Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent submissions
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SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-25)The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an ... -
Exercise-induced molecular mechanisms in untrained and life-long highly trained individuals
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-21)Regular physical activity results in extensive systemic and functional adaptation effects in the human body that contribute to physical performance, such as muscular strength and endurance, and can have beneficial health ... -
Current diagnostic aspects on acute and chronic pulmonary embolism : MRI in acute pulmonary embolism, CT in chronic thromboembolic pulmonary hypertension and what the radiologists actually know
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ... -
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-17)The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ... -
The role of dietary nitrate in regulation of blood pressure and metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)A diet rich in vegetables is recommended for health in general and is also associated with lower blood pressure. Research suggests that inorganic nitrate present in leafy green vegetables could be a contributing factor ... -
Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are ... -
Oxidative stress and muscle weakness associated with rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-31)Muscle weakness is a common comorbidity of several severe diseases which results in a reduced independence and quality of life and for the afflicted patients. For instance, patients with rheumatoid arthritis (RA), a ... -
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-17)The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ... -
Brain immune mechanisms in schizophrenia : experimental and clinical characterization
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-19)The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine ... -
Life after intensive care-post : intensive care syndrome, inflammation, and HMGB1
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-17)Survival rates of intensive care unit (ICU) patients are consistently increasing. This new patient population has recently gained increased recognition as they suffer from psychological, physical, and cognitive impairments ... -
Antibody activation of sensory neurons : exploring novel pain mechanisms in rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-11-07)Chronic pain is a worldwide major problem that presents several challenges due to lack of treatment efficacy and/or side effects associated with long-term usage of analgesics. Autoimmune diseases such as rheumatoid ... -
Molecular adaptations of skeletal muscle in health and disease
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-17)Appropriate function of skeletal muscle is essential for locomotion, everyday activities and athletic performance. In addition to its mechanic tasks, skeletal muscle communicates with other organs via metabolic pathways ... -
Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-11)Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently ... -
Not just protein factories : role of ribosome biogenesis as an architect of epithelial-mesenchymal transition and breast cancer progression
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-27)RNA polymerase I (Pol I)-mediated transcription of ribosomal DNA (rDNA) is considered to be the rate-limiting step in ribosome biogenesis and is a well-known hallmark of cell growth and proliferation. The process of ... -
Sickness & behavior in ME/CFS (Chronic Fatigue Syndrome)
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-06)Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic debilitating condition characterized by physical and mental fatigue with a heightened sensitivity to exertion. To date, the causes are ... -
Articular and epiphyseal cartilage : its formation, maintenance and repair
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-08-22)Long bones develop via a series of ordered processes, initiated from mesenchymal stem cell condensation, cartilage anlagen formation, followed by central cell hypertrophy and vascular invasion and the finalized by the ... -
Inter-hospital transports of critically ill children
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-24)There is an increasing need for inter-hospital transports of seriously ill children as a result of centralization of intensive care for children to dedicated pediatric intensive care units (PICU). This thesis has explored ... -
Effects of acute exercise and training on gene expression and regulatory proteins in human skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-20)Regular physical activity affects all tissues in the human body, not least skeletal muscle. The skeletal muscle adaptation involves changes that help the muscle to handle perturbations of the intracellular homeostasis ... -
Novel biomarkers for detection of early acute kidney injury, renal recovery and bacterial infections in critically ill patients
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-03)Diagnosis of infection in the intensive care unit (ICU) is challenging because the signs and symptoms normally attributed to infection are quite common also in ICU patients without infection. This is a problem as delayed ... -
Acute kidney injury : a study of function markers
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-02)Acute Kidney Injury (AKI) is defined as a sudden decrease in the kidneys' ability to filtrate waste products and excrete excess water. Detecting AKI primarily relies on measuring the increased concentration of function ...