Now showing items 1-20 of 8959

    • MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells 

      Karsten, Stella; Fiskesund, Roland; Zhang, Xing-Mei; Marttila, Petra; Sanjiv, Kumar; Pham, Therese; Rasti, Azita; Bräutigam, Lars; Almlöf, Ingrid; Marcusson-Ståhl, Maritha; Sandman, Carolina; Platzack, Björn; Harris, Robert A.; Kalderén, Christina; Cederbrant, Karin; Helleday, Thomas; Warpman Berglund, Ulrika (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)
      T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ...
    • Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors 

      Zhou, Chikai (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-09-14)
      The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, ...
    • Genetic predisposition to immune cell malfunction and inflammation 

      Torralba-Raga, Lamberto J. (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
      Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds ...
    • Gene regulation of acute insulin response in human adipose tissue in obesity and after weight-loss 

      Mileti, Enrichetta (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-09-10)
      The incidence and prevalence of obesity and type 2 diabetes is reaching epidemic proportions worldwide and insulin resistance, the pathophysiological link between the two conditions is consequently the focus of intense ...
    • The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination 

      Widgren, Katarina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
      Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ...
    • Long-term follow-up after risk-reducing mastectomy and immediate breast reconstruction : from a patient, partner, and 3D perspective 

      Bai, Lucy (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-10)
      BACKGROUND: Breast cancer is the most common type of cancer among women. Approximately 5–10% of all breast cancer cases have an inherited pattern, and ~20% of all hereditary cases have an identifiable mutation. Through ...
    • Learning from primary immunodeficiencies to treat cancer 

      Oliveira, Mariana M. S. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-09)
      The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ...
    • From in-situ simulation to beyond : improving paediatric trauma care 

      MacKinnon, Ralph James (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-09-08)
      Background: In-situ-simulation (ISS) has been adopted across the globe as an educational tool to enhance the quality of care provided to severely injured children. As an intervention that trains individuals where they ...
    • Cholestasis in infants at risk 

      Teng, Jonas (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-09-03)
      Cholestasis is a condition when bile flow from the liver to the intestines is impaired. Unresolved, it may lead to liver transplantation or death. Overall, it affects 1 out of 2500 term infants, but is far more common ...
    • Redox regulation of T cells in autoimmunity 

      James, Jaime Rose (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-09-03)
      Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the ...
    • Hfq- and sRNA-mediated regulation in Neisseria meningitidis 

      Karlsson, Jens (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-03)
      Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal ...
    • Population-based analyses of incidence, prognostic determinants and outcome of aortic dissection 

      Smedberg, Christian (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-09-02)
      Background: Aortic dissection (AD) is a potentially life-threatening disease caused by a tear in the innermost layer of the aortic wall, the intima, resulting in blood flow between the layers of the aortic vessel wall. ...
    • Subtypes of ischemic stroke : analysis of revascularization therapy, stroke etiology, and the role of blood pressure 

      Matusevičius, Marius (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-01)
      Background: Treatment with intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) improve outcomes for patients with acute ischemic stroke. The efficacy and safety of IVT and EVT may differ based on specific ...
    • Silica particle-induced NLRP3 inflammasome activation and DNA damage in respiratory epithelium 

      Wu, Rongrong (Institutet för miljömedicin / Institute of Environmental Medicine, 2021-08-27)
      Respirable crystalline silica particles (CSi) can persist and induce inflammation and DNA damage in human lungs. Previous studies have used complex model systems to characterize CSi-induced DNA damage, involving co-cultures ...
    • A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1) in cancer 

      Song, Dandan (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-08-24)
      Activator protein-1 (AP-1) is a transcriptional factor complex that mainly consists of Fos and Jun family members. Jun proteins can form both homodimers and heterodimers, whereas Fos family members only form heterodimers ...
    • Recovery and prediction of hand motor function after stroke : a longitudinal study using novel methods to quantify hand function and connectivity in brain networks 

      Plantin, Jeanette (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-08-24)
      Background: Stroke is a heterogeneous disease and a leading cause of physical disability among adults, severely affecting people’s health and life worldwide. According to current figures, one in four people risk suffering ...
    • Social integration and immigrant mental health : the role of social capital and neighbourhood ethnic composition 

      Johnson-Singh, Charisse (Inst för global folkhälsa / Dept of Global Public Health, 2021-08-20)
      Background: Nearly 20% of Sweden’s population are immigrants and research has identified inequalities in mental health between certain immigrant groups and the native Swedish population. The role of social integration ...
    • Improved surgical treatment of oesophageal cancer 

      Gottlieb-Vedi, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-08-20)
      Oesophageal cancer is the 7thmost common cancer globally and the 5-year survival is poor (below 20%). Curative treatment usually involves surgical resection of the tumour (oesophagectomy), with or without neoadjuvant ...
    • Autophagy and VPS34 as targets in anti-cancer therapy 

      Yu, Yasmin Désirée (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-08-20)
      Autophagy (Greek for self-eating) is a cellular pathway that breaks down cytoplasmic components to fuel metabolism. In this way, autophagy maintains cellular homeostasis and sustains survival during stress conditions. In ...
    • Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL 

      Oliveira, Daniel V. (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-08-20)
      The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the ...