Doktorsavhandlingar / Doctoral Theses - C3 (FyFa)
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Recent Submissions
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The role of SUMO pathway in pathophsiology of skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-01-17)Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino ... -
Activation mechanisms of Class F receptors
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-12-12)Our genetic makeup is composed of thousands of genes that code for the proteins involved in all aspects of cellular function. Proteins are molecular machines that dynamically and structurally respond to stimuli. Cells ... -
Sinomenine as a novel analgesic : mechanisms and applications
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-11-26)Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of ... -
Novel insights into dishevelled and frizzled function
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-18)The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling ... -
Environmental regulation of metabolism : from transgenerational effects of nutrition to acute effects of exercise
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-08)The incidence of metabolic disease has risen rapidly in the last half-century leading to both individual suffering and a burden to society. The importance of physical activity for metabolic health is well known. Furthermore, ... -
High-intensity interval training in combination with aerobic or resistance training for patients with breast cancer : a HIIT to counteract detrimental effects of chemotherapy
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-09)With the increasing number of individuals that enter cancer survivorship there is a growing need for interventions that can alleviate treatment-related adverse effects such as fatigue, and that can improve and restore ... -
Structure and function relationships in the PGC-1 family of transcriptional coactivators
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-08)PGC-1 coactivators are central regulators of several cellular processes, most notably the coupling between energy demands and supply. PGCs activate distinct biological processes in a tissue-specific manner. These include ... -
Critical illness myopathy : mechanisms and pharmacological interventions
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-02)The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and ... -
Cell signaling and regulation of smooth muscle contraction from a physiological and a pathophysiological perspective
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-24)The aim of this thesis was to examine the cell signaling and regulation of smooth muscle in different smooth muscle tissues and under pathophysiological conditions. The thesis is based on 4 papers and the experimental ... -
Hepatic 3D spheroids as a model system for drug-induced liver injury and cytochrome P450 induction
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-21)Drug-induced liver injury (DILI) is a major cause of post-marketing drug withdrawals and restricted-use warnings. In addition, unexpected adverse hepatic drug reactions occurring in the clinical phases of development are ... -
Striatal glutamatergic neurotransmission and plasticity in Parkinson's disease and aging
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-15)Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. Affected motor ... -
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-04-12)Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on ... -
Severe trauma : risks and outcomes
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-04-05)Trauma, “the neglected disease of modern society”, is a global health concern of enormous proportions. Knowledge about factors associated with trauma occurrence, complications and outcome is highly valuable for the improvement ... -
Deciphering the interplay between peripheral and central cytokine- and kynurenine pathways : importance for the pathophysiology of schizophrenia
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-03-26)Growing evidence suggests a role of low-grade inflammation in the pathophysiology of schizophrenia, giving rise to a dysregulation in neurons containing dopamine and glutamate as well as γ-aminobutyric acid (GABA). In ... -
Survival and renal function after acute kidney injury : epidemiological and biomarker studies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-01-10)Acute Kidney Injury (AKI) occurs frequently in the critically ill and has an extremely high short-term mortality. The long-term risks of death, Chronic Kidney Disease (CKD) and End Stage Renal Disease (ESRD) have not been ... -
Skeletal muscle plasticity and energy metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-24)Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, ... -
Novel aspects on osmolality and plasma sodium during pregnancy and labour
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-21)This thesis was designed to study causes and effects of changes in plasma sodium and osmolality during pregnancy and labour. The physiological changes of early pregnancy include reduction in plasma sodium ... -
Polycystic ovary syndrome (PCOS) : role of androgens and obesity on placental function and fetal development
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-07)Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women in childbearing age with a prevalence of up to 17.8%. The syndrome is characterized by hyperandrogenism, irregular cycles and ... -
Pathological responses of glial cells in spinal cord injury and rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-02)Scientists have considered glia as mere passive allies of neurons for a long time. As a consequence, their functions have been greatly underestimated. Major discoveries made in the last three decades have changed our ... -
Role of spinal and peripheral HMGB1 in arthritis-induced pain
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-10-03)Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain ...