Doktorsavhandlingar / Doctoral Theses: Recent submissions
Now showing items 1-20 of 9268
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From autoimmunity to inflamed joints : study of risk factors, mediators and cellular targets in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-24)Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting mainly the joints and leading to disability. Circulating antibodies against citrullinated proteins (ACPA) are present in the majority of patients and ... -
Impact of childhood leukemia and its treatment on Nordic children and families : the consent process, toxicity, and quality of life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-24)Background: The survival rate in acute lymphoblastic leukemia (ALL) has improved remarkably over the last half-century and is now reaching above 90%. The treatment is lengthy, however, and with a high risk of short- and ... -
Scare or care? How immunological processes shape perception of sickness-relevant stimuli in humans
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-23)Humans and other animals have developed several defense systems to handle living in a pathogen-rich world. These defense systems include immune responses, as well as behavioral responses aimed at supporting immune ... -
Primary cilia in human neuron differentiation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-04-23)Primary (non-motile) cilia have long been overlooked, considered vestigial organelles lacking specific functions. In humans, all cell types except sperm, ependymal and bronchial epithelial cells, and oviduct cells ... -
Risk factors for colorectal cancer and the impact on life in lynch syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-23)Colorectal cancer (CRC) constitutes the third most common cancer in Sweden. Approximately 2-4% of CRC cases have a pathogenic variant in a gene known to cause an inherited risk of CRC. The most common hereditary CRC ... -
Developing an embryonic stem cell-based cell product for age-related macular degeneration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-22)Age-related macular degeneration (AMD) remains a major cause of blindness with no current cure. With the increasing ageing population in the developed world, a high number of AMD patients is expected. AMD can be distinguished ... -
Exploring T cell mediated immunotherapy against therapy resistant leukemic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-19)The cancer stem cell (CSC) model suggests that cancers depend on continuous replenishment from rare and distinct CSCs, but their existence has been challenging to prove for many malignancies. The CSCs in myeloid ... -
Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ... -
Infections, antibiotics, tobacco, genetic factors and risk of lada : latent autoimmune diabetes in adults, and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-17)Diabetes is a spectrum of chronic diseases characterized by hyperglycaemia. The aetiology and pathogenesis differ between types of diabetes, but all can lead to severe complications. Latent autoimmune diabetes in adults ... -
Immediate skin-to-skin contact after a very preterm birth : supporting the parent-infant relationship
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-16)Background: Preterm birth poses challenges that may negatively affect parental mental health and infant development. A well-functioning parent-infant relationship can mitigate the risk of preterm birth on infant development, ... -
Novel diagnostic and prognostic tools in infiltrative cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-16)Background: Heart failure is a severe medical condition, increasingly common in the aging population, causing both vast morbidity and mortality. Amongst different etiologies of heart failure, infiltrative cardiomyopathies ... -
Understanding the roles of avidity in biological systems
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-04-11)Understanding avidity is essential for elucidating complex molecular interactions and designing effective therapeutic strategies. This thesis aims to explore strategies and tools to understand how avidity influences ... -
Cancer risk, autoimmune comorbidity and autoantibodies in primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-05)Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease affecting the bile ducts primarily, and the liver parenchyma secondarily. The disease is progressive but highly variable between diseased. Some ... -
Sexual and reproductive health and rights among newly arrived migrants in Sweden : knowledge gaps and healthcare challenges
(Inst för global folkhälsa / Dept of Global Public Health, 2024-04-04)Introduction: Migration is one of today’s most pressing issues, especially concerning sexual and reproductive health and rights (SRHR) and human rights. Migrants may face heightened health vulnerabilities due to challenges ... -
Lineage, cell state and cell identity in the developing human brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-04)Organisms are complex systems consisting of thousands of distinct types of cells that perform a wide array of functions, yet for the most part share the same DNA. To regulate the expression of genes, the genome contains a ... -
From vaccination to infection : mechanistic studies of immune responses to SARS-CoV-2
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-04)The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 elevated population-level immunity and reduced ... -
In search of therapeutic candidates for tandem repeat disorders
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-04)Triplet-repeat disorders, including Friedreich's Ataxia (FRDA) and Huntington's disease (HD), are genetic conditions characterized by the expansion of specific trinucleotide sequences within affected genes. In FRDA, the ... -
Physiological and lifestyle-related cardiovascular risk factors for vessels, ventricle, and valve
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-03)Cardiovascular diseases are the most common cause of mortality globally, claiming twice as many lives as cancer and more than all nutritional disorders, infectious diseases, and maternal/neonatal conditions combined. The ... -
Genetic studies of rare skeletal disorders : to solve the unsolved
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-03)Congenital skeletal disorders, also called skeletal dysplasias, constitute a diverse group of rare genetic conditions that occur in approximately 1 per 3000-5000 births. Skeletal dysplasias exhibit both clinical and molecular ...