Doktorsavhandlingar / Doctoral Theses: Recent submissions

Now showing items 61-80 of 9291

    • Pediatric eosinophilic esophagitis 

      Thulin, Helena (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-19)
      Background and aims: Eosinophilic Esophagitis (EoE) is an immune-mediated antigentriggered inflammatory disease, strictly located to the esophagus. The pathogenesis is still partly unknown, and there is a lack of biomarkers ...

    • Family planning service – addressing potential barriers 

      Podolskyi, Volodymyr (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)
      Background: Access to family planning service is crucial for reproductive health. Family planning service include contraceptive methods as well as safe methods for pregnancy termination when needed. It was estimated in ...

    • Genetic and epigenetic risk factors for asthma in infancy and childhood 

      Hoyer, Angela (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)
      Asthma is among the most common non-communicable diseases, with an increasing prevalence worldwide. The pathophysiology behind the disease is heterogeneous, including risk factors like genes, sex, allergies, virus infections, ...

    • Diabetes, cardiovascular events, and lifestyle : from epidemiology to clinic 

      Hummel, Madeleine (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-15)
      Today, the health care system plays an important role in the prevention of diseases, not least through support of a healthy lifestyle, including being physically active. Given the development of digital tools together with ...

    • Translational studies of glucocerebrosidase in Parkinson´s disease 

      Kojima, Rika (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-14)
      A number of genetic variants have been linked to Parkinson’s disease (PD). Among these, mutations in the GBA1 gene are identified as one of the most common risk factors for developing PD. The connection between increased ...

    • Benefit-harm assessment in childbirth care, with breech presentation as an illustration 

      Savchenko, Julia (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-11)
      Introduction: Childbirth care is aiming at safe births and positive birth experience. Obstetric decision-making is often complicated. Breech presentation is an example of such complexity. Judgements about individual cases ...

    • Exploring statistical models for estimating remaining life years & loss in life expectancy for cancer patients 

      Leontyeva, Yuliya (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-03-08)
      As advancements in cancer prognosis and treatment continue for many cancer types, there is a growing interest in estimating survival over longer time periods. The assessment of the years remaining after a cancer diagnosis, ...

    • The role of thyroid hormone function and prokineticin-1 in pregnancy and offspring outcome in women with polycystic ovary syndrome 

      Trouva, Anastasia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-06)
      Thyroid disorders are common in women with polycystic ovary syndrome (PCOS) and both conditions are associated with adverse pregnancy outcomes, such as intrauterine growth restriction, preterm delivery, and gestational ...

    • The role of pairing beyond the seed in microRNA targeting 

      Kosek, David (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-03-01)
      MicroRNAs (miRNAs) are short non-coding RNAs which act as post-transcriptional regulators of gene expression. MiRNAs complex with Argonaute proteins to form an RNA-guided silencing complex (RISC). The guide RNA recognizes ...

    • Exploring the gut microbiome in ADHD and schizophrenia spectrum disorder 

      Stiernborg, Miranda (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)
      Emerging research indicates a complex relationship between the gut bacterial microbiome and psychiatric disorders, though findings are not always consistent. The gut-brain axis, involving gut microbiota, plays a crucial ...

    • Cardiovascular magnetic resonance imaging of myocardium and pulmonary arterial pressure 

      Abdula, Goran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)
      Heart failure (HF) is a clinical syndrome characterized by high morbidity and mortality. HF can be associated with alteration in myocardial tissue composition such as focal myocardial fibrosis, also referred to as scarring, ...

    • Pathogenesis of IgA nephropathy and diabetic kidney disease : linking molecular profile to morphological and clinical picture 

      Levin, Anna (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-02-26)
      Background: More than 10% of the global population suffers from chronic kidney disease (CKD), which poses a large impact on society and, more importantly, the life of the affected patient. Two of the most common causes of ...

    • Severe poisonings in Sweden : demography, intensive care, and death 

      Lindqvist, Elin (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)
      Background: Poisonings are common and diverse in their origins, clinical presentations, and outcomes. Poisoning accounts for a substantial number of hospital admissions with need for a higher level of care. The hospital ...

    • Radiation-induced toxicity and secondary malignant neoplasms in radiotherapy of intrathoracic tumors 

      Lideståhl, Anders (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-23)
      Radiation oncology is essential in the treatment of cancer, with approximately fifty percent of oncology patients undergoing radiotherapy (RT) at some stage of their disease management. Significant progress is being made ...

    • Hemodynamic optimization in critically ill patients 

      Wall, Olof (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)
      Background: Intravenous fluids are one of the most common treatments in the health care setting and are usually given in response to hemodynamic instability or shock. However, this rests on the assumption that the cause ...

    • Engineering cell communication from nanoscale to tissue levels towards therapeutic applications 

      Kolonelou, Christina (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-02-22)
      Cell communication which is vital for the proper function, development, and survival of multicellular organisms is often disrupted in diseases. This thesis aims to enhance our understanding of cell communication by employing ...

    • Novel ophthalmological assessments for detection of optic pathway gliomas in children 

      Arnljots, Urszula (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-22)
      Optic pathway gliomas (OPGs) are vision-threatening brain lesions that are extremely important to detect at young age for appropriate medical intervention. Children with neurofibromatosis type 1 (NF1) are particularly at ...

    • Imaging the spatial organization of healthy human brain and glioblastoma 

      Mossi Albiach, Alejandro (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)
      Multicellular biological systems have a single genetic plan that contains the set of instructions to shape the three-dimensional architecture of specialized tissues and organs. The genetic plan is contained in the DNA, and ...

    • Regulation of mtDNA gene expression and the role of respiratory chain supercomplexes in mammalian mitochondria 

      Misic, Jelena (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)
      Mitochondria are cellular organelles found in nearly all eukaryotic cells, where they fulfill a plethora of functions, including energy conversion. They harness energy from carbon sources to synthesize adenosine triphosphate ...

    • Mechanisms driving notch disorders and therapeutic implications 

      Iqbal, Afshan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-02-21)
      Biliary tree is an intricate tubular structure lined by cholangiocytes or biliary epithelial cells. The differentiation, development and morphogenesis of bile ducts is controlled by Notch signaling and other pathways. ...