Publications from KI: Recent submissions
Now showing items 61-80 of 10020
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Am I mad, bad or dangerous? A novel intervention approach for unwanted intrusive thoughts
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-14)Background: Unwanted intrusive thoughts (UITs) containing unacceptable and taboo themes is regarded as a common and, for most, transient cognitive phenomenon. However, these thoughts can become so frequent and distressing ... -
Consumer reported digital immunization records : feasibility, applicability, and public health utility in the Canadian context
(Inst för global folkhälsa / Dept of Global Public Health, 2024-02-13)Background: Vaccination is one of the most effective public health interventions of all time. Public health programs collect data on Vaccination Coverage (VC) to determine levels of protection and guide resource allocation ... -
Parkinson's disease and Gaucher disease : focus on the GBA1 link
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-13)Parkinson’s disease (PD) is the 2nd most common neurodegenerative disorder in the world, characterized by both motor as well as many non-motor features. There are many symptomatic treatments available, that may shift ... -
Enhancing the efficiency of viral and non-viral gene delivery vectors
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-02-13)Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. ... -
Does online parent training measure up to group parent training in real-world settings?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-12)Background: Disruptive behavior problems involve recurrent patterns of defiance, aggression, and hostility that interfere with normal functioning. Disruptive behaviors are commonly observed in children and adolescents and ... -
Targeting the ovary : mapping mechanisms to link endocrine-disrupting chemicals to female fertility
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-09)In recent decades, growing attention has been paid to endocrine-disrupting chemicals (EDCs) as mounting evidence suggests that they can cause detrimental reproductive outcomes in animals and humans. Even though epidemiological ... -
The efficacy of continuous peripheral blocks after cardiothoracic surgery as evaluated by opioid use, pain, and recovery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-09)Pain after cardiothoracic surgery is most intense the first postoperative days and for the most part mild to moderate. International guidelines recommend a multimodal analgesic strategy that includes local anesthetics for ... -
Standardization of antigen-emulsion preparations for the induction of autoimmune disease models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-09)Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models, and the ... -
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, ... -
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we ... -
Vacuum extraction and pelvic floor injury : a randomized controlled trial and cohort studies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-02-06)BACKGROUND AND AIMS: Pelvic floor dysfunction (PFD) affects many women, especially after complicated childbirth. The impact of a prolonged second stage on PFD is not clear, while the effects of operative vaginal birth (OVB) ... -
Organic electronics and microphysiological systems to interface, monitor, and model biology
(Inst för neurovetenskap / Dept of Neuroscience, 2024-02-06)Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand ... -
Clinical characteristics and treatment outcomes in body dysmorphic disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-01)Body dysmorphic disorder (BDD) is an early onset mental disorder characterized by a preoccupation with perceived flaws in physical appearance. Research on the presentation of the disorder is sparse, especially on young ... -
Being prevented from providing good care : a conceptual analysis of moral stress among health care workers during the COVID-19 pandemic
(Inst för global folkhälsa / Dept of Global Public Health, 2024-01-31)Background Health care workers (HCWs) are susceptible to moral stress and distress when they are faced with morally challenging situations where it is difficult to act in line with their moral standards. In times of crisis, ... -
Cardiovascular magnetic resonance evaluation of effusive and constrictive physiologies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-31)This thesis presents an exploration of cardiovascular magnetic resonance (CMR) in the evaluation of effusive and constrictive heart conditions. Central to the thesis is advanced CMR as a diagnostic tool in pericardial ... -
Alcohol consumption and cognition
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-01-31)There is evidence that alcohol consumption is increasing in recent decades, including both male and female older individuals. Excessive alcohol use can affect various functions, of which alcohol-related liver failure and ... -
Reduced variability of bursting activity during working memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized ... -
Working memory control dynamics follow principles of spatial computing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts of beta and gamma oscillations. However, it is not clear how ... -
Understanding juvenile idiopathic arthritis : a multidimensional approach
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The overarching objective of this doctoral thesis is to enhance the understanding of Juvenile Idiopathic Arthritis (JIA), a complex autoimmune disease affecting children. With the aim of filling the knowledge gaps in JIA, ... -
Monitoring of the oral anticoagulants apixaban and rivaroxaban to optimize individual safety and efficacy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The oral anticoagulants apixaban and rivaroxaban are administered at fixed doses without requiring routine monitoring. However, there is a dose and exposure dependency in efficacy and safety, and monitoring the anticoagulants ...