Now showing items 1-20 of 512

    • Learning from primary immunodeficiencies to treat cancer 

      Oliveira, Mariana M. S. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-09)
      The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ...
    • Hfq- and sRNA-mediated regulation in Neisseria meningitidis 

      Karlsson, Jens (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-03)
      Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal ...
    • Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance 

      Moyano Galceran, Lidia (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-08-09)
      Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully ...
    • Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation 

      Bazzar, Wesam (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-27)
      Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. ...
    • RNA-mediated gene regulation in Neisseria meningitidis and other nasopharyngeal pathogens 

      Eichner, Hannes (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-07)
      Neisseria meningitidis is a transient commensal bacterium of the upper respiratory tract and spreads through respiratory secretions produced by the carrier. While mostly harmless, the bacterium can cause invasive meningococcal ...
    • Pattern recognition and iNKT cell regulation of B cell activation 

      He, Chenfei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-05)
      The immune system protects individuals against infections but can cause disease if the response is unbalanced. Immune responses include both innate and adaptive response, and these systems are connected. As the first line ...
    • The role of oestrogens and antibiotics on the development of cancer 

      Simin, Johanna (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-04-29)
      Despite advances in cancer treatment and surgery, cancer-related mortality remains the leading cause of death globally, harvesting over ten million lives annually. While the risk factors are both hormonal and non-hormonal, ...
    • Adaptation of Salmonella enterica to antibiotics and innate immunity effectors 

      Vestö, Kim (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-02-22)
      Salmonella enterica is a bacterial pathogen causing major morbidity and mortality in low- and middle-income countries. The bacteria can cause a wide range of disease, ranging from the severe systemic disease typhoid fever ...
    • Targeting cell envelope synthesis of Streptococcus pneumoniae and microfluidic diagnostic tool development 

      Reithuber, Elisabeth (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-01-25)
      Evolving antibiotic resistance warrants the development of new therapeutic and diagnostic approaches as part of the strategies to secure future antibacterial therapies and preserve the compounds currently available. Work ...
    • Investigating the role of p73 proteins in controlling the tumor microenvironment 

      Wolfsberger, Johanna (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-10-20)
      Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
    • Effects of intestinal worms on skin immunity and control of co-infection 

      Classon, Cajsa (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-08-21)
      Intestinal helminth infections remain a major health concern in developing areas of the world. Consequences of infection range from gastrointestinal discomfort to systemic manifestations. It has been suggested that ...
    • Characterization of B cell response alterations resulting from ablation of IκBNS expression 

      Khoenkhoen, Sharesta (C1, MTC, 2020-08-07)
      The immune system is a sophisticated organization of cells and tissues that cooperate in safeguarding the integrity of our body by eliminating internal and external threats. Vaccines are the most impactful medical intervention ...
    • A study on the role of T helper cells in allergic inflammation 

      Stark, Julian Mario (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-26)
      Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through ...
    • FtsH protease and ClpG disaggregase confer fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C 

      Kamal, Shady Mansour (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-20)
      Pseudomonas aeruginosa is an environmental bacterium and a frequent nosocomial pathogen causing a wide range of opportunistic infections, especially in immunocompromised patients. Clone C is one of the most prevalent ...
    • Competence pilus biogenesis in Streptococcus pneumoniae 

      Oliveira, Vitor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-08)
      Horizontal gene transfer drives bacterial evolution and is crucial for the pathogenicity of many bacteria that can exchange genetic material through distinct mechanisms such as natural transformation. S. pneumoniae, a ...
    • Diverse cyclic dinucleotide signals regulate Escherichia coli lifestyle transition 

      Li, Fengyang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-04-29)
      Bacteria have the ability to change their lifestyle to adapt to various environmental conditions. Cyclic dinucleotides (cDNs) are ubiquitous second messengers that can regulate fundamental lifestyle switches, such as ...
    • p53-dependent and -independent mechanisms of p53-targeting small molecules 

      Zhu, Jiawei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-03-05)
      Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...
    • Dihydroorotate dehydrogenase : new insights into an old target 

      Popova, Gergana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-01-24)
      Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. ...
    • Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision 

      Mollick, Tanzina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-27)
      Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ...
    • Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases 

      Sendel, Anton (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-18)
      The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...