Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent submissions
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Mechanisms of inter-organ crosstalk mediated by tryptophan metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-09-28)Physical exercise and nutrition balance the “energy in-energy out” equilibrium that keeps the system at a dynamic homeostasis, energetically speaking. However, this is a simplistic vision of a dynamic system that is in ... -
Pain in rheumatoid arthritis : bone and neuroinflammation-associated mechanisms
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-26)Pain is often the primary reason patients with rheumatoid arthritis (RA) seek medical care. Despite effective disease control with currently available disease modifying antirheumatic drugs (DMARDs), there are still hurdles ... -
Sex and gender aspects on intensive care : access, intensity and outcome
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-05-06)There is an underlying assumption in society that critically ill patients are admitted to an intensive care unit (ICU) based on their illness severity coupled with their comorbidities, and that other variables are ... -
The kynurenine pathway in body and brain : relation with physical exercise and mental health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-04-29)The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better ... -
Prediction of psychological and physical morbidity after critical illness and intensive care unit stay
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-01-11)A large proportion of survivors of critical illness and intensive care unit stay suffer from post- intensive care syndrome (PICS), consisting of psychological, physical and cognitive problems. These problems can persist ... -
Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. ... -
From brain to muscle and back : novel approaches to harness the benefits of exercise
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)As the world population is growing older and more sedentary every day, the need for new approaches to combat chronic diseases grows steadily. Physical exercise improves health and reduces the risk of developing a plethora ... -
Perioperative risk factors and outcomes
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-24)Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ... -
MRI sequences for detection of acute pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-19)In recent years a range of imaging techniques have emerged to help diagnose patients with suspected acute Pulmonary Embolism (PE). This is particularly useful for those who are contraindicated (renal failure or allergies) ... -
Facilitating precision medicine through analysis of next-generation sequencing projects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-18)Precision medicine constitutes an emerging strategy that aims at the individualization of healthcare by considering the personal molecular features and environmental factors of the patient in question. Genetic biomarkers ... -
Dietary nitrate and the microbiota : modulators of metabolic function
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-12)Nitric oxide (NO) deficiency represents a known feature of cardiovascular and metabolic diseases as well as natural aging. The NO metabolites nitrate and nitrite have long been considered as health-threatening food components ... -
SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-25)The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an ... -
Exercise-induced molecular mechanisms in untrained and life-long highly trained individuals
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-08-21)Regular physical activity results in extensive systemic and functional adaptation effects in the human body that contribute to physical performance, such as muscular strength and endurance, and can have beneficial health ... -
Current diagnostic aspects on acute and chronic pulmonary embolism : MRI in acute pulmonary embolism, CT in chronic thromboembolic pulmonary hypertension and what the radiologists actually know
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ... -
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-17)The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ... -
The role of dietary nitrate in regulation of blood pressure and metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)A diet rich in vegetables is recommended for health in general and is also associated with lower blood pressure. Research suggests that inorganic nitrate present in leafy green vegetables could be a contributing factor ... -
Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are ... -
Oxidative stress and muscle weakness associated with rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-31)Muscle weakness is a common comorbidity of several severe diseases which results in a reduced independence and quality of life and for the afflicted patients. For instance, patients with rheumatoid arthritis (RA), a ... -
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-17)The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ... -
Brain immune mechanisms in schizophrenia : experimental and clinical characterization
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-19)The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine ...