Doktorsavhandlingar / Doctoral Theses: Recent submissions
Now showing items 1-20 of 9355
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Angiogenesis in ocular neovascular diseases : from multitarget inhibition to gene therapy tools
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-16)Ocular neovascular diseases, such as neovascular age-related macular degeneration (nAMD) or proliferative retinopathies (PRs) are characterized by the growth of abnormal blood vessels in the eye, leading to vision impairment. ... -
Unravelling host-bacterial interactions using tissue microbiology approaches
(Inst för neurovetenskap / Dept of Neuroscience, 2024-08-16)To fully grasp the complexity of host-pathogen interactions, there is a pressing need for more advanced and comprehensive infection models. Infections can occur at various sites within the body, each with its own unique ... -
Post-migration and stigma-based factors influencing mental health among refugees and sexual minority migrants
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-08-16)This thesis investigated how experiences in the new country of residence influence mental health among two subgroups among migrants that have been shown to be at heightened risk of developing poor mental health: refugees ... -
Dynamics of transcriptomic and epigenomic states in mouse and human central nervous system cells in multiple sclerosis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-08-12)Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by immunologically mediated demyelination in the central nervous system (CNS). Oligodendrocytes, a type of glial cell in the CNS, are responsible for ... -
Mechanisms controlling the latent HIV-1 provirus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-08-09)HIV is incurable due the persistence of latent but replication competent HIV proviruses. Lifelong antiretroviral therapy (ART) stops HIV progression to AIDS with minimal side effects. However, a HIV cure has only been ... -
Bridging time and space in the brain : 14C dating and spatial transcriptomic analysis give new insight into neurological disease
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-08-09)Conditions affecting the nervous system are collectively the largest contributor to ill health and disability worldwide, and the therapeutic options for many neurological diseases remain limited. For a long time, it was ... -
Responses to cellular stress in malaria parasites
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-08-09)Malaria remains a global health burden with almost half of the world’s population being at risk of infection. While the disease can be caused by several Plasmodium species, this thesis focuses on the most virulent species ... -
Role of non-cardiac comorbidities in heart failure across the ejection fraction spectrum : diagnosis, treatment and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-08-09)Background. Heart failure (HF) represents a significant challenge due to its heterogeneous nature across the spectrum of ejection fraction (EF). This heterogeneity is in part characterized by a difference in distribution ... -
Persistent crisis in healthcare : psychological stress reactions and psychological support for healthcare workers during the COVID-19 pandemic
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-08-09)Background: Even before the COVID-19 pandemic, healthcare workers were affected by high job demands and had an increased risk of developing psychological stress symptoms. During the COVID-19 pandemic, the prevalence of ... -
Understanding cochlear development : insights from a notch disease model and lineage tracing of In utero barcoded otic progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-08-09)The organ of Corti, located in the cochlea of the inner ear, is the organ for auditory perception in mammals. Proper auditory function depends on the formation of a precise mosaic of mechanosensory inner hair cells (IHCs), ... -
Prevention of cognitive decline after radiation therapy
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-08-07)Central nervous system tumours are the leading cause of cancer-related deaths in children and the second-most-common malignancy diagnosed after leukaemia. Advances in treatment regimens and multimodal strategies, from ... -
Multiomic analysis of T cells in response to cancers and microbes
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-08-05)The human immune system consists of various cell subsets, cytokines and their interactions. Traditionally researchers focus on one compartment at a time, however, with the advance in high-throughput, multi-omics techniques, ... -
Deciphering oligodendrocyte lineage heterogeneity in development and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-07-30)Oligodendrocytes are the myelinating glia of the central nervous system (CNS). By forming lipid-rich myelin membranes that spirally enwrap axonal segments, oligodendrocytes ensure rapid saltatory impulse propagation, ... -
A clear picture of the perivascular cell landscape and its implication in tissue functions
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-07-30)The vasculature of every organ is adapted to the specific tissue functions with activity-dependent blood flow control. While the lumen of blood vessels is formed by endothelial cells (ECs), their abluminal surface is covered ... -
Clinical and experimental implementation of standardized hypothermic treatment for neonatal asphyxia in low-income settings
(Inst för global folkhälsa / Dept of Global Public Health, 2024-07-30)Background: Hypoxic ischemic encephalopathy (HIE) is a potentially devastating condition caused by birth asphyxia. The standard of care for infants with moderate and severe HIE is therapeutic hypothermia (TH), initiated ... -
Perspectives on metal-on-metal hip resurfacing
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-07-05)The overall aim of this thesis was to study patients with metal-on-metal hip resurfacing (MoM-HR). More specifically, we investigated if there are any advantages in patient-reported outcome measures (PROM) after MoM-HR ... -
Fast multi-contrast magnetic resonance imaging of the brain : a diagnostic performance study
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-07-03)Background: Fast MRI is beneficial in time-critical situations like ischemic stroke and motion-prone patients and to meet the increasing clinical demand. Two fast and motion-robust, single-scan multi-contrast MRI techniques, ... -
A biophysical symphony : the interplay of factors determining microRNA-34a activity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-28)microRNAs (miRNAs) play a pivotal role as post-transcriptional regulators in gene expression, adding a layer of complexity to the intricate system of molecular interactions within cells. Despite their short length, miRNAs ... -
Stress in military settings
(Inst för neurovetenskap / Dept of Neuroscience, 2024-05-28)Stress in the military reality is often related to either mental health or performance. When it comes to mental health, most of the literature is concerned with the possible negative effects from exposure to combat-related ... -
Novel biomarkers associated with stress : from normal aging to Alzheimer's disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-27)The burden of Alzheimer’s disease (AD) and dementia can be reduced through the elimination of modifiable lifestyle risk factors. Chronic stress is an emerging risk factor which has received significant focus in research ...