SwePub Export: Recent submissions
Now showing items 61-80 of 9950
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Renal Doppler resistive index : applications in perioperative and critical care
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)Doppler-derived renal resistive index (RRI) has emerged as a promising bedside tool for assessing renal hemodynamics, and elevated values ≥0.70 have been associated with adverse outcomes in various clinical settings. This ... -
Single-cell analysis on specification of mammalian germline and its role in health and diseases
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)Germ cell specification is the first step for developing reproductive cells. The specification requires formative pluripotent stem cells as precursors. Previous attempts to capture formative pluripotency used opposite ... -
Meeting the needs of women : provision of long-acting reversible contraception at the time of abortion
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-03-25)Background and aim: Unintended pregnancies represent a notable public health challenge, imposing substantial social and financial burdens on a global scale. In Sweden, approximately 37,000 abortions are conducted annually, ... -
Temporal response to bioenergetic stress in adipose tissue and skeletal muscle
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-22)Diabetes is a common disease—affecting more than 500 million people. Although type 2 diabetes maintains a genetic component—the implementation of lifestyle modification serves as a potent risk-reducing modality. Chronic ... -
Development and function of GABAergic neurons in health and in a predisposition model of schizophrenia
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-03-21)In this thesis, I present four studies which examine i) the role of transcript factor Sox6 in the development and maintenance of cortical Sst interneurons, ii) the involvement of cortical neurogliaform cells (NGFCs) in the ... -
Automated external defibrillator-equipped drones for facilitating early defibrillation in out-of-hospital cardiac arrest
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-20)Background: Each year, approximately 3.8 million out-of-hospital cardiac arrests (OHCAs) occur globally. Survival rates are low (8–12%) and have not increased during the past decade. It is known that early cardiopulmonary ... -
Pediatric eosinophilic esophagitis
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-19)Background and aims: Eosinophilic Esophagitis (EoE) is an immune-mediated antigentriggered inflammatory disease, strictly located to the esophagus. The pathogenesis is still partly unknown, and there is a lack of biomarkers ... -
Family planning service – addressing potential barriers
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)Background: Access to family planning service is crucial for reproductive health. Family planning service include contraceptive methods as well as safe methods for pregnancy termination when needed. It was estimated in ... -
Genetic and epigenetic risk factors for asthma in infancy and childhood
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)Asthma is among the most common non-communicable diseases, with an increasing prevalence worldwide. The pathophysiology behind the disease is heterogeneous, including risk factors like genes, sex, allergies, virus infections, ... -
Diabetes, cardiovascular events, and lifestyle : from epidemiology to clinic
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-15)Today, the health care system plays an important role in the prevention of diseases, not least through support of a healthy lifestyle, including being physically active. Given the development of digital tools together with ... -
Translational studies of glucocerebrosidase in Parkinson´s disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-14)A number of genetic variants have been linked to Parkinson’s disease (PD). Among these, mutations in the GBA1 gene are identified as one of the most common risk factors for developing PD. The connection between increased ... -
Benefit-harm assessment in childbirth care, with breech presentation as an illustration
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-11)Introduction: Childbirth care is aiming at safe births and positive birth experience. Obstetric decision-making is often complicated. Breech presentation is an example of such complexity. Judgements about individual cases ... -
Exploring statistical models for estimating remaining life years & loss in life expectancy for cancer patients
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-03-08)As advancements in cancer prognosis and treatment continue for many cancer types, there is a growing interest in estimating survival over longer time periods. The assessment of the years remaining after a cancer diagnosis, ... -
The role of thyroid hormone function and prokineticin-1 in pregnancy and offspring outcome in women with polycystic ovary syndrome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-06)Thyroid disorders are common in women with polycystic ovary syndrome (PCOS) and both conditions are associated with adverse pregnancy outcomes, such as intrauterine growth restriction, preterm delivery, and gestational ... -
Protein intake and healthy aging : sooner rather than later?
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-03-05) -
The role of pairing beyond the seed in microRNA targeting
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-03-01)MicroRNAs (miRNAs) are short non-coding RNAs which act as post-transcriptional regulators of gene expression. MiRNAs complex with Argonaute proteins to form an RNA-guided silencing complex (RISC). The guide RNA recognizes ... -
Exploring the gut microbiome in ADHD and schizophrenia spectrum disorder
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Emerging research indicates a complex relationship between the gut bacterial microbiome and psychiatric disorders, though findings are not always consistent. The gut-brain axis, involving gut microbiota, plays a crucial ... -
Cardiovascular magnetic resonance imaging of myocardium and pulmonary arterial pressure
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Heart failure (HF) is a clinical syndrome characterized by high morbidity and mortality. HF can be associated with alteration in myocardial tissue composition such as focal myocardial fibrosis, also referred to as scarring, ... -
Pathogenesis of IgA nephropathy and diabetic kidney disease : linking molecular profile to morphological and clinical picture
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-26)Background: More than 10% of the global population suffers from chronic kidney disease (CKD), which poses a large impact on society and, more importantly, the life of the affected patient. Two of the most common causes of ... -
Severe poisonings in Sweden : demography, intensive care, and death
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)Background: Poisonings are common and diverse in their origins, clinical presentations, and outcomes. Poisoning accounts for a substantial number of hospital admissions with need for a higher level of care. The hospital ...