Publications from KI: Recent submissions
Now showing items 101-120 of 10115
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Novel diagnostic and prognostic tools in infiltrative cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-16)Background: Heart failure is a severe medical condition, increasingly common in the aging population, causing both vast morbidity and mortality. Amongst different etiologies of heart failure, infiltrative cardiomyopathies ... -
Understanding the roles of avidity in biological systems
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-04-11)Understanding avidity is essential for elucidating complex molecular interactions and designing effective therapeutic strategies. This thesis aims to explore strategies and tools to understand how avidity influences ... -
Cancer risk, autoimmune comorbidity and autoantibodies in primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-05)Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease affecting the bile ducts primarily, and the liver parenchyma secondarily. The disease is progressive but highly variable between diseased. Some ... -
Sexual and reproductive health and rights among newly arrived migrants in Sweden : knowledge gaps and healthcare challenges
(Inst för global folkhälsa / Dept of Global Public Health, 2024-04-04)Introduction: Migration is one of today’s most pressing issues, especially concerning sexual and reproductive health and rights (SRHR) and human rights. Migrants may face heightened health vulnerabilities due to challenges ... -
Lineage, cell state and cell identity in the developing human brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-04)Organisms are complex systems consisting of thousands of distinct types of cells that perform a wide array of functions, yet for the most part share the same DNA. To regulate the expression of genes, the genome contains a ... -
Oral graft versus host disease : salivary gland pathology and tissue modelling
(Inst för odontologi / Dept of Dental Medicine, 2024-04-04)Chronic Graft versus Host Disease (cGVHD) is a consequence of dysregulated immune reconstitution after allogenic hematopoietic cell transplantation (alloHCT), a treatment for high-risk blood malignancies or immune ... -
From vaccination to infection : mechanistic studies of immune responses to SARS-CoV-2
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-04)The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 elevated population-level immunity and reduced ... -
In search of therapeutic candidates for tandem repeat disorders
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-04)Triplet-repeat disorders, including Friedreich's Ataxia (FRDA) and Huntington's disease (HD), are genetic conditions characterized by the expansion of specific trinucleotide sequences within affected genes. In FRDA, the ... -
Physiological and lifestyle-related cardiovascular risk factors for vessels, ventricle, and valve
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-03)Cardiovascular diseases are the most common cause of mortality globally, claiming twice as many lives as cancer and more than all nutritional disorders, infectious diseases, and maternal/neonatal conditions combined. The ... -
Genetic studies of rare skeletal disorders : to solve the unsolved
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-03)Congenital skeletal disorders, also called skeletal dysplasias, constitute a diverse group of rare genetic conditions that occur in approximately 1 per 3000-5000 births. Skeletal dysplasias exhibit both clinical and molecular ... -
The role of inflammatory cells in sarcoidosis and asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-02)Immuno-homeostasis refers to maintaining a delicate balance between immune responses and tolerance. It relies on the harmonious interplay of various inflammatory cells, including macrophages, monocytes, dendritic cells, T ... -
Supportive resources for self-care and informal care : uncovering the role of patient-driven innovations
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-04-02)Background: Persons living with long-term conditions and informal caregivers are often dependent on support for their self-care and informal care. The experience of insufficient support may lead some to develop health ... -
Life changing moments : transitions and critical points in young-onset dementia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-04-02)Background: Persons who are diagnosed with dementia before the age of 65 are commonly referred to as persons with young-onset dementia (YOD). Younger persons and their families have different needs from those in older ... -
Using the force : targeting p60AmotL2-mediated invasion in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-28)Mechanotransduction is the process by which cells convert mechanical forces into biochemical signals—and vice versa—thanks to a coordinated cascade of effects regulated by mechanomodulatory and cytoskeletal complexes. These ... -
Improvement of microbiological diagnostics in sepsis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-03-27)Sepsis, a life-threatening condition characterized by a dysregulated host response to infection, poses significant diagnostic and therapeutic challenges, contributing to high morbidity and mortality rates worldwide. The ... -
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-27)Renal cell carcinoma (RCC) represents a significant clinical challenge due to its resistance to conventional therapies and its complex tumor microenvironment (TME). RCC's immunogenic nature, characterized by the infiltration ... -
Heart failure with preserved and reduced ejection fraction : comorbidities, therapies and cause-specific outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-27)Background: Heart failure (HF) is associated with worse prognosis and poor quality of life, and its rising global prevalence puts a growing strain on healthcare systems. While most previous studies have focused on ... -
Pharmacovigilance of mass drug administration as preventive chemotherapy to control and eliminate lymphatic filariasis in Tanzania
(Inst för global folkhälsa / Dept of Global Public Health, 2024-03-27)Mass drug administration (MDA) campaigns are usually conducted on an annual basis by many countries globally where neglected tropical diseases (NTDs), including lymphatic filariasis (LF), are endemic. Such campaigns are ... -
Noninvasive estimation of intracranial pressure with optic nerve sheath diameter sonography
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-26)Background: Modern neurointensive care aims to prevent or mitigate secondary cerebral insults after severe primary cerebral insults, such as subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI). Optimization of ... -
From preschool wheeze to childhood asthma : the role of genetics and environmental factors
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-26)Background: Respiratory illness with wheeze is very common at preschool age and is often the first clinical manifestation of asthma. Two-thirds of preschool wheezers outgrow their symptoms by their sixth birthday whereas ...