Artiklar / Articles - SwePub: Recent submissions

Now showing items 41-60 of 404

    • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy 

      Beverborg, Niels Grote; Spater, Daniela; Knoll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Sillje, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmer, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)
      Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...

    • An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation 

      Rohner, Eduarde; Witman, Nevin; Sohlmér, Jesper; De Genst, Erwin; Louch, William E; Sahara, Makoto; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)
      Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ...

    • Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors 

      Poch, Christine M; Foo, Kylie S; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Bähr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymiuk, Nikolai; Lu, Kun; Tomasi, Roland; Dendorfer, Andreas; Gaspari, Marco; Parrotta, Elvira; Cuda, Giovanni; Krane, Markus; Sinnecker, Daniel; Hoppmann, Petra; Kupatt, Christian; Fritsche-Danielson, Regina; Moretti, Alessandra; Chien, Kenneth R; Laugwitz, Karl-Ludwig (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-02)
      Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft ...

    • Cadmium intake as a prognostic factor in endometrial cancer : a Swedish cohort-based study 

      Razumova, Zoia; Govorov, Igor; Östensson, Ellinor; Mints, Miriam (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2022-04-22)
      Metalloendocrinology is a new interdisciplinary field, which was established due to the importance of connections between inorganic chemicals and hormonal mechanisms. The role of cadmium in hormone-related tumors is an ...

    • The prognostic role of LRIG proteins in endometrial cancer 

      Razumova, Zoia; Oda, Husam; Govorov, Igor; Lundin, Eva; Östensson, Ellinor; Lindquist, David; Mints, Miriam (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2022-04-22)
      Endometrial cancer (EC) is the most common gynecologic malignancy in Sweden and it has various prognostic factors. The LRIG family is a group of three integral surface proteins with a similar domain organization. The ...

    • Contrast-enhanced ultrasound is useful for the evaluation of focal liver lesions in children 

      Torres, Alvaro; Koskinen, Seppo K; Gjertsen, Henrik; Fischler, Björn (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2022-03-28)
      Introduction: Contrast-enhanced ultrasound (CEUS) is a widely used diagnostic method. In adults, it has been proven to be a useful alternative to CT and MRI for the characterisation of focal liver lesions (FLLs). However, ...

    • Contrast-enhanced ultrasound for identifying circulatory complications after liver transplants in children 

      Torres, Alvaro; Koskinen, Seppo K; Gjertsen, Henrik; Fischler, Björn (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2022-03-28)
      Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations performed on 34 pediatric ...

    • Contrast-enhanced ultrasound using sulfur hexafluoride is safe in the pediatric setting 

      Torres, Alvaro; Koskinen, Seppo K; Gjertsen, Henrik; Fischler, Björn (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2022-03-28)
      Background: Contrast-enhanced ultrasound (CEUS) by using sulfur hexafluoride microbubbles is not licensed for use in children, but its off-label use is widespread. Purpose: To outline our experience with the off-label ...

    • Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation 

      Berglund, Rasmus; Guerreiro Cacais, Andre Ortlieb; Adzemovic, Milena Z; Zeitelhofer, Manuel; Lund, Harald; Ewing, Ewoud; Ruhrmann, Sabrina; Nutma, Erik; Parsa, Roham; Thessén Hedreul, Mélanie; Amor, Sandra; Harris, Robert A; Olsson, Tomas; Jagodic, Maja (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-12-14)
      Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ...

    • MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells 

      Karsten, Stella; Fiskesund, Roland; Zhang, Xing-Mei; Marttila, Petra; Sanjiv, Kumar; Pham, Therese; Rasti, Azita; Bräutigam, Lars; Almlöf, Ingrid; Marcusson-Ståhl, Maritha; Sandman, Carolina; Platzack, Björn; Harris, Robert A; Kalderén, Christina; Cederbrant, Karin; Helleday, Thomas; Warpman Berglund, Ulrika (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)
      T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ...

    • Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction 

      Foo, Kylie S; Lehtinen, Miia L; Lian, Xiaojun; Xu, Jiejia; Keung, Wendy; Geng, Lin; Kolstad, Terje R S; Thams, Sebastian; Wong, Andy On-tik; Wong, Nicodemus; Bylund, Kristine; Zhou, Chikai; He, Xiaobing; Jin, Shao-Bo; Clarke, Jonathan; Lendahl, Urban; Li, Ronald A; Louch, William E; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-01)
      The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...

    • Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden 

      Mogensen, Hanna; Modig, Karin; Talbäck, Mats; Erdmann, Friederike; Heyman, Mats; Feychting, Maria; Tettamanti, Giorgio (Institutet för miljömedicin / Institute of Environmental Medicine, 2021-05-31)
      Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ...

    • Detecting prolonged sitting bouts with the ActiGraph GT3X 

      Kuster, Roman P; Grooten, Wilhelmus J A; Baumgartner, Daniel; Blom, Victoria; Hagströmer, Maria; Ekblom, Örjan (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
      The ActiGraph has a high ability to measure physical activity; however, it lacks an accurate posture classification to measure sedentary behavior. The aim of the present study was to develop an ActiGraph (waist-worn, 30 ...

    • Network asynchrony underlying increased broadband gamma power 

      Guyon, Nicolas; Zacharias, Leonardo Rakauskas; de Oliveira, Eliezyer Fermino; Kim, Hoseok; Leite, João Pereira; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
      Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV) underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is associated with increased broadband γ power in the ...

    • Active sitting with backrest support : is it feasible? 

      Kuster, Roman P; Bauer, Christoph M; Gossweiler, Lukas; Baumgartner, Daniel (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
      Ergonomics science recommends office chairs that promote active sitting to reduce sitting related complaints. Since current office chairs do not fulfil this recommendation, a new chair was developed by inverting an existing ...

    • Where to place which sensor to measure sedentary behaviour? A method development and comparison among various sensor placements and signal types 

      Kuster, Roman P; Baumgartner, Daniel; Hagströmer, Maria; Grooten, Wilhelmus J A (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
      Background: Sedentary Behaviour (SB) is associated with several chronic diseases and especially office workers are at increased risk. SB is defined by a sitting or reclined body posture with an energy expenditure ≤1.5 METs. ...

    • Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics 

      Guyon, Nicolas; Zacharias, Leonardo Rakauskas; van Lunteren, Josina Anna; Immenschuh, Jana; Fuzik, Janos; Märtin, Antje; Xuan, Yang; Zilberter, Misha; Kim, Hoseok; Meletis, Konstantinos; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
      Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of c oscillations, and cognition. Dysfunction of PV interneurons disrupts cortical information processing and cognitive ...

    • Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5 

      Golembiewska, Edyta; Qureshi, Abdul Rashid; Dai, Lu; Lindholm, Bengt; Heimbürger, Olof; Söderberg, Magnus; Brismar, Torkel B; Ripsweden, Jonaz; Barany, Peter; Johnson, Richard J; Stenvinkel, Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
      Background: Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30– 70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine ...

    • Early vascular ageing and cellular senescence in chronic kidney disease 

      Dai, Lu; Qureshi, Abdul Rashid; Witasp, Anna; Lindholm, Bengt; Stenvinkel, Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
      Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular dis- ease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process ...

    • A DNA-nanoassembly-based approach to map membrane protein nanoenvironments 

      Ambrosetti, Elena; Bernardinelli, Giulio; Hoffecker, Ian; Hartmanis, Leonard; Kiriako, Georges; de Marco, Ario; Sandberg, Rickard; Högberg, Björn; Teixeira, Ana I (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)
      Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ...