Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent submissions
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Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-17)The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ... -
Brain immune mechanisms in schizophrenia : experimental and clinical characterization
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-19)The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine ... -
Life after intensive care-post-intensive care syndrome, inflammation, and HMGB1
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-17)Survival rates of intensive care unit (ICU) patients are consistently increasing. This new patient population has recently gained increased recognition as they suffer from psychological, physical, and cognitive impairments ... -
Antibody activation of sensory neurons : exploring novel pain mechanisms in rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-11-07)Chronic pain is a worldwide major problem that presents several challenges due to lack of treatment efficacy and/or side effects associated with long-term usage of analgesics. Autoimmune diseases such as rheumatoid ... -
Molecular adaptations of skeletal muscle in health and disease
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-17)Appropriate function of skeletal muscle is essential for locomotion, everyday activities and athletic performance. In addition to its mechanic tasks, skeletal muscle communicates with other organs via metabolic pathways ... -
Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-11)Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently ... -
Not just protein factories : role of ribosome biogenesis as an architect of epithelial-mesenchymal transition and breast cancer progression
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-27)RNA polymerase I (Pol I)-mediated transcription of ribosomal DNA (rDNA) is considered to be the rate-limiting step in ribosome biogenesis and is a well-known hallmark of cell growth and proliferation. The process of ... -
Sickness & behavior in ME/CFS (Chronic Fatigue Syndrome)
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-06)Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic debilitating condition characterized by physical and mental fatigue with a heightened sensitivity to exertion. To date, the causes are ... -
Articular and epiphyseal cartilage : its formation, maintenance and repair
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-08-22)Long bones develop via a series of ordered processes, initiated from mesenchymal stem cell condensation, cartilage anlagen formation, followed by central cell hypertrophy and vascular invasion and the finalized by the ... -
Inter-hospital transports of critically ill children
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-24)There is an increasing need for inter-hospital transports of seriously ill children as a result of centralization of intensive care for children to dedicated pediatric intensive care units (PICU). This thesis has explored ... -
Effects of acute exercise and training on gene expression and regulatory proteins in human skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-20)Regular physical activity affects all tissues in the human body, not least skeletal muscle. The skeletal muscle adaptation involves changes that help the muscle to handle perturbations of the intracellular homeostasis ... -
Novel biomarkers for detection of early acute kidney injury, renal recovery and bacterial infections in critically ill patients
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-03)Diagnosis of infection in the intensive care unit (ICU) is challenging because the signs and symptoms normally attributed to infection are quite common also in ICU patients without infection. This is a problem as delayed ... -
Acute kidney injury : a study of function markers
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-02)Acute Kidney Injury (AKI) is defined as a sudden decrease in the kidneys' ability to filtrate waste products and excrete excess water. Detecting AKI primarily relies on measuring the increased concentration of function ... -
Performance of a revised capnodynamic method for cardiac output monitoring
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-04-25)Cardiac output (CO) monitoring is ideal for guiding fluid, vasopressor and inotropic therapy for sufficient oxygen delivery and may improve outcome in high risk surgery. In this context, many minimally-and non-invasive ... -
Body posture and gravity as determinants of lung perfusion and ventilation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-04-01)Normal lung gas exchange depends on an intimate match between regional ventilation and regional blood flow in the lungs. The beneficial effect of the prone posture in acute respiratory failure is well documented but the ... -
Life after extracorporeal membrane oxygenation : long-term survival and quality of life
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-03-07)Background: The use of Extracorporeal membrane oxygenation (ECMO) has steadily increased in the last decades and has evolved in several ways. From originally being a means to support the neonatal patient with respiratory ... -
Capnodynamic determination of effective pulmonary blood flow and end expiratory lung volume : studies in children and paediatric animal models
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-03-06)Dynamic capnography is a haemodynamic and respiratory monitoring technique enabling continuous cardiac output (Effective Pulmonary Blood Flow, COEPBF) and end expiratory lung volume (Effective Lung Volume, ELV) assessment in ... -
The role of SUMO pathway in pathophsiology of skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-01-17)Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino ... -
Activation mechanisms of Class F receptors
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-12-12)Our genetic makeup is composed of thousands of genes that code for the proteins involved in all aspects of cellular function. Proteins are molecular machines that dynamically and structurally respond to stimuli. Cells ... -
Sinomenine as a novel analgesic : mechanisms and applications
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-11-26)Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of ...