Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent submissions
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Perioperative management and molecular patterns in patients with obstructive sleep apnea
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-20)Obstructive sleep apnea (OSA) is a common disorder, both in the general and surgical population. While there is a steadily increased awareness of the disorder both in the society as a whole and within health care, ... -
Novel skeletal stem and progenitor cells and their regulation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-20)The development of bone and cartilage, which provide the framework of the skeletal system, is complex. In this context stem and progenitor cells play a crucial role by producing differentiated cells. Hormones are important ... -
Aspects of risk factors, pathophysiology and outcomes in trauma
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-14)Trauma is a global health concern. Many trauma patients succumb on the scene or in the immediate phase after trauma. Patients surviving the initial phase may die at a later stage or suffer debilitating consequences in ... -
Modelling of steatosis and insulin resistance development in human hepatic 3d spheroids : mechanisms and genetic aspects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-10)Hepatic steatosis and insulin resistance are common disease manifestations seen in metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) patients. Aberrant hepatic lipid accumulation leads ... -
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-11-09)Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over ... -
Assessing the importance of rare genetic variants for drug response
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-27)Inter-individual variability in drug response is commonly observed in pharmacological treatment, resulting in 40-70% of patients suffering from low drug efficacy or adverse drug reactions. These negative ... -
Long-term outcomes after trauma and intensive care
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-25)The goals of trauma and critical care are twofold: to prevent short- and long-term mortality and to return the patient to an independent life. With the development of modern trauma care including technical advancements ... -
WNT/Frizzled signaling : illuminating the road towards pathway selectivity
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-10-21)Cells sense and respond to their environment via receptors embedded in the plasma membrane. Receptors allow flow of information from outside to the inside of the cell and are generally regulated by extracellular molecules ... -
Mechanisms of inter-organ crosstalk mediated by tryptophan metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-09-28)Physical exercise and nutrition balance the “energy in-energy out” equilibrium that keeps the system at a dynamic homeostasis, energetically speaking. However, this is a simplistic vision of a dynamic system that is in ... -
Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-26)Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles ... -
Sex and gender aspects on intensive care : access, intensity and outcome
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-06)There is an underlying assumption in society that critically ill patients are admitted to an intensive care unit (ICU) based on their illness severity coupled with their comorbidities, and that other variables are ... -
The kynurenine pathway in body and brain : relation with physical exercise and mental health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-04-29)The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better ... -
Prediction of psychological and physical morbidity after critical illness and intensive care unit stay
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-01-11)A large proportion of survivors of critical illness and intensive care unit stay suffer from post- intensive care syndrome (PICS), consisting of psychological, physical and cognitive problems. These problems can persist ... -
Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. ... -
From brain to muscle and back : novel approaches to harness the benefits of exercise
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)As the world population is growing older and more sedentary every day, the need for new approaches to combat chronic diseases grows steadily. Physical exercise improves health and reduces the risk of developing a plethora ... -
Perioperative risk factors and outcomes
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-24)Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ... -
MRI sequences for detection of acute pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-19)In recent years a range of imaging techniques have emerged to help diagnose patients with suspected acute Pulmonary Embolism (PE). This is particularly useful for those who are contraindicated (renal failure or allergies) ... -
Facilitating precision medicine through analysis of next-generation sequencing projects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-18)Precision medicine constitutes an emerging strategy that aims at the individualization of healthcare by considering the personal molecular features and environmental factors of the patient in question. Genetic biomarkers ... -
Dietary nitrate and the microbiota : modulators of metabolic function
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-12)Nitric oxide (NO) deficiency represents a known feature of cardiovascular and metabolic diseases as well as natural aging. The NO metabolites nitrate and nitrite have long been considered as health-threatening food components ... -
SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-25)The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an ...