity is detrimental for health and physical function. Regular exercise training is used in ...