Publications from KI: Recent submissions

Now showing items 81-100 of 10049

    • Regulation of mtDNA gene expression and the role of respiratory chain supercomplexes in mammalian mitochondria 

      Misic, Jelena (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)
      Mitochondria are cellular organelles found in nearly all eukaryotic cells, where they fulfill a plethora of functions, including energy conversion. They harness energy from carbon sources to synthesize adenosine triphosphate ...

    • Mechanisms driving notch disorders and therapeutic implications 

      Iqbal, Afshan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-02-21)
      Biliary tree is an intricate tubular structure lined by cholangiocytes or biliary epithelial cells. The differentiation, development and morphogenesis of bile ducts is controlled by Notch signaling and other pathways. ...

    • Gestational weight gain, bariatric surgery, and adverse maternal and infant outcomes 

      Xu, Huiling (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-20)
      Gestational weight gain is a crucial predictor for various adverse maternal and infant outcomes. In 2009, the U.S. Institute of Medicine (IOM) introduced optimal ranges for gestational weight gain based on a woman's ...

    • Prognostication in heart failure across the ejection fraction spectrum : implications for clinical practice and trial design 

      Lindberg, Felix (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-19)
      Background. The heterogeneity of heart failure (HF) across the ejection fraction (EF) spectrum presents a challenge when triaging for follow-up, implementing therapies, and designing trials. There is a preconceived notion ...

    • Development of novel and accessible treatments for trichotillomania and skin-picking disorder 

      Asplund, Mia (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-15)
      Background: Trichotillomania (TTM) and Skin-picking disorder (SPD) are psychiatric conditions characterized by recurrent and excessive hair-pulling and skin-picking, respectively. These behaviors result in significant hair ...

    • Defining human adaptive immune gene diversity 

      Narang, Sanjana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-02-15)
      The lymphocytes (B and T cells) of the adaptive immune system undergo variable (V), diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen receptor repertoires capable of recognizing a ...

    • Reproductive and lifestyle risk factors for sarcoidosis 

      Dehara, Marina (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-14)
      Sarcoidosis is a systemic inflammatory condition with an unknown origin, characterized by the formation of granulomatous lesions primarily in the lungs and lymphatic system. Despite over a century since it was first ...

    • The cellular thermal shift assay (CETSA) for elucidating drug mechanism of action and resistance in cancer 

      Bacanu, Smaranda (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-14)
      A complete understanding over drug mechanism of action (MoA) is important when attempting to predict treatment outcome or the presence of resistance in patients. Despite decades of scientific efforts, the MoAs of even some ...

    • Determinants of age-related brain iron accumulation and links to neurocognitive functions 

      Gustavsson, Jonatan (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-02-14)
      Iron is crucial for development and normal functioning of the brain. With increasing age, it accumulates in the cells and can cause irreparable damage, affecting both the structure and function of the brain. Despite these ...

    • Am I mad, bad or dangerous? A novel intervention approach for unwanted intrusive thoughts 

      Olofsdotter Lauri, Klara (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-14)
      Background: Unwanted intrusive thoughts (UITs) containing unacceptable and taboo themes is regarded as a common and, for most, transient cognitive phenomenon. However, these thoughts can become so frequent and distressing ...

    • Consumer reported digital immunization records : feasibility, applicability, and public health utility in the Canadian context 

      Atkinson, Katherine M (Inst för global folkhälsa / Dept of Global Public Health, 2024-02-13)
      Background: Vaccination is one of the most effective public health interventions of all time. Public health programs collect data on Vaccination Coverage (VC) to determine levels of protection and guide resource allocation ...

    • Parkinson's disease and Gaucher disease : focus on the GBA1 link 

      Brodin, Lovisa (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-13)
      Parkinson’s disease (PD) is the 2nd most common neurodegenerative disorder in the world, characterized by both motor as well as many non-motor features. There are many symptomatic treatments available, that may shift ...

    • Enhancing the efficiency of viral and non-viral gene delivery vectors 

      Bazaz, Safa (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-02-13)
      Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. ...

    • Does online parent training measure up to group parent training in real-world settings? 

      Engelbrektsson, Johanna (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-12)
      Background: Disruptive behavior problems involve recurrent patterns of defiance, aggression, and hostility that interfere with normal functioning. Disruptive behaviors are commonly observed in children and adolescents and ...

    • Targeting the ovary : mapping mechanisms to link endocrine-disrupting chemicals to female fertility 

      Li, Tianyi (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-09)
      In recent decades, growing attention has been paid to endocrine-disrupting chemicals (EDCs) as mounting evidence suggests that they can cause detrimental reproductive outcomes in animals and humans. Even though epidemiological ...

    • The efficacy of continuous peripheral blocks after cardiothoracic surgery as evaluated by opioid use, pain, and recovery 

      Larsson, Mark (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-09)
      Pain after cardiothoracic surgery is most intense the first postoperative days and for the most part mild to moderate. International guidelines recommend a multimodal analgesic strategy that includes local anesthetics for ...

    • Standardization of antigen-emulsion preparations for the induction of autoimmune disease models 

      Topping, Louise M; Romero-Castillo, Laura; Urbonaviciute, Vilma; Bolinsson, Hans; Clanchy, Felix I; Holmdahl, Rikard; Bäckström, B Thomas; Williams, Richard O (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-09)
      Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models, and the ...

    • Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice 

      Aoun, Mike; Coelho, Ana; Krämer, Alexander; Saxena, Amit; Sabatier, Pierre; Beusch, Christian Michel; Lönnblom, Erik; Geng, Manman; Do, Nhu-Nguyen; Xu, Zhongwei; Zhang, Jingdian; He, Yibo; Romero Castillo, Laura; Abolhassani, Hassan; Xu, Bingze; Viljanen, Johan; Rorbach, Joanna; Fernandez Lahore, Gonzalo; Gjertsson, Inger; Kastbom, Alf; Sjöwall, Christopher; Kihlberg, Jan; Zubarev, Roman A; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
      B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, ...

    • Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis 

      Urbonaviciute, Vilma; Romero-Castillo, Laura; Xu, Bingze; Luo, Huqiao; Schneider, Nadine; Weisse, Sylvia; Do, Nhu-Nguyen; Oliveira-Coelho, Ana; Fernandez Lahore, Gonzalo; Li, Taotao; Sabatier, Pierre; Beusch, Christian M; Viljanen, Johan; Zubarev, Roman A; Kihlberg, Jan; Bäcklund, Johan; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
      A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we ...

    • Vacuum extraction and pelvic floor injury : a randomized controlled trial and cohort studies 

      Bergendahl, Sandra (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-02-06)
      BACKGROUND AND AIMS: Pelvic floor dysfunction (PFD) affects many women, especially after complicated childbirth. The impact of a prolonged second stage on PFD is not clear, while the effects of operative vaginal birth (OVB) ...