Now showing items 1-20 of 7350

  • Multimodality treatment of oesophageal cancer : effects and side effects 

    Alexandersson von Döbeln, Gabriella (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-10-22)
    Background: Oesophageal cancer is highly fatal and treatment with curative intent is beset with many side effects. Treatment options are (1) chemoradiotherapy, (2) chemotherapy with or without the addition of radiotherapy ...
  • Innovation inside the box : how contextual constraints can contribute to improvement in health care 

    Storkholm, Marie Højriis (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-10-19)
    Background Health care is becoming increasingly complex because of the major advances achieved in clinical and biomedical knowledge in the last 50 years. Many more important advances are on the horizon that will create ...
  • Cervical intraepithelial neoplasia in migrant women living with HIV 

    Carlander, Christina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-19)
    The aim of this thesis was to study high-grade cervical intraepithelial neoplasia (CIN) in women living with HIV (WLWH) in Sweden compared with HIV-negative women (HNW) of the same region of birth. In Paper I ...
  • Effects of a structured lifestyle program for individuals with high cardiovascular risk 

    Lidin, Matthias (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-19)
    Cardiovascular disease (CVD) is the leading cause of death in Sweden as well as in the rest of the world. CVD is mainly caused by unhealthy lifestyle habits and lifestyle-related risk factors. National and international ...
  • Immune response and tumour cell detection in lymph nodes of head and neck cancer 

    Kågedal, Åsa (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-18)
    Many patients with head and neck squamous cell carcinoma present with regional spread to the cervical lymph nodes. Lymph nodes metastases are today the most important factor influencing both the treatment and outcome for ...
  • Novel insights into dishevelled and frizzled function 

    Valnohova, Jana (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-18)
    The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling ...
  • Innate immune factors in recurrent and persistent infections of the lower female genital tract 

    Alvendal, Cathrin (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-18)
    Background: Infections of the female genital tract are common and have severe impact on the quality of life and sexual health of affected women. The innate immune system is crucial and is involved in the defense of infections. ...
  • Role of GPS2 in epigenome alterations linked to metaflammation 

    Huang, Zhiqiang (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ...
  • Locus specific DNA methylation in human immunological responses 

    Ahlén Bergman, Emma (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-18)
    All cells in the human body contains the same genome. Yet, there are hundreds of different cell types, with widely different phenotype, and function. The differential gene expression leading to this diversity is tightly ...
  • Objective quantification and analysis of eating behaviour associated with obesity development - from lab to real-life 

    Langlet, Billy (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Introduction: The last four decades have seen a marked increase in childhood and adult obesity prevalence, attributed to an “obesogenic” environment. Several genetical, environmental and behavioural factors have been ...
  • Survivorship in Hodgkin lymphoma : childbearing and treatment-related disease 

    Weibull, Caroline E. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-10-16)
    Cancer is often considered a disease with, historically, poor survival that affects middle-aged and elderly individuals. Hodgkin lymphoma (HL) is a lymphatic malignancy that affects both young and old individuals, with the ...
  • Extracorporeal membrane oxygenation (ECMO) for the treatment of cardiogenic shock : identification of pre-implant outcome predictors 

    Fux, Thomas (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    Background: Refractory cardiogenic shock (RCS), cardiac arrest (CA) and postarrest cardiogenic shock (CS) are associated with high mortality. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used ...
  • In vitro models aiming for fertility preservation 

    Albalushi, Halima (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-10-11)
    Fertility preservation is considered a great hope to people suffering from infertility as a consequence of developmental or genetic cause, a disease itself or its treatments sequelae. In vitro models are fundamental to ...
  • Multidisciplinary analysis of HIV-1 elite controllers 

    Noyan Gertler, Kajsa (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-10-11)
    Chronic HIV-1 infection is characterized by progressive depletion of CD4+ T lymphocytes, persistent immune activation and ongoing viral replication, leading to a profound immunodeficiency state if left untreated with ...
  • Environmental regulation of metabolism : from transgenerational effects of nutrition to acute effects of exercise 

    Alm, Petter (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-10-08)
    The incidence of metabolic disease has risen rapidly in the last half-century leading to both individual suffering and a burden to society. The importance of physical activity for metabolic health is well known. Furthermore, ...
  • Sex and gender differences in patients undergoing ablation of atrial arrhythmias 

    Carnlöf, Carina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-08)
    Background: Women and men differ in the prevalence of arrhythmias. Furthermore, there are sex and gender differences in referral for ablation, symptom severity, health-related quality of life (HRQOL), functional impairment ...
  • The experience of being new and desirable support during the first year in the emergency medical services 

    Hörberg, Anna (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-10-05)
    The emergency medical services (EMS) has been described as a challenging professional practice where the persons in need of care vary greatly in terms of age, symptoms and situations. There is limited research regarding ...
  • Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers 

    Leuzy, Antoine (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-10-05)
    Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in ...
  • Adaptive immunity in urothelial cancer : molecular and clinical aspects 

    Krantz, David (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-05)
    In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ...
  • Growth hormones in chronic kidney disease 

    Nilsson, Erik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-05)
    Several hormonal systems are disrupted in chronic kidney disease (CKD) and disturbances of the growth hormone axis could contribute to increased morbidity and mortality through effects on cardiovascular health, energy ...