Now showing items 121-140 of 404

    • Quality of life and psychological and gastrointestinal symptoms after cholecystectomy : a population-based cohort study 

      Talseth, Arne; Edna, Tom-Harald; Hveem, Kristian; Lydersen, Stian; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
      OBJECTIVE: The study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy. DESIGN: This is a prospective population-based cohort study based on the ...
    • Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder : a pilot study 

      Tangen, Ämma; Borg, Jacqueline; Tiger, Mikael; Varnäs, Katarina; Sorjonen, Kimmo; Lindefors, Nils; Halldin, Christer; Lundberg, Johan (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-01-04)
      The neurotransmitter serotonin has been widely implicated in the pathophysiology of major depressive disorder (MDD). In animal studies and human neuroimaging studies, involvement of the serotonin receptor 1B (5-HT1BR) in ...
    • Education in twins and their parents across birth cohorts over 100 years : an individual-level pooled analysis of 42 twin cohorts 

      Silventoinen, Karri; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Yokoyama, Yoshie; Ullemar, Vilhelmina; Almqvist, Catarina; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth J F; Kandler, Christian; Honda, Chika; Inui, Fujio; Iwatani, Yoshinori; Watanabe, Mikio; Rebato, Esther; Stazi, Maria A; Fagnani, Corrado; Brescianini, Sonia; Hur, Yoon-Mi; Jeong, Hoe-Uk; Cutler, Tessa L; Hopper, John L; Busjahn, Andreas; Saudino, Kimberly J; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rose, Richard J; Koskenvuo, Markku; Heikkilae, Kauko; Cozen, Wendy; Hwang, Amie E; Mack, Thomas M; Siribaddana, Sisira H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling V; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Nelson, Tracy L; Whitfield, Keith E; Tan, Qihua; Zhang, Dongfeng; Llewellyn, Clare H; Fisher, Abigail; Burt, S Alexandra; Klump, Kelly L; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Medland, Sarah E; Martin, Nicholas G; Montgomery, Grant W; Magnusson, Patrik K E; Pedersen, Nancy L; Aslan, Anna K Dahl; Corley, Robin P; Huibregtse, Brooke M; OEncel, Sevgi Y; Aliev, Fazil; Krueger, Robert F; Mcgue, Matt; Pahlen, Shandell; Willemsen, Gonneke; Bartels, Meike; Van Beijsterveldt, Catharina E M; Silberg, Judy L; Eaves, Lindon J; Maes, Hermine H; Harris, Jennifer R; Brandt, Ingunn; Nilsen, Thomas S; Rasmussen, Finn; Tynelius, Per; Baker, Laura A; Tuvblad, Catherine; Ordonana, Juan R; Sanchez-Romera, Juan F; Colodro-Conde, Lucia; Gatz, Margaret; Butler, David A; Lichtenstein, Paul; Goldberg, Jack H; Harden, K Paige; Tucker-Drob, Elliot M; Duncan, Glen E; Buchwald, Dedra; Tarnoki, Adam D; Tarnoki, David L; Franz, Carol E; Kremen, William S; Lyons, Michael J; Maia, Jose A; Freitas, Duarte L; Turkheimer, Eric; Sorensen, Thorkild I A; Boomsma, Dorret I; Kaprio, Jaakko (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-12-22)
      Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there ...
    • A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders 

      Mataix-Cols, David; Frans, Emma; Pérez-Vigil, Ana; Kuja-Halkola, Ralf; Gromark, Caroline; Isomura, Kayoko; Fernández de la Cruz, Lorena; Serlachius, Eva; Leckman, James F; Crowley, James J; Rück, Christian; Almqvist, Catarina; Lichtenstein, Paul; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-11-29)
      The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity ...
    • Why doesn’t everyone love reading e-books? 

      Myrberg, Caroline (Karolinska Institutet Universitetsbiblioteket / Karolinska Institutet University Library, 2017-11-15)
      Why do many students still prefer paper books to e-books? This article summarizes a number of problems with e-books mentioned in different studies by students of higher education, but it also discusses some of the unexploited ...
    • Smoking cessation and risk of esophageal cancer by histological type : systematic review and meta-analysis 

      Wang, Qiao-Li; Xie, Shao-Hua; Li, Wen-Tao; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-06)
      Smoking cessation is associated with a rapid and strong reduction in the risk of esophageal squamous cell carcinoma. The benefits of smoking cessation on esophageal squamous cell carcinoma are stronger in Western populations ...
    • eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences 

      Pelechano, Vicent; Alepuz, Paula (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-10-31)
      eIF5A is an essential protein involved in protein synthesis, cell proliferation and animal development. High eIF5A expression is observed in many tumor types and has been linked to cancer metastasis. Recent studies have ...
    • From transcriptional complexity to cellular phenotypes : lessons from yeast 

      Pelechano, Vicent (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-10-27)
      Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological ...
    • European bioimaging facility survey report 

      Lyytinen, Jaakko; Lundqvist, Daniel (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-10-05)
      This report describes the results of a survey undertaking by NatMEG (the Swedish national facility for magnetoencephalography; www.natmeg.se), performed under the auspices of Swedish Bioimaging. The three Swedish national ...
    • Health‑related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma 

      Ringborg, Cecilia; Johar, Asif; Lagergren, Jesper; Lagergren, Pernilla; Kauppila, Joonas H (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-04)
      BACKGROUND: The postoperative health-related quality of life (HRQOL) outcomes in patients with gastroesophageal junction (GEJ) adenocarcinoma after gastrectomy and esophagectomy are unclear. The aim was to evaluate HRQOL ...
    • Sensitivity of Salmonella YG5161 for detecting PAH-associated mutagenicity in air particulate matter 

      Umbuzeiro, Gisela A; Kummrow, Fabio; Morales, Daniel A; Alves, Debora Kristina M; Lim, Hwanmi; Jarvis, Ian W H; Bergvall, Christoffer; Westerholm, Roger; Stenius, Ulla; Dreij, Kristian (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      The Salmonella/microsome assay is the most used assay for the evaluation of air particulate matter (PM) mutagenicity and a positive correlation between strain TA98 responses and benzo[a]pyrene (B[a]P) levels in PM has been ...
    • Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment 

      Jarvis, Ian W H; Dreij, Kristian; Mattsson, Åse; Jernström, Bengt; Stenius, Ulla (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo on mechanisms related to carcinogenesis. Of particular concern regarding exposure to complex PAH mixtures is how interactions ...
    • Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells 

      Jarvis, Ian W H; Bergvall, Christoffer; Morales, Daniel A; Kummrow, Fabio; Umbuzeiro, Gisela A; Westerholm, Roger; Stenius, Ulla; Dreij, Kristian (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular ...
    • Benzo[a]pyrene-specific online high-performance liquid chromatography fractionation of air particulate extracts : a tool for evaluating biological interactions 

      Lim, Hwanmi; Bergvall, Christoffer; Jarvis, Ian W H; Mattsson, Åse; Dreij, Kristian; Stenius, Ulla; Westerholm, Roger (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      Benzo[a]pyrene (B[a]P) is a known human carcinogen and is commonly used as a surrogate for assessing the carcinogenic risk posed by complex mixtures of polycyclic aromatic hydrocarbons (PAHs) present in air particulate ...
    • Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity : a population based familial co-aggregation study in Sweden 

      Chen, Qi; Kuja-Halkola, Ralf; Sjölander, Arvid; Serlachius, Eva; Cortese, Samuele; Faraone, Stephen V; Almqvist, Catarina; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)
      BACKGROUND: Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. ...
    • Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter 

      Jarvis, Ian W H; Bergvall, Christoffer; Bottai, Matteo; Westerholm, Roger; Stenius, Ulla; Dreij, Kristian (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are present in air particulate matter (PM) and have been associated with many adverse human health effects including cancer and respiratory disease. However, due ...
    • Detection of benz[j]aceanthrylene in urban air and evaluation of its genotoxic potential 

      Lim, Hwanmi; Mattsson, Åse; Jarvis, Ian W H; Bergvall, Christoffer; Bottai, Matteo; Morales, Daniel A; Kummrow, Fabio; Umbuzeiro, Gisela A; Stenius, Ulla; Westerholm, Roger; Dreij, Kristian (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)
      Benz[j]aceanthrylene (B[j]A) is a cyclopenta-fused polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects. We have identified B[j]A in air particulate matter (PM) in samples collected in Stockholm, ...
    • Genetic and environmental contributions to the association between ADHD and affective problems in early childhood : a Swedish population-based twin study 

      Rydell, Mina; Taylor, Mark J; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)
      Few twin studies have explored the relative contribution of genetic and environmental factors to the association between attention deficit hyperactivity disorder (ADHD) and affective problems, and no study has focused on ...
    • Using fathers as a negative control exposure to test the developmental origins of health and disease hypothesis : a case study on maternal distress and offspring asthma using Swedish register data 

      Brew, Bronwyn K; Gong, Tong; Williams, Dylan M; Larsson, Henrik; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)
      Background: Developmental Origins of Health and Disease Hypothesis (DOHaD) studies are often observational in nature and are therefore prone to biases from loss to follow-up and unmeasured confounding. Register-based ...
    • A family-based study of the association between labor induction and offspring attention-deficit hyperactivity disorder and low academic achievement 

      Wiggs, Kelsey K; Rickert, Martin E; Hernandez-Diaz, Sonia; Bateman, Brian T; Almqvist, Catarina; Larsson, Henrik; Lichtenstein, Paul; Öberg, Anna Sara; D'Onofrio, Brian M (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)
      The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of ...