Now showing items 1-20 of 496

    • p53-dependent and -independent mechanisms of p53-targeting small molecules 

      Zhu, Jiawei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-03-05)
      Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...
    • Dihydroorotate dehydrogenase : new insights into an old target 

      Popova, Gergana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-01-24)
      Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. ...
    • Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision 

      Mollick, Tanzina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-27)
      Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ...
    • Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases 

      Sendel, Anton (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-18)
      The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...
    • Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific b cell responses 

      Vázquez Bernat, Néstor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-21)
      Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most ...
    • Bacterial communities and antibiotic resistance in human-impacted water environments 

      Guzman Otazo, Carol Jessica (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-07)
      From a One-Health concept the health of humans, animals and the environment is interconnected and what happens to one of the domains will affect the other two simultaneously. This concept can be applied not only to the ...
    • Revealing the secrets of MARCO : a target for cancer immunotherapy 

      Eisinger, Silke (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-06)
      Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. ...
    • Exploring B cell responses in Plasmodium falciparum malaria 

      Rönnberg, Caroline (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-10-18)
      Plasmodium falciparum malaria remains one of the most devastating infectious diseases today. Small children in sub-Saharan Africa carry the heaviest burden of morbidity and mortality. Immunity to malaria is not well ...
    • Alphavirus-host interactions : how to unravel the proviral activity of G3BP 

      Götte, Benjamin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-30)
      The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically ...
    • Relation between nutritional status, the outcome of infection and immune responses 

      Terán, Graciela (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-16)
      A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and ...
    • Effects of DNA damage and vesicular exchange in P. falciparum 

      Hjelmqvist, Daisy (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-28)
      Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
    • Identification and characterization of small molecules targeting MYC function 

      Yan, Qinzi (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-21)
      The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role ...
    • Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway 

      Liu, Lifeng (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-03)
      As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular ...
    • Decoding the tumor microenvironment : a B-cell and Macrophage perspective 

      Boura, Vanessa F. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-02)
      The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this ...
    • Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer 

      Zhang, Fan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-26)
      Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes ...
    • Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions 

      Nabar, Neel R. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-14)
      The ability to generate a robust immune response is integral to organismal homeostasis. Cells of the innate immune system are considered the first responders of immunity, and are therefore responsible for sensing both ...
    • Cooperativity between MYC and other oncogenic factors : implications for tumorigenesis and targeting of MYC 

      Zakaria, Siti Mariam (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-08)
      Normal cell homeostasis in a tissue requires a delicate balance between cell growth, maintenance and death, tightly controlled by an intricate interplay between proto-oncogenes and tumor suppressor genes. When the balance ...
    • Developing new models of childhood malignancies using human induced pluripotent stem cells 

      Marin Navarro, Ana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)
      Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the usefulness of ...
    • The role of growth factors in white fat browning and metabolic disease 

      Fischer, Carina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-01-16)
      The adipose tissue is composed of a variety of cell types that constantly cross-communicate with each other to allow the tissue to operate and to adapt to various external stimuli. The diversity of these cell populations ...
    • The functional impact of gut microbiota on CNS regulation of local and systemic homeostasis 

      Abbaspour, Afrouz (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-08-24)
      The “gut microbiota” is widely accepted as an integral part of the gut homeostasis, and is thought to contribute to the establishment of intestinal barrier. Growing body of research suggest that the influence of gut ...