Publications from KI: Recent submissions
Now showing items 81-100 of 10115
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Innovations in pancreatology
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-26)In paper I, we explored the presence and potential significance of intracystic pancreatic microbiomes in patients with suspected pancreatic cystic neoplasms (PCNs), who underwent pancreatic surgery. Paired samples of ... -
Race against time : performance of emergency medical dispatch centres in out-of-hospital cardiac arrest
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-04-26)Background: Out-of-hospital cardiac arrest (OHCA) is an acute medical condition where the heart suddenly stops beating, thus causing blood circulation to cease in the body with irreversible brain damage and death if not ... -
Exploring cannabinoids for indolent B-cell lymphomas
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-26)The overexpression of cannabinoid receptors is well described in several indolent lymphomas but the relevance of this finding is more uncertain. Our group has previously shown that mantle cell lymphoma (MCL)-derived cell ... -
Advancements in detection of performance enhancing drugs in dried blood spots : focusing on erythropoietin
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-26)The use of erythropoietin (EPO) for performance enhancing purposes is detected mainly in urine and serum samples in anti-doping laboratories. However, dried blood spots (DBS) have emerged as a potential additional sample ... -
DNA tools for imaging and manipulation of biological samples
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-26)Spatial organization within biological systems is important for understanding mechanisms underlying health and disease. This thesis investigates the role of spatial distribution at cellular and molecular levels, utilizing ... -
Multiple sclerosis, viruses, and B cell depleting therapy : a meeting at the immune system
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-25)Multiple sclerosis (MS) is a highly heterogeneous disease with a complex and undiscovered etiology. Two of the strongest established risk factors for developing MS are carriage of the HLA-DRB1*15:01 allele and Epstein-Barr ... -
The motives and ethical justifiability of treating patients with borderline personality disorder under compulsory care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-04-25)This thesis aims to investigate what motives psychiatrists have for detaining patients with BPD under compulsory care. Also, to examine hospital staff’s experiences of treating patients with BPD under involuntary care and ... -
High-capacity in vitro models for the assessment of pain-related mechanisms
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-04-25)Chronic pain affects one in five people. Yet, new efficient drugs with fewer adverse effects remain an unmet need for chronic pain. In vitro models that closer recapitulate relevant disease mechanisms are suggested as a ... -
Health consequences of gender-based harassment at work
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-25)Background: Experiences at work with gender-based violence and harassment (GBVH) from superiors, co-workers or third parties are common. This includes a range of verbal or physical behaviors that can be of a sexual nature ... -
From autoimmunity to inflamed joints : study of risk factors, mediators and cellular targets in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-24)Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting mainly the joints and leading to disability. Circulating antibodies against citrullinated proteins (ACPA) are present in the majority of patients and are ... -
Impact of childhood leukemia and its treatment on Nordic children and families : the consent process, toxicity, and quality of life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-24)Background: The survival rate in acute lymphoblastic leukemia (ALL) has improved remarkably over the last half-century and is now reaching above 90%. The treatment is lengthy, however, and with a high risk of short- and ... -
Scare or care? How immunological processes shape perception of sickness-relevant stimuli in humans
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-23)Humans and other animals have developed several defense systems to handle living in a pathogen-rich world. These defense systems include immune responses, as well as behavioral responses aimed at supporting immune functions ... -
Primary cilia in human neuron differentiation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-04-23)Primary (non-motile) cilia have long been overlooked, considered vestigial organelles lacking specific functions. In humans, all cell types except sperm, ependymal and bronchial epithelial cells, and oviduct cells extend ... -
Risk factors for colorectal cancer and the impact on life in lynch syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-23)Colorectal cancer (CRC) constitutes the third most common cancer in Sweden. Approximately 2-4% of CRC cases have a pathogenic variant in a gene known to cause an inherited risk of CRC. The most common hereditary CRC syndrome, ... -
Developing an embryonic stem cell-based cell product for age-related macular degeneration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-22)Age-related macular degeneration (AMD) remains a major cause of blindness with no current cure. With the increasing ageing population in the developed world, a high number of AMD patients is expected. AMD can be distinguished ... -
Exploring T cell mediated immunotherapy against therapy resistant leukemic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-19)The cancer stem cell (CSC) model suggests that cancers depend on continuous replenishment from rare and distinct CSCs, but their existence has been challenging to prove for many malignancies. The CSCs in myeloid leukemias, ... -
Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ... -
Infections, antibiotics, tobacco, genetic factors and risk of lada : latent autoimmune diabetes in adults, and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-17)Diabetes is a spectrum of chronic diseases characterized by hyperglycaemia. The aetiology and pathogenesis differ between types of diabetes, but all can lead to severe complications. Latent autoimmune diabetes in adults ... -
Immediate skin-to-skin contact after a very preterm birth : supporting the parent-infant relationship
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-16)Background: Preterm birth poses challenges that may negatively affect parental mental health and infant development. A well-functioning parent-infant relationship can mitigate the risk of preterm birth on infant development, ...