SwePub Export: Recent submissions
Now showing items 41-60 of 9916
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Protein intake and healthy aging : sooner rather than later?
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-03-05) -
The role of pairing beyond the seed in microRNA targeting
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-03-01)MicroRNAs (miRNAs) are short non-coding RNAs which act as post-transcriptional regulators of gene expression. MiRNAs complex with Argonaute proteins to form an RNA-guided silencing complex (RISC). The guide RNA recognizes ... -
Exploring the gut microbiome in ADHD and schizophrenia spectrum disorder
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Emerging research indicates a complex relationship between the gut bacterial microbiome and psychiatric disorders, though findings are not always consistent. The gut-brain axis, involving gut microbiota, plays a crucial ... -
Cardiovascular magnetic resonance imaging of myocardium and pulmonary arterial pressure
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Heart failure (HF) is a clinical syndrome characterized by high morbidity and mortality. HF can be associated with alteration in myocardial tissue composition such as focal myocardial fibrosis, also referred to as scarring, ... -
Pathogenesis of IgA nephropathy and diabetic kidney disease : linking molecular profile to morphological and clinical picture
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-26)Background: More than 10% of the global population suffers from chronic kidney disease (CKD), which poses a large impact on society and, more importantly, the life of the affected patient. Two of the most common causes of ... -
Severe poisonings in Sweden : demography, intensive care, and death
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)Background: Poisonings are common and diverse in their origins, clinical presentations, and outcomes. Poisoning accounts for a substantial number of hospital admissions with need for a higher level of care. The hospital ... -
Radiation-induced toxicity and secondary malignant neoplasms in radiotherapy of intrathoracic tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-23)Radiation oncology is essential in the treatment of cancer, with approximately fifty percent of oncology patients undergoing radiotherapy (RT) at some stage of their disease management. Significant progress is being made ... -
Hemodynamic optimization in critically ill patients
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)Background: Intravenous fluids are one of the most common treatments in the health care setting and are usually given in response to hemodynamic instability or shock. However, this rests on the assumption that the cause ... -
Engineering cell communication from nanoscale to tissue levels towards therapeutic applications
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-02-22)Cell communication which is vital for the proper function, development, and survival of multicellular organisms is often disrupted in diseases. This thesis aims to enhance our understanding of cell communication by employing ... -
Novel ophthalmological assessments for detection of optic pathway gliomas in children
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-22)Optic pathway gliomas (OPGs) are vision-threatening brain lesions that are extremely important to detect at young age for appropriate medical intervention. Children with neurofibromatosis type 1 (NF1) are particularly at ... -
Imaging the spatial organization of healthy human brain and glioblastoma
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Multicellular biological systems have a single genetic plan that contains the set of instructions to shape the three-dimensional architecture of specialized tissues and organs. The genetic plan is contained in the DNA, and ... -
Regulation of mtDNA gene expression and the role of respiratory chain supercomplexes in mammalian mitochondria
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Mitochondria are cellular organelles found in nearly all eukaryotic cells, where they fulfill a plethora of functions, including energy conversion. They harness energy from carbon sources to synthesize adenosine triphosphate ... -
Mechanisms driving notch disorders and therapeutic implications
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-02-21)Biliary tree is an intricate tubular structure lined by cholangiocytes or biliary epithelial cells. The differentiation, development and morphogenesis of bile ducts is controlled by Notch signaling and other pathways. ... -
Gestational weight gain, bariatric surgery, and adverse maternal and infant outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-20)Gestational weight gain is a crucial predictor for various adverse maternal and infant outcomes. In 2009, the U.S. Institute of Medicine (IOM) introduced optimal ranges for gestational weight gain based on a woman's ... -
Prognostication in heart failure across the ejection fraction spectrum : implications for clinical practice and trial design
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-19)Background. The heterogeneity of heart failure (HF) across the ejection fraction (EF) spectrum presents a challenge when triaging for follow-up, implementing therapies, and designing trials. There is a preconceived notion ... -
Development of novel and accessible treatments for trichotillomania and skin-picking disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-15)Background: Trichotillomania (TTM) and Skin-picking disorder (SPD) are psychiatric conditions characterized by recurrent and excessive hair-pulling and skin-picking, respectively. These behaviors result in significant hair ... -
Defining human adaptive immune gene diversity
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-02-15)The lymphocytes (B and T cells) of the adaptive immune system undergo variable (V), diversity (D), and junctional (J) gene recombination, resulting in highly diverse antigen receptor repertoires capable of recognizing a ... -
Reproductive and lifestyle risk factors for sarcoidosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-14)Sarcoidosis is a systemic inflammatory condition with an unknown origin, characterized by the formation of granulomatous lesions primarily in the lungs and lymphatic system. Despite over a century since it was first ... -
The cellular thermal shift assay (CETSA) for elucidating drug mechanism of action and resistance in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-14)A complete understanding over drug mechanism of action (MoA) is important when attempting to predict treatment outcome or the presence of resistance in patients. Despite decades of scientific efforts, the MoAs of even some ... -
Determinants of age-related brain iron accumulation and links to neurocognitive functions
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-02-14)Iron is crucial for development and normal functioning of the brain. With increasing age, it accumulates in the cells and can cause irreparable damage, affecting both the structure and function of the brain. Despite these ...