Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Inter-hospital transports of critically ill children
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-24)There is an increasing need for inter-hospital transports of seriously ill children as a result of centralization of intensive care for children to dedicated pediatric intensive care units (PICU). This thesis has explored ... -
Effects of acute exercise and training on gene expression and regulatory proteins in human skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-20)Regular physical activity affects all tissues in the human body, not least skeletal muscle. The skeletal muscle adaptation involves changes that help the muscle to handle perturbations of the intracellular homeostasis ... -
Novel biomarkers for detection of early acute kidney injury, renal recovery and bacterial infections in critically ill patients
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-03)Diagnosis of infection in the intensive care unit (ICU) is challenging because the signs and symptoms normally attributed to infection are quite common also in ICU patients without infection. This is a problem as delayed ... -
Acute kidney injury : a study of function markers
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-02)Acute Kidney Injury (AKI) is defined as a sudden decrease in the kidneys' ability to filtrate waste products and excrete excess water. Detecting AKI primarily relies on measuring the increased concentration of function ... -
Performance of a capnodynamic method for cardiac output monitoring
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-04-25)Cardiac output (CO) monitoring is ideal for guiding fluid, vasopressor and inotropic therapy for sufficient oxygen delivery and may improve outcome in high risk surgery. In this context, many minimally-and non-invasive ... -
Body posture and gravity as determinants of lung perfusion and ventilation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-04-01)Normal lung gas exchange depends on an intimate match between regional ventilation and regional blood flow in the lungs. The beneficial effect of the prone posture in acute respiratory failure is well documented but the ... -
Life after extracorporeal membrane oxygenation : long-term survival and quality of life
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-03-07)Background: The use of Extracorporeal membrane oxygenation (ECMO) has steadily increased in the last decades and has evolved in several ways. From originally being a means to support the neonatal patient with respiratory ... -
Capnodynamic determination of effective pulmonary blood flow and end expiratory lung volume : studies in children and paediatric animal models
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-03-06)Dynamic capnography is a haemodynamic and respiratory monitoring technique enabling continuous cardiac output (Effective Pulmonary Blood Flow, COEPBF) and end expiratory lung volume (Effective Lung Volume, ELV) assessment in ... -
The role of SUMO pathway in pathophsiology of skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-01-17)Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino ... -
Activation mechanisms of Class F receptors
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-12-12)Our genetic makeup is composed of thousands of genes that code for the proteins involved in all aspects of cellular function. Proteins are molecular machines that dynamically and structurally respond to stimuli. Cells ... -
Sinomenine as a novel analgesic : mechanisms and applications
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-11-26)Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of ... -
Novel insights into dishevelled and frizzled function
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-18)The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling ... -
Environmental regulation of metabolism : from transgenerational effects of nutrition to acute effects of exercise
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-08)The incidence of metabolic disease has risen rapidly in the last half-century leading to both individual suffering and a burden to society. The importance of physical activity for metabolic health is well known. Furthermore, ... -
High-intensity interval training in combination with aerobic or resistance training for patients with breast cancer : a HIIT to counteract detrimental effects of chemotherapy
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-09)With the increasing number of individuals that enter cancer survivorship there is a growing need for interventions that can alleviate treatment-related adverse effects such as fatigue, and that can improve and restore ... -
Structure and function relationships in the PGC-1 family of transcriptional coactivators
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-08)PGC-1 coactivators are central regulators of several cellular processes, most notably the coupling between energy demands and supply. PGCs activate distinct biological processes in a tissue-specific manner. These include ... -
Critical illness myopathy : mechanisms and pharmacological interventions
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-02)The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and ... -
Cell signaling and regulation of smooth muscle contraction from a physiological and a pathophysiological perspective
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-24)The aim of this thesis was to examine the cell signaling and regulation of smooth muscle in different smooth muscle tissues and under pathophysiological conditions. The thesis is based on 4 papers and the experimental ... -
Hepatic 3D spheroids as a model system for drug-induced liver injury and cytochrome P450 induction
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-21)Drug-induced liver injury (DILI) is a major cause of post-marketing drug withdrawals and restricted-use warnings. In addition, unexpected adverse hepatic drug reactions occurring in the clinical phases of development are ... -
Striatal glutamatergic neurotransmission and plasticity in Parkinson's disease and aging
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-15)Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. Affected motor ... -
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-04-12)Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on ...