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  • X-chromosome upregulation is driven by increased burst frequency 

    Larsson , Anton J. M.; Coucoravas, Christos; Sandberg, Rickard; Reinius, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)
    Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
  • Risk factors and tumor characteristics of interval cancers by mammographic density 

    Holm, Johanna; Humphreys, Keith; Li, Jingmei; Ploner, Alexander; Cheddad, Abbas; Eriksson, Mikael; Törnberg, Sven; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-23)
    Purpose: To compare tumor characteristics and risk factors of interval breast cancers and screen-detected breast cancers, taking mammographic density into account. Patients and Methods: Women diagnosed with invasive ...
  • Associations of breast cancer risk prediction tools with tumor characteristics and metastasis 

    Holm, Johanna; Li, Jingmei; Darabi, Hatef; Eklund, Martin; Eriksson, Mikael; Humphreys, Keith; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-23)
    Purpose: The association between established risk factors for breast cancer and subtypes or prognosis of the disease is not well known. We analyzed whether the Tyrer-Cuzick–predicted 10-year breast cancer risk score (TCRS), ...
  • Breast cancer genetic risk profile is differentially associated with interval and screen-detected breast cancers 

    Li, Jingmei; Holm, Johanna; Bergh, Jonas C.S.; Eriksson, Mikael; Darabi, Hatef; Lindström, Linda Sofie; Törnberg, Sven A.; Hall, Per F.L.; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Background: Polygenic risk profiles computed from multiple common susceptibility alleles for breast cancer have been shown to identify women at different levels of breast cancer risk. We evaluated whether this genetic ...
  • Assessment of breast cancer risk factors reveals subtype heterogeneity 

    Holm, J; Eriksson, L; Ploner, A; Eriksson, M; Rantalainen, M; Li, J; Hall, P; Czene, K (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. Reports are conflicting regarding presence of heterogeneity for many ...
  • Time-dependent risk of depression, anxiety, and stress-related disorders in patients with invasive and in situ breast cancer 

    Yang, Haomin; Brand, Judith S.; Fang, Fang; Chiesa, Flaminia; Johansson, Anna L.V.; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Despite concerns about the mental health of breast cancer patients, little is known regarding the temporal risk pattern and risk factors of common mental disorders among these patients. We estimated standardized incidence ...
  • Time from breast cancer diagnosis to therapeutic surgery and breast cancer prognosis : a population-based cohort study 

    Eriksson, Louise; Bergh, Jonas; Humphreys, Keith; Wärnberg, Fredrik; Törnberg, Sven; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Theoretically, time from breast cancer diagnosis to therapeutic surgery should affect survival. However, it is unclear whether this holds true in a modern healthcare setting in which breast cancer surgery is carried out ...
  • Prediction of individuals at high absolute risk of esophageal squamous cell carcinoma 

    Wang, Qiaoli; Lagergren, Jesper; Xie, Shao-Hua (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgerySchool of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom, 2020-03-18)
    Background and Aims: This study aimed to develop a prediction model for identifying individuals at high absolute risk of esophageal squamous cell carcinoma (ESCC) for endoscopic screening at a curable stage based on readily ...
  • Global time trends in the incidence of esophageal squamous cell carcinoma 

    Wang, Qiao-Li; Xie, Shao-Hua; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)
    Background & Aims: Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer worldwide (90%). We aimed to provide an update of the global temporal trends in the incidence of ...
  • Association between levels of sex hormones and risk of esophageal adenocarcinoma and Barrett’s esophagus 

    Xie, Shaohua; Fang, Rui; Huang, Mingtao; Dai, Juncheng; Thrift, Aaron P.; Anderson, Lesley A.; Chow, Wong-Ho; Bernstein, Leslie; Gammon, Marilie D.; Risch, Harvey A.; Shaheen, Nicholas J.; Reid, Brian J.; Wu, Anna H.; Iyer, Prasad G.; Liu, Geoffrey; Corley, Douglas A.; Whiteman, David C.; Caldas, Carlos; Pharoah, Paul D.; Hardie, Laura J.; Fitzgerald, Rebecca C.; Shen, Hongbing; Vaughan, Thomas L.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-18)
    Background & Aims: Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that regulate levels of sex hormones associated ...
  • Association between metformin use and risk of esophageal squamous cell carcinoma in a population-based cohort study 

    Wang, Qiao-Li; Santoni, Giola; Ness-Jensen, Eivind; Lagergren, Jesper; Xie, Shao-Hua (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, NorwayMedical Department, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, NorwaySchool of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom, 2020-03-11)
    Objectives: Esophageal cancer is a highly fatal malignant neoplasm, with two etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal ...
  • Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma 

    Kere, Maura; Gruzieva, Olena; Ullemar, Vilhelmina; Söderhäll, Cilla; Greco, Dario; Kull, Inger; Bergström, Anna; Pershagen, Göran; Almqvist, Catarina; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-09-25)
  • Cardiac remodeling in aortic and mitral valve disease : a simulation study with clinical validation 

    Maksuti, Elira; Westerhof, Berend; Ugander, Martin; Donker, Dirk; Carlsson, Marcus; Broomé, Michael (Inst för fysiologi och farmakologi / Dept of Physiology and PharmacologyKarolinska Universitetssjukhuset Solna / Karolinska University Hospital Solna, 2019-09-03)
    Background. Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we ...
  • Sibship and dispensing patterns of asthma medication in young children : a population based study 

    Dahlén, Elin; Lundholm, Cecilia; Wikström Jonsson, Eva; Kull, Inger; Wettermark, Björn; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Purpose: Our aim was to study the association between sibship and dispensing patterns of asthma medication in young children, focusing on incidence and persistence, and taking sibship status, asthma diagnoses, and siblings’ ...
  • Cesarean delivery, preterm birth and risk of food allergy : nationwide Swedish cohort study of over 1 million children 

    Mitselou, Niki; Hallberg, Jenny; Stephansson, Olof; Almqvist, Catarina; Melén, Erik; Ludvigsson, Jonas F (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Background & Objectives: Little is known about early life risk factors for food allergy in children. We examined the association between perinatal characteristics and future risk of food allergy in offspring. Methods: ...
  • Everyday technologies and public space participation among people with and without dementia 

    Gaber, Sophie Nadia; Nygard, L; Brorsson, A; Kottorp, A; Malinowsky, C (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and SocietyMalmö University, 2019-06-12)
    BACKGROUND: Occupational therapists support everyday technology use; however, it is necessary to consider the challenges that people with dementia encounter with everyday technologies when participating in various places ...
  • Effects of design choices on the stiffness of wireframe DNA origami structures 

    Benson, Erik; Mohammed, Abdulmelik; Rayneau-Kirkhope, Daniel; Gådin, Andreas; Orponen, Pekka; Högberg, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24)
  • Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample 

    Rydell, Mina; Lundström, Sebastian; Gillberg, Christopher; Lichtenstein, Paul; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-03-27)
    Background: Studies have reported increases in clinically diagnosed and treated Attention deficit hyperactivity disorder (ADHD) during the last decade, but it is unclear if this reflects an increase in the underlying ADHD ...
  • Efficacy and cost-effectiveness of therapist-guided internet cognitive behavioural therapy for paediatric anxiety disorders : a single-centre, single-blind, randomised controlled trial 

    Jolstedt, Maral; Wahlund, Tove; Lenhard, Fabian; Ljótsson, Brjánn; Mataix-Cols, David; Nord, Martina; Öst, Lars-Göran; Högström, Jens; Serlachius, Eva; Vigerland, Sarah (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-27)
    Background: Paediatric anxiety disorders are prevalent and associated with substantial disability and long-term adverse consequences. Only a minority of affected children have access to evidence-based treatment; ...
  • How chronic is polypharmacy in old age? A longitudinal nationwide cohort study 

    Wastesson, Jonas W; Morin, Lucas; Laroche, Marie-Laure; Johnell, Kristina (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-03-14)
    OBJECTIVE: To evaluate the chronicity of polypharmacy among older adults, and to identify factors associated with chronic polypharmacy. DESIGN: Longitudinal cohort study using register data. SETTING: Nationwide, ...

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