Now showing items 1-20 of 7083

  • B cell subsets in autoimmune disease 

    Habir, Katrin (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-01-12)
    B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system and involved in creating immunological memory. B cells function in the humoral immune system by secreting antibodies which ...
  • Losing connections in Alzheimer Disease : the amyloid precursor protein processing machinery at the synapse 

    Lundgren, Jolanta L. (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-01-11)
    Synaptic degeneration is one of the earliest characteristics of Alzheimer disease (AD). The amyloid β-peptide (Aβ) plays a critical role in the pathology of AD and therefore thorough understanding of its production and ...
  • Survival and renal function after acute kidney injury : epidemiological and biomarker studies 

    Rimes-Stigare, Claire (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-01-10)
    Acute Kidney Injury (AKI) occurs frequently in the critically ill and has an extremely high short-term mortality. The long-term risks of death, Chronic Kidney Disease (CKD) and End Stage Renal Disease (ESRD) have not been ...
  • Colon cancer : aspects on surgical treatment and complete mesocolic excision 

    Bernhoff, Richard (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-09)
    In rectal cancer, total mesorectal excision (TME), including surgery with dissection outside the mesorectal fascia, together with pre-operative radiotherapy improves survival. An educational effort on TME improved results ...
  • Effects on tumor immunity, liver, gut, lung and survival after cutaneous graft-versus-host disease regulated by photochemotherapy 

    Feldreich, Nicolas (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-01-09)
    The present thesis describes the effect and timing of photochemotherapy in relation to the onset and severity of cutaneous graft-versus-host (GvHD) in relation to the survival and cure of patients. Leukemia is the most ...
  • Postmenopausal hormone therapy and cardiovascular risk 

    Carrasquilla, Germán D. (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-01-09)
    Introduction and aims: Postmenopausal hormone therapy (HT) is the most effective treatment for menopausal symptoms, but its safety has been debated during the past 15 years. Previous observational studies showed benefits ...
  • Experimental and computational analysis of human GM-CSF producing Thelper cells 

    Éliás, Szabolcs (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-01-04)
    Thelper cells are crucial elements of the immune system, and they differentiate into several subsets depending on their cytokine environment. Each subset contributes to a certain type of immune response by producing its ...
  • MicroRNAs and their processing factors in Caenorhabditis elegans and human cancers 

    Chang, Roger (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-01-04)
    MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-22 nucleotides (nt) long. These small RNAs (sRNAs) was initially discovered in Caenorhabditis elegans (C. elegans), but is conserved in over 50 animal species. ...
  • Studies of amyloid precursor protein trafficking and processing 

    Xu, Shaohua (Inst för neurovetenskap / Dept of Neuroscience, 2018-01-04)
    Alzheimer’s disease (AD) is the most common form of neurodegenerative disease that slowly impairs memory and thinking abilities. Abnormal accumulation and aggregation of amyloid β peptides (Aβ), derived from proteolytic ...
  • Better balance with somatosensory exercises : a Parkinson perspective 

    Claesson, Ingrid (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-01-04)
    BACKGROUND: People with Parkinson’s Disease (PD) experience increasing activity limitations in walking, carrying objects, turning around, and dressing. Subtle and often unconscious balance decline may have occurred already ...
  • Dual dispatch and the importance of bystander CPR in out-of-hospital cardiac arrest 

    Hasselqvist-Ax, Ingela (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-12-29)
    Background and aim Survival after out-of-hospital cardiac arrest (OHCA) remains low. In Sweden in 2016, of 5312 cases reported to the Swedish Register of Cardiopulmonary Resuscitation (SRCR), only 577 (11%) survived ...
  • Molecular and clinical sexual dimorphism in systemic autoimmunity 

    Ramírez Sepúlveda, Jorge Iván (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-12-22)
    Biological differences between the sexes of a species, also known as sexual dimorphism, can be found throughout developmental, physiological and pathological processes. In human disease, sexual dimorphism can explain marked ...
  • Tumor microenvironment : the paradoxical action of fibroblasts 

    Alkasalias, Twana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-22)
    The term tumor refers to an abnormal and pathological tissue characterized by a massive cell growth; it comprises various populations of transformed and malignant cells. These cells cross-communicate with each other and ...
  • Receptor localization and dynamics of murine natural killer cells at single cell level : using advanced fluorescence microscopy 

    Bagawath Singh, Sunitha (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-21)
    Natural Killer (NK) cells are immune cells and important for the defense against virally infected and malignant cells. NK cells are regulated by germline encoded activating and inhibitory receptors. Activating receptors ...
  • Endothelial - mural cell interplay in regulation of blood- and lymph vessel development and function 

    Wang, Yixin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-21)
    Blood- and lymphatic vascular development and homeostasis depend on correct endothelial- mural cell interaction, and dysregulation thereof is apparent in multiple human diseases. However the mechanisms controlling the ...
  • Phagocytic cells and Streptococcus pyogenes in invasive infections : an inflammatory relationship 

    Snäll, Johanna (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-12-21)
    Severe Streptococcus pyogenes infections, such as streptococcal toxic shock syndrome and necrotizing soft tissue infections, are rare but life threatening conditions. They are characterized by high bacterial load and a ...
  • Patients with femoral and tibial shaft fractures : aspects on epidemiology and pain therapy 

    Al Dabbagh, Zewar (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-12-21)
    Background: Fractures of the tibial and femoral shafts are common injuries with outcomes depending on injury mechanism, fracture pattern, patient-specific data and treatment methods. Nationwide epidemiological data on these ...
  • Hyperthyroidism and its impact on cardiovascular disease : with special emphasis on atrial fibrillation 

    Giesecke, Peter (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-21)
    Background Hyperthyroidism is a common disease throughout the world, affecting 0.5%-2% of women and one-tenth as many men at some time. Graves’ disease and toxic nodular goitre are the two most common etiologies. ...
  • Do psychosocial working conditions contribute to healthy and active aging? : studies of mortality, late-life health, and leisure 

    Nilsen, Charlotta (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-12-20)
    The growing demographic challenge posed by an aging population makes finding predictors of health in old age increasingly important. This thesis investigated long-term associations between midlife psychosocial working ...
  • Genes and brain tumors 

    Adel Fahmideh, Maral (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-12-19)
    Although brain tumors are rare and combined with other nervous system tumors account for ~ 2% of all cancers, they are the second most common type of pediatric cancer. The etiology of brain tumors, known as multifactorial ...