The effect of a text-messaging intervention on retention in care for women living with HIV and their infants in Kenya
Author: Nordberg, Björn
Date: 2022-06-03
Location: David, Widerströmska huset, Karolinska Institutet, Solna
Time: 09.00
Department: Inst för global folkhälsa / Dept of Global Public Health
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Thesis (2.633Mb)
Abstract
Background: Retention in prevention of mother-to-child transmission (PMTCT) of HIV care is crucial to reduce vertical HIV transmission, and to improve the health and survival of women living with HIV and their infants. HIV-related stigma, social concerns, and non-disclosure of HIV status are barriers to participate in PMTCT care, which potentially could be addressed by supporting women with an interactive text-messaging intervention. The aim of this thesis was to increase knowledge of the effect of an interactive text-messaging intervention on retention in PMTCT care, and to shed light on pregnant women’s HIV status disclosure and their social and emotional barriers to participate in PMTCT care in Kenya.
Methods: We recruited pregnant women living with HIV to a randomised controlled trial at six antenatal care clinics in western Kenya between June 2015 to July 2016. The participants in the intervention group received weekly text messages until 24 months postpartum, to which they were requested to respond within 48 hours if they were okay or if they had a problem. Interview data collected at study enrolment at four of the clinics were used to investigate participants’ social concerns to participate in PMTCT care and their association to HIV status disclosure (paper I). We compared the uptake of early infant HIV testing (paper II), and 18-month retention in PMTCT care (paper III) between the intervention and control group at all six clinics. We also investigated women’s adherence to respond if they were okay or had a problem in a cohort study of the intervention group participants (paper IV).
Results: In paper I, we observed that 80% of the women who were married or living with a partner had disclosed their HIV status to their partner. Women 35-44 years old had lower odds of HIV status disclosure to a partner (odds ratio [OR]: 0.15; 95% confidence interval [CI]: 0.05-0.44) compared to women 18-24 years old. Women reporting concerns about isolation or lack of support from family or friends (OR: 0.33; 95% CI: 0.12-0.85), separation from a partner (OR: 0.17; 95% CI: 0.05-0.57), or conflict with a partner (OR: 0.18; 95% CI: 0.05-0.67) had lower odds of HIV disclosure to a partner. In paper II we observed no effect of interactive text messaging on uptake of early infant HIV testing in the intervention group compared to the control group (rate ratio [RR]: 0.99; 95% CI: 0.90-1.10; p=0.89). In paper III, 18-month retention in care was similar in the intervention (70%) and the control group (69%) (RR: 1.02; 95% CI: 0.92-1.14; p=0.70). In paper IV we observed that women in the intervention group responded to 49% of the text messages sent to them (48% were okay responses and 1% were problem responses). Women 18-24 years old (OR: 2.20; 95% CI: 1.03-4.72) were more likely to respond to <50% of the text messages compared to women 35-44 years old. Women with higher education (OR: 0.28; 95% CI: 0.13-0.64) were less likely to respond to <50% of the text messages compared to women with lower education. Among the 59% of women who were interviewed at the end of the intervention, 95% reported that the intervention had been helpful, mainly by improving access to and communication with healthcare providers.
Conclusion: Younger women were more likely to disclose their HIV status to a partner, possibly indicating lower HIV-related stigma in younger generations in Kenya. However, our results suggest that concerns about isolation, lack of support, separation, and conflict with a partner still prevail and may be barriers that should be addressed to further increase women’s HIV status disclosure to partners. Our results suggest that interactive text messaging does not improve the uptake of early infant HIV testing or 18-month retention in PMTCT care. The modest use of the intervention to report a problem and sending weekly responses, particularly among women of lower education and younger age, should be considered in the design of future interventions aiming to improve outcomes of PMTCT care. Interactive text messaging may be useful to improve access to and communication with healthcare providers for women in PMTCT care.
Methods: We recruited pregnant women living with HIV to a randomised controlled trial at six antenatal care clinics in western Kenya between June 2015 to July 2016. The participants in the intervention group received weekly text messages until 24 months postpartum, to which they were requested to respond within 48 hours if they were okay or if they had a problem. Interview data collected at study enrolment at four of the clinics were used to investigate participants’ social concerns to participate in PMTCT care and their association to HIV status disclosure (paper I). We compared the uptake of early infant HIV testing (paper II), and 18-month retention in PMTCT care (paper III) between the intervention and control group at all six clinics. We also investigated women’s adherence to respond if they were okay or had a problem in a cohort study of the intervention group participants (paper IV).
Results: In paper I, we observed that 80% of the women who were married or living with a partner had disclosed their HIV status to their partner. Women 35-44 years old had lower odds of HIV status disclosure to a partner (odds ratio [OR]: 0.15; 95% confidence interval [CI]: 0.05-0.44) compared to women 18-24 years old. Women reporting concerns about isolation or lack of support from family or friends (OR: 0.33; 95% CI: 0.12-0.85), separation from a partner (OR: 0.17; 95% CI: 0.05-0.57), or conflict with a partner (OR: 0.18; 95% CI: 0.05-0.67) had lower odds of HIV disclosure to a partner. In paper II we observed no effect of interactive text messaging on uptake of early infant HIV testing in the intervention group compared to the control group (rate ratio [RR]: 0.99; 95% CI: 0.90-1.10; p=0.89). In paper III, 18-month retention in care was similar in the intervention (70%) and the control group (69%) (RR: 1.02; 95% CI: 0.92-1.14; p=0.70). In paper IV we observed that women in the intervention group responded to 49% of the text messages sent to them (48% were okay responses and 1% were problem responses). Women 18-24 years old (OR: 2.20; 95% CI: 1.03-4.72) were more likely to respond to <50% of the text messages compared to women 35-44 years old. Women with higher education (OR: 0.28; 95% CI: 0.13-0.64) were less likely to respond to <50% of the text messages compared to women with lower education. Among the 59% of women who were interviewed at the end of the intervention, 95% reported that the intervention had been helpful, mainly by improving access to and communication with healthcare providers.
Conclusion: Younger women were more likely to disclose their HIV status to a partner, possibly indicating lower HIV-related stigma in younger generations in Kenya. However, our results suggest that concerns about isolation, lack of support, separation, and conflict with a partner still prevail and may be barriers that should be addressed to further increase women’s HIV status disclosure to partners. Our results suggest that interactive text messaging does not improve the uptake of early infant HIV testing or 18-month retention in PMTCT care. The modest use of the intervention to report a problem and sending weekly responses, particularly among women of lower education and younger age, should be considered in the design of future interventions aiming to improve outcomes of PMTCT care. Interactive text messaging may be useful to improve access to and communication with healthcare providers for women in PMTCT care.
List of papers:
I. Björn Nordberg, Erin E Gabriel, Edwin Were, Eunice Kaguiri, Anna Mia Ekström, Anna E Kågesten, Susanne Rautiainen. Social concerns related to HIV status disclosure and participation in the prevention of mother-to-child transmission of HIV care among pregnant women in Kenya. BMC Pregnancy and Childbirth. 2020, 20:225.
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II. Björn Nordberg, Winfred Mwangi, Mia Liisa van der Kop, Edwin Were, Eunice Kaguiri, Anna E Kågesten, Erin E Gabriel, Richard T Lester, Jonathan Mwangi, Anna Mia Ekström, Susanne Rautiainen. The effect of weekly interactive text-messaging on early infant HIV testing in Kenya: a randomised controlled trial (WelTel PMTCT). Scientific Reports. 2021, 11:22652.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. Björn Nordberg, Mia Liisa van der Kop, Jonathan Mwangi, Eunice Kaguiri, Katrine J Chamorro de Angeles, Richard T Lester, Erin E Gabriel, Susanne Rautiainen, Patricia Awiti, Anna E Kågesten, Edwin Were, Anna Mia Ekström. The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT). [Submitted]
IV. Björn Nordberg, Eunice Kaguiri, Erin E Gabriel, Mia Liisa van der Kop, Katrine J Chamorro de Angeles, Winfred Mwangi, Richard T Lester, Edwin Were, Anna Mia Ekström, Susanne Rautiainen. The use, adherence, and evaluation of interactive text messaging among women admitted to prevention of mother-to-child transmission of HIV care in Kenya (WelTel PMTCT). [Manuscript]
I. Björn Nordberg, Erin E Gabriel, Edwin Were, Eunice Kaguiri, Anna Mia Ekström, Anna E Kågesten, Susanne Rautiainen. Social concerns related to HIV status disclosure and participation in the prevention of mother-to-child transmission of HIV care among pregnant women in Kenya. BMC Pregnancy and Childbirth. 2020, 20:225.
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. Björn Nordberg, Winfred Mwangi, Mia Liisa van der Kop, Edwin Were, Eunice Kaguiri, Anna E Kågesten, Erin E Gabriel, Richard T Lester, Jonathan Mwangi, Anna Mia Ekström, Susanne Rautiainen. The effect of weekly interactive text-messaging on early infant HIV testing in Kenya: a randomised controlled trial (WelTel PMTCT). Scientific Reports. 2021, 11:22652.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. Björn Nordberg, Mia Liisa van der Kop, Jonathan Mwangi, Eunice Kaguiri, Katrine J Chamorro de Angeles, Richard T Lester, Erin E Gabriel, Susanne Rautiainen, Patricia Awiti, Anna E Kågesten, Edwin Were, Anna Mia Ekström. The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT). [Submitted]
IV. Björn Nordberg, Eunice Kaguiri, Erin E Gabriel, Mia Liisa van der Kop, Katrine J Chamorro de Angeles, Winfred Mwangi, Richard T Lester, Edwin Were, Anna Mia Ekström, Susanne Rautiainen. The use, adherence, and evaluation of interactive text messaging among women admitted to prevention of mother-to-child transmission of HIV care in Kenya (WelTel PMTCT). [Manuscript]
Institution: Karolinska Institutet
Supervisor: Rautiainen Lagerström, Susanne
Co-supervisor: Ekström, Anna Mia; Gabriel, Erin E.; Were, Edwin
Issue date: 2022-05-12
Rights:
Publication year: 2022
ISBN: 978-91-8016-571-6
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